Cell Signaling News and Research

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Cell signaling is vital for cells to communicate and coordinate their activities, not just in the human body, but in all organisms. There are thousands of signaling pathways, ranging from protein homeostasis to carcinogenesis and biofilm formation.

Lipid signaling from beta cells linked to inflammatory macrophage polarization

Do the insulin-producing beta cells in the pancreas unwittingly produce a signal that aids their own demise in Type 1 diabetes?

23 Feb 2020

Combination therapy for pediatric low-grade gliomas shows promise in mice

In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer drug called trametinib may be more effective than either drug alone in decreasing the growth of pediatric low-grade gliomas.

17 Feb 2020

Georgia State researcher receives $1.67 million federal grant to study gut immunity

Dr. Tim Denning, professor and associate director of the Institute for Biomedical Sciences at Georgia State University, has received a four-year, $1.67 million federal grant to study how an immunological pathway influences inflammatory signaling in the intestine that can lead to chronic human diseases such as inflammatory bowel disease.

9 Feb 2020

Discovery about how cancer cells hide from the immune system could improve treatments

Researchers have shed light on the mechanism through which cancer cells become camouflaged to escape immune system detection and attack.

31 Jan 2020

Choice of anesthetic for breast tumor resection may influence cancer outcomes

A study led has added to the evidence that the type of anesthetic administered to cancer patients during tumor surgical resection may affect cancer outcomes.

31 Jan 2020

MSU researcher makes strides in discovering new cellular mechanism

A Montana State University biotechnology researcher was part of an international team that recently discovered an internal mechanism which may protect human cells from oxidative damage.

30 Jan 2020

NAU scientists study zebrafish to find powerful melanoma-fighting drugs

Melanoma is the most lethal type of skin cancer and unusually common in Arizona, where residents are exposed to higher-than-average amounts of ultraviolet radiation. However, Northern Arizona University scientists believe the formula for a combination of melanoma-fighting drugs is within reach.

21 Jan 2020

UT Southwestern study identifies new vulnerability in kidney tumors

A UT Southwestern researcher led a team that identified a new vulnerability in kidney tumors, the 10th most common cause of cancer death in men and women.

17 Jan 2020

NAU scientists in search of a powerful combination of melanoma-fighting drugs

Melanoma is the most lethal type of skin cancer and unusually common in Arizona, where residents are exposed to higher-than-average amounts of ultraviolet radiation.

13 Jan 2020

Study suggests average body temperature in humans falling

For decades, people have considered the average human body temperature to be 98.6 F, or 37 degrees Celsius. However, a new study published January 7, 2020, in the journal eLifeindicates this may no longer be the norm – and the researchers suggest a reason for their observed drop in average temperature.

13 Jan 2020

Researchers analyze molecular characteristics of cerebrospinal fluid from LMM patients

Patients with advanced melanoma who develop metastases in the leptomeninges, the fluid filled membranes surrounding the brain and spinal cord, have an extremely dismal prognosis. Most patients only survive for 8 to 10 weeks after diagnosis.

11 Jan 2020

Certain cancer drugs could be used in the future to treat COPD

New research has shown the potential for clinically available cancer treatments to treat chronic obstructive pulmonary disease.

6 Jan 2020

Scientists explain how a common virus causes havoc on bone marrow, organ transplant patients

For the first time, scientists have discovered the molecular mechanism behind how a common virus can wreak havoc on bone marrow and organ transplant patients, according to a paper published in the journal Cell & Host Microbe.

19 Dec 2019

New antibody shows promise in active lupus

A new trial involving the use of an antibody called anifrolumab reports improvement in patients with systemic lupus erythematosus (SLE) after 52 weeks of treatment. The research, titled 'Trial of Anifrolumab in Active Systemic Lupus Erythematosus', is published in the New England Journal of Medicine.

19 Dec 2019

Research finds key reason why brain connectivity goes awry in rare neurodevelopmental conditions

Axons are the long thread-like extensions of neurons that send electrical signals to other brain cells. Thanks to axonal connectivity, our brains and bodies can do all necessary tasks.

16 Dec 2019

Scientists uncover new link between pathways involved in RNA degradation

A recent study by a team of scientists in Korea reveals new findings about how various systems involved in cellular surveillance interact. This research is the first to identify a "cross-talk" molecule between these systems. Because these pathways are involved in fighting toxic cellular or foreign substances, the study has various potential applications in antiviral development, gene therapy, and agriculture.

6 Dec 2019

Attacking HIV at the source

A new study published on November 26, 2019, in the journal Cell Reports, details a new discovery that may help avert HIV infection right at the start. The virus is known to take a long time to infect a person, and the scientists say they have found a period during which it can be weakened or killed, in the very first hours after it has entered a host. They call this the window of vulnerability.

26 Nov 2019

Research shows how cilia and exocyst contribute to extracellular vesicle production

Although the cilium has been known to scientists for more than 100 years, it is only recently that it has been acknowledged to play important roles in physiology.

25 Nov 2019

UC Davis study identifies mechanism to rapidly repair leaky gut in monkeys with SIV infections

A UC Davis study found that the damaged gut lining (known as leaky gut) in monkeys infected with chronic simian immunodeficiency virus (SIV), an HIV-like virus, was rapidly repaired within five hours of receiving Lactobacillus plantarum bacteria.

19 Nov 2019

Uncovering the secret weapon of rabies viruses

In a new study published in the journal Cell Reports, scientists have discovered the exact site at which the immune system is disabled by the rabies virus, opening the way for a new and highly effective means of rabies prevention. This is a long-awaited discovery and could transform the field of rabies immunization.

13 Nov 2019