Cell Metabolism News and Research

RSS

AMPK suppression and SREBP activation are root cause of fatty liver and hyperlipidemia in type 2 diabetes

Researchers from Boston University School of Medicine, including Yu Li, PhD, and other colleagues, have demonstrated that a nutrient sensing pathway is involved in the disruption of cellular lipid homeostasis in obese and insulin resistant mice fed a diet high in fat and sucrose.

6 Apr 2011

Huntingtin protein is responsible for metabolic imbalances in hypothalamus

In Huntington's disease, the mutant protein known as huntingtin leads to the degeneration of a part of the brain known as the basal ganglia, causing the motor disturbances that represent one of the most defining features of the fatal disease.

6 Apr 2011

Scientists uncover SREBP-2 role in autophagy and cholesterol generation

Not all cholesterol is bad. Every cell requires it for growth - they either have to get cholesterol somewhere or they die. In a new study published April 6 in the journal Cell Metabolism, researchers from Sanford-Burnham Medical Research Institute and their collaborators found that a protein sensor known to balance cholesterol sources can also access a previously underappreciated cellular fat storage depot.

6 Apr 2011

Intravenous Phenoxodiol-cisplatin combination well tolerated in platinum resistant ovarian cancer

Marshall Edwards, Inc., an oncology company focused on the clinical development of novel therapeutics targeting cancer metabolism, announced today the publication of results from a Phase II clinical trial of intravenous Phenoxodiol in combination with cisplatin in women with platinum-resistant ovarian cancer.

21 Mar 2011

FibroGen, Astellas advance FG-4592 to phase 2b development for treatment of anemia in chronic kidney disease

FibroGen, Inc., today announced that FibroGen and partner Astellas Pharma Inc. advanced FG-4592 (Astellas designation ASP1517), an investigational anemia therapy, to phase 2b development for treatment of anemia in chronic kidney disease (CKD) patients on dialysis and not on dialysis.

18 Mar 2011

Researchers discover molecular switch for insulin secretion

16 Mar 2011

Discovery of molecular switch for the secretion of insulin

Johns Hopkins researchers believe they have uncovered the molecular switch for the secretion of insulin — the hormone that regulates blood sugar — providing for the first time an explanation of this process. In a report published online March 1 in Cell Metabolism, the researchers say the work solves a longtime mystery and may lead to better treatments for type 2 diabetes, the most common form of the disease.

15 Mar 2011

Positive results from azide drug-loaded Emulsiphan preclinical toxicity study

Cornerstone Pharmaceuticals, Inc., a leader in cancer metabolism-based therapeutics, today announced encouraging results of a preclinical toxicity study of azide drug-loaded Emulsiphan nano emulsions conducted with the National Cancer Institute (NCI) under a Collaboration Agreement. Emulsiphan is Cornerstone's proprietary nanoparticle drug delivery system.

14 Mar 2011

Researchers demonstrate potential neurochemical mechanism of weight loss

An interdisciplinary group of researchers at the University of Pennsylvania has, for the first time, identified the neurological and cellular signaling mechanisms that contribute to satiety - the sensation of feeling full - and the subsequent body-weight loss produced by drugs used to treat type 2 diabetes. More comprehensive knowledge of these mechanisms could form the basis for anti-obesity medications.

4 Mar 2011

New discovery in glioma-associated metabolic changes

Metabolon, Inc., the leader in metabolomics, biomarker discovery and analysis, announces the publication of "Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome", in The Proceedings of the National Academy of Sciences.

3 Mar 2011

Promising new way to lower cholesterol production

A promising new way to inhibit cholesterol production in the body has been discovered, one that may yield treatments as effective as existing medications but with fewer side-effects.

3 Mar 2011

Glycogen study findings shed light on possible route to treat Lafora disease

Indiana University scientists have solved a perplexing mystery regarding one of the body's main energy storage molecules, in the process shedding light on a possible route to treatment of a rare but deadly disease in teenagers.

2 Mar 2011

Scientists discover signaling pathway in brain to induce cellular leptin resistance

Researchers at UT Southwestern Medical Center have identified a signaling pathway in the brain that's sufficient to induce cellular leptin resistance, a problem that decreases the body's ability to "hear" that it is full and should stop eating.

2 Mar 2011

Genetic switch increases blood vessels in skeletal muscle of non-exercising mice

Many people suffer from a devastating condition known as critical limb ischemia (CLI) that can lead to muscle wasting and even amputation. The disease is linked to the blockage of blood flow to the skeletal muscle and current treatment options include rehabilitative exercise and surgical bypass of blood vessels. New preclinical research suggests there may be a way to restore blood supply in skeletal muscle without traditional intervention.

2 Mar 2011

Impaired brain insulin action may worsen type 2 diabetes

Researchers from Mount Sinai School of Medicine have discovered a novel function of brain insulin, indicating that impaired brain insulin action may be the cause of the unrestrained lipolysis that initiates and worsens type 2 diabetes in humans. The research is published this month in the journal Cell Metabolism.

17 Feb 2011

Study sheds new light on riboswitch that turns genes on or off in response to cell's energy needs

Scientists from The Scripps Research Institute have shed new light on a molecular switch that turns genes on or off in response to a cell's energy needs.

13 Feb 2011

Afinitor plus BSC doubles progression-free survival in patients with advanced pancreatic neuroendocrine tumors

The New England Journal of Medicine (NEJM) published a study today that shows Afinitor® (everolimus) tablets plus best supportive care (BSC) more than doubled progression-free survival (PFS), or time without tumor growth, versus placebo plus BSC in patients with advanced pancreatic neuroendocrine tumors (NET).

10 Feb 2011

Drugs against protective action of bacteria's antitoxin molecules

Bacteria often attack with toxins designed to hijack or even kill host cells. To avoid self-destruction, bacteria have ways of protecting themselves from their own toxins.

9 Feb 2011

Super spinach really boosts power: Study

Scientists have found out the basis of what we already knew – spinach is good for us. They have found that it is the nitrates in spinach that are abundant in all green leafy vegetables that boosts the powerhouses in cells which provide energy. In fact a single helping of spinach is enough to increase the efficiency of mitochondria. These are small bean-shaped bodies which fuel cell activity and growth. This explains how Popeye the Sailor man – a famous cartoon character, who dates back to the 1930s, gets his power from a can of spinach.

6 Feb 2011

Five young scientists receive Damon Runyon-Rachleff Innovation Award for cancer research

The Damon Runyon Cancer Research Foundation announced that five scientists with novel approaches to fighting cancer have been named 2011 recipients of the Damon Runyon-Rachleff Innovation Award. The grant of $450,000 over three years is awarded each year to early career scientists whose projects have the potential to significantly impact the prevention, diagnosis and treatment of cancer.

2 Feb 2011

Cell Metabolism News and Research

AMPK suppression and SREBP activation are root cause of fatty liver and hyperlipidemia in type 2 diabetes

Huntingtin protein is responsible for metabolic imbalances in hypothalamus

Scientists uncover SREBP-2 role in autophagy and cholesterol generation

Intravenous Phenoxodiol-cisplatin combination well tolerated in platinum resistant ovarian cancer

FibroGen, Astellas advance FG-4592 to phase 2b development for treatment of anemia in chronic kidney disease

Researchers discover molecular switch for insulin secretion

Discovery of molecular switch for the secretion of insulin

Positive results from azide drug-loaded Emulsiphan preclinical toxicity study

Researchers demonstrate potential neurochemical mechanism of weight loss

New discovery in glioma-associated metabolic changes

Promising new way to lower cholesterol production

Glycogen study findings shed light on possible route to treat Lafora disease

Scientists discover signaling pathway in brain to induce cellular leptin resistance

Genetic switch increases blood vessels in skeletal muscle of non-exercising mice

Impaired brain insulin action may worsen type 2 diabetes

Study sheds new light on riboswitch that turns genes on or off in response to cell's energy needs

Afinitor plus BSC doubles progression-free survival in patients with advanced pancreatic neuroendocrine tumors

Drugs against protective action of bacteria's antitoxin molecules

Super spinach really boosts power: Study

Five young scientists receive Damon Runyon-Rachleff Innovation Award for cancer research

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News