Cleft Palate News and Research

RSS

Cleft lip and cleft palate are birth defects that affect the upper lip and roof of the mouth. They happen when the tissue that forms the roof of the mouth and upper lip don't join before birth. The problem can range from a small notch in the lip to a groove that runs into the roof of the mouth and nose. This can affect the way the child's face looks. It can also lead to problems with eating, talking and ear infections.

Good news for young male cancer patients

"Young men undergoing treatment for cancer often want to know how the disease and its treatment affect their chances of fathering healthy children. Our large-scale study shows that there is a slightly higher risk of deformities, but the actual risk of having a child with deformities is nevertheless extremely low. I think this is good news!"

14 Dec 2008

Smoking when pregnant doubles risk of cleft palate or lip in babies

Babies whose mothers smoked during pregnancy were more than twice as likely to have a cleft palate or lip as those whose mothers didn't, according to research results released today.

6 Nov 2008

Birth defects more common if pregnant mothers smoke

New research has revealed that women who smoke during pregnancy are more likely to have a baby with a birth defect - smoking during pregnancy apparently doubles the risk of the baby having a cleft lip or palate.

5 Nov 2008

Researchers discover how Sonic hedgehog gene controls brain development

University of Pennsylvania School of Medicine researchers have discovered how the expression of the Sonic hedgehog gene is regulated during brain development and how mutations that alter this process cause brain malformations. The results appear online this month in Nature Genetics.

28 Oct 2008

Discovery of new gene responsible for puberty disorders

A new gene responsible for some puberty disorders has been identified by Medical College of Georgia researchers.

27 Oct 2008

Discovery of gene variant for cleft lip

About 20 percent of isolated cleft lip, one of the world's most common birth defects, may be due to a one-letter difference in the DNA sequence of a gene involved in facial development, researchers supported by the National Institutes of Health report.

6 Oct 2008

Researchers identify molecular mechanism underlying a genetic brain malformation called holoprosencephaly

St. Jude Children's Research Hospital scientists have identified one of the molecular mechanisms underlying the genetic brain malformation called holoprosencephaly (HPE).

11 Aug 2008

Binge drinking in pregnancy increases risk of oral clefts in offspring

A new study by researchers at the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, shows that pregnant women who binge drink early in their pregnancy increase the likelihood that their babies will be born with oral clefts.

31 Jul 2008

California Legislature takes up multiple health care bills

"More than a dozen health bills are advancing through the [California] Legislature," some of which contain elements of a health care overhaul plan backed by Gov. Arnold Schwarzenegger (R) that passed the state Assembly but was rejected in the Senate earlier this year, the Los Angeles Times reports.

8 Jun 2008

By-products of water chlorination linked to birth defects

Drinking water disinfected by chlorine while pregnant may increase the risk of having children with heart problems, cleft palate or major brain defects, according to a study published today in BioMed Central's open access journal Environmental Health.

2 Jun 2008

Palatal surgery in less lexically advanced, younger children associated with better speech outcomes

A new study published in The Cleft Palate-Craniofacial Journal has found that the timing of palatal surgery and size of lexicon, or vocabulary, in children are important factors to consider in determining the most beneficial management of children with cleft palate.

15 May 2008

New surgical device earns high marks from combat surgeons

Results of an independent clinical study conducted by U.S. Army combat support surgeons in Baghdad show that a new medical device used to close a type of surgical wound more quickly is saving lives and limbs of soldiers and civilians.

2 May 2008

Discovery of gene behind clefting disorder Branchio-Oculo-Facial syndrome

In a collaborative effort, researchers from Boston University School of Medicine (BUSM) have discovered that deletions or mutations within the TFAP2A gene (Activating Enhancer-Binding Protein) result in the distinctive clefting disorder Branchio-Oculo-Facial syndrome (BOFS).

23 Apr 2008

Discovery of previously unknown mechanism that leads to cleft palate

By creating a genetic mutation in zebrafish, University of Oregon scientists say they've discovered a previously unknown mechanism for cleft palate, a common birth defect in humans that has challenged medical professionals for centuries.

12 Feb 2008

Cellcept immunosuppressant further linked to birth defects

A new study documents malformations seen in an infant born to a kidney transplant recipient who had taken mycophenolate mofetil (MMF), a widely used immunosuppressant available commercially as Cellcept.

7 Feb 2008

Collaboration between Eastern and Western healthcare practitioners is needed

Recent study findings from The Cleft Palate–Craniofacial Journal stress the importance of culturally sensitive rehabilitative practices, collaboration, referrals and information sharing between Eastern and Western health care practitioners.

13 Nov 2007

Transplant rejection drug boosts the risk of birth defects

Authorities in the United States have issued a warning with regard to a drug used to prevent the rejection of transplanted organs.

30 Oct 2007

Educating local physicians key to care of children with cleft deformities in Zimbabwe

A surgical team that traveled to Zimbabwe successfully treated 39 children with cleft lip or palate, and an ongoing relationship with physicians there will help meet the needs of local patients, according to an article that will appear in the November/December 2007 print issue of Archives of Facial Plastic Surgery, one of the JAMA/Archives journals.

22 Oct 2007

Folic acid helps prevent facial cleft

A new study finds that women who take folic acid supplements early in their pregnancy can substantially reduce their baby's chances of being born with a facial cleft.

5 Sep 2007

How cells change the pace of their steps

Scientists at UC San Diego have discovered how cells of higher organisms change the speed at which they move, a basic biological discovery that may help researchers devise ways to prevent cancer cells from spreading throughout the body.

7 Aug 2007