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New tool to help unravel the function of an elusive DNA structure

A Rensselaer researcher has developed a new tool to help unravel the function of an elusive DNA structure. The findings, which were presented today at the 230th national meeting of the American Chemical Society (ACS) in Washington, D.C., could lead to a better understanding of diseases such as cancer and diabetes.

29 Aug 2005

Neurotransmitter orexin influences reward processing - associated with pleasure and reward pathways in the brain

Researchers at the University of Pennsylvania School of Medicine have discovered that the recently identified neurotransmitter orexin (also known as hypocretin) influences reward processing by activating neurons in the lateral hypothalamus region of the brain.

28 Aug 2005

New knowledge into the molecular mechanisms involved in tumor growth

Scientists at the University of North Carolina at Chapel Hill have identified a molecular protein's critical role in cell division and growth.

26 Aug 2005

First direct evidence that endorphins play a role in the phenomenon known as the placebo effect

Just thinking that a medicine will relieve pain is enough to prompt the brain to release its own natural painkillers, and soothe painful sensations, a new University of Michigan study finds.

23 Aug 2005

New technique for creating human embryonic stem cells

Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells. The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells.

22 Aug 2005

Enzyme called matriptase, when left to its own devices, can cause cance

Scientists at the National Institute of Dental and Craniofacial Research (NIDCR) and colleagues report in animal studies that a single, scissor-like enzyme called matriptase, when left to its own devices, can cause cancer.

16 Aug 2005

Activated Stat5 protein in prostate cancer can predict outcome, may help target treatment

Researchers from Lombardi Comprehensive Cancer Center at Georgetown University found that testing for an activated Stat5 protein in prostate tumor tissue effectively predicts which men have a form of prostate cancer that may become more aggressive and life threatening.

15 Aug 2005

Pre-mRNA that codes for inflammatory protein identified

In a discovery that upends a longstanding tenet of human biology, University of Utah School of Medicine researchers have shown that a key process in gene regulation can occur in human platelets, unique cells that are unusual because they don't have a nucleus (anucleate).

11 Aug 2005

Researchers find drug targets for treating metabolic syndrome

Ongoing studies by researchers at UT Southwestern Medical Center and other institutions have uncovered the biochemical basis of many of the factors contributing to what is known as the metabolic syndrome, suggesting potential new drug targets for treating the condition.

11 Aug 2005

New laser therapy that destroys cancer cells but leaves healthy ones unharmed

Scientists at Stanford University have developed a new laser therapy that destroys cancer cells but leaves healthy ones unharmed. The new, non-invasive treatment is described in a study published in the Aug. 1 online edition of the Proceedings of the National Academy of Sciences (PNAS).

2 Aug 2005

Controlling the expression of genes by turning them on or off could produce a drug for the treatment or cure of almost any disease

A new technique aimed at directly controlling the expression of genes by turning them on or off at the DNA level could lead to drugs for the treatment or cure of many diseases, say researchers at UT Southwestern Medical Center.

1 Aug 2005

Molecular link between a viral infection and development of a common and fatal form of liver cancer

Researchers at The University of Texas M. D. Anderson Cancer Center have uncovered a crucial molecular link between a viral infection and development of a common and fatal form of liver cancer. In the process, they have identified a possible way to treat this disease as well as a number of other cancers.

26 Jul 2005

Multi-species genome comparison sheds new light on evolutionary processes

An international team that includes researchers from the National Human Genome Research Institute (NHGRI) has discovered that mammalian chromosomes have evolved by breaking at specific sites rather than randomly as long thought - and that many of the breakage hotspots are also involved in human cancer.

25 Jul 2005

Crucial molecular link between a hepatitis B virus (HBV) and hepatocellular carcinoma (HCC)

21 Jul 2005

Cocaine induces abnormal enhancement of neuronal connections

Researchers working with rats have zeroed in on the brain circuitry mechanism whose disruption contributes to the impulsive behavior seen in users of cocaine as well as other psychostimulant drugs. The same circuitry has been implicated in such disorders as schizophrenia, depression, and post-traumatic stress disorder, wrote the researchers.

21 Jul 2005

New molecular insights may one day lead to opportunities to stave off old age

Delving deep into the molecular subtleties of a strain of mice engineered to age rapidly, scientists have found that an accumulation of genetic mutations prompts a cascade of programmed cell death that seems to underpin the aging process.

18 Jul 2005

NIPA levels act as switch regulating cell division

Cells control mitosis (cell division) by assembling a biochemical switch to block it or by disassembling the switch to trigger it, according to investigators at St. Jude Children's Research Hospital and the Technical University of Munich.

18 Jul 2005

Oxytocin raises aggression, cuts anxiety during lactation

Maternal aggressive/protective behavior is recognized throughout mammalian species, especially during lactation. When hiking, we warn our kids not to approach bear cubs, or to get between a cub and the mother. While driving and you see a fawn, you know a doe can't be too far away and will run headlong to protect it.

18 Jul 2005

New method may accelerate the way cancer-causing genes are found

Researchers at the University of Minnesota Cancer Center and the National Cancer Institute (NCI) have discovered a new method that could accelerate the way cancer-causing genes are found and could lead to a more accurate identification of the genes, according to two studies in the July 14, 2005, issue of Nature.

13 Jul 2005

Researchers clarifiy role of Notch protein in T-cell development

Researchers at the University of Pennsylvania School of Medicine have recently clarified the role of the Notch protein in T-cell development. T cells are required for many aspects of immunity, including fighting viral infections, providing cancer surveillance, and regulating multiple aspects of the immune response.

6 Jul 2005