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Targeted magnetic nanoparticles may be useful in both detecting and treating metastatic breast cancer

An in-depth study of nanoparticle distribution in tumor-bearing mice has shown that targeted magnetic nanoparticles accumulate and cluster in both primary breast tumors and metastatic lesions that have developed in the lung.

21 Aug 2006

DNA overwinds when stretched

Most of us are familiar with the winding staircase image of DNA, the repository of a biological cell's genetic information. But few of us realize just how tightly that famous double helix is wound.

8 Aug 2006

Leukemia gene changes genetic packaging

A signaling system involved in many forms of leukemia and lymphoma is more powerful than scientists have thought, exerting control over our genes by affecting whole swaths of chromosomes in global fashion.

6 Aug 2006

Actual meal time activates genes in specific brain area

Giving up your regular late-night snack may be hard, and not just because it's a routine.

6 Aug 2006

Researchers determine structure of an important smallpox virus enzyme and how it binds to DNA

Researchers at the University of Pennsylvania School of Medicine have determined the structure of an important smallpox virus enzyme and how it binds to DNA.

4 Aug 2006

Scientists characterize structure of calbindin-D28K

Scientists at North Carolina State University have effectively lifted the veil from an important protein that is linked to the prevention of neurodegenerative diseases like Alzheimer's and Huntington's.

26 Jul 2006

Heat sensitivity may make testicular cancer cells more susceptible to standard treatments and die off more readily

Experts at Johns Hopkins have linked scientific evidence spanning more than 30 years to suggest an explanation for why testicular cancer patients like seven-time Tour de France winner Lance Armstrong survive far better than patients with other advanced cancers.

26 Jul 2006

Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells

Various types of carbon-based nanomaterials, such as buckyballs and nanotubes, have shown promise as drug delivery tools and imaging agents, but reports of toxicity associated with some of these materials have raised questions about their ultimate utility in clinical oncology.

10 Jul 2006

New polymer-lipid hybrid nanoparticle

A novel combination of lipids, a negatively charged polymer, and the anticancer drug doxorubicin has yielded a new nanoparticle that can kill breast cancer cells that are normally resistant to this drug.

3 Jul 2006

Thermosensitive pluronic micelles stabilized by shell cross-linking with gold nanoparticles

Many types of nanoparticles can cross the cell membrane and deliver their therapeutic payload into tumor cells.

3 Jul 2006

Researchers discover new cell structures

New breakthrough for children suffering from an extremely rare disease that accelerates the aging process by about seven times the normal rate.

28 Jun 2006

Brain chemistry finding suggests new target for addiction treatments

Ask anyone who has been addicted to drugs and they'll tell you that the mere sight of someone using their drug of choice - or even people, places, or objects associated with drug use - can trigger an intense desire for the drug.

14 Jun 2006

Protein called Elk-1appears to play role in neurodegeneration and schizophrenia

Pprotein called Elk-1 interacts with mitochondria, the energy storehouse of a cell, suggesting that this protein - typically active in the nucleus - could play a role in cell death and mitochondria-related diseases such as neurodegeneration and schizophrenia.

9 Jun 2006

Researchers increase bone mass by tweaking the shape of a regulatory protein

Howard Hughes Medical Institute (HHMI) researchers at Stanford University have found that they can increase bone mass in mice by tweaking the shape of a regulatory protein.

6 Jun 2006

Molecular pathway may contribute to age related diseases

A common molecular denominator in aging and many age-related diseases is oxidative stress.

1 Jun 2006

Bipolar disorder causes children to misinterpret facial expressions

Researchers at the National Institute of Mental Health (NIMH) have discovered why children with bipolar disorder tend to be more aggressive and irritable and have poorer social skills than healthy children.

31 May 2006

Scientists map the entire active protein inventory in cells

Scientists have shown how cutting-edge methods can be used to catalogue the entire inventory of active proteins in cell organelles at a particular moment. Their work sheds considerable light on how cells use proteins.

29 May 2006

Body has more than one body clock

Research conducted at Oregon Health & Science University suggests that contrary to popular belief, the body has more than one "body clock."

23 May 2006

In vivo, in vitro, in silico

Prof. Jens Reich, Biomathematician and member of the German National Ethics Council, is one of the scientists within the Systems Biology competence network HepatoSys who is on the scent of a major mystery of life.

17 May 2006

Plasminogen activator inhibitor type 2 may play role in infection and dry eye

Plasminogen Activator Inhibitor Type 2 (PAI-2), a protein found in various cell types including the skin, has been discovered in the tissue covering the eye and may have future clinical implications in various pathologies of the ocular surface such as eye infection or dry eye.

17 May 2006