Clinical Trial News and Research

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Immune modulation therapy, latest treatment for people with chronic heart failure

Here is the latest treatment for people with chronic heart failure: a nurse draws blood from the patient, runs that blood through a machine, superheating and “stressing” the blood, and then, injects it back into the patient.

29 Jun 2004

Exelixis files new drug application for a proprietary novel anticancer compound

Exelixis, Inc. has submitted an investigational new drug application (IND) to the U.S. Food and Drug Administration (FDA) for XL999, a proprietary novel anticancer compound.

29 Jun 2004

Alzheimer’s Society expresses concern over new study on dementia drug effectiveness, published in The Lancet

The Alzheimer’s Society has expressed serious concern at the interpretation of a new study into the effectiveness of drugs for dementia, published in The Lancet.

25 Jun 2004

Answers to childhood asthma may be in herbal medicine

A clinical trial to determine whether a herbal medicine can ease the symptoms of asthma in children is underway at RMIT University.

24 Jun 2004

Drug companies spend about 37% of their overall R&D budgets on clinical affairs

Over the last decade, clinical services industry growth has exploded. Today, study sponsors dedicate significant portions of their budgets to CROs, SMOs and patient recruiters to access the expertise needed to speed trials to safe and successful fruition.

23 Jun 2004

Paclitaxel analog kills more cancer cells than natural product

Paclitaxel, a natural compound from yew trees, is the world's best-selling anticancer drug. Several analogs are in clinical trial, with others in preclinical development. One problem that paclitaxel and all its analogs share, however, is that they are all highly complex compounds, and cannot be prepared synthetically in a commercially viable way.

21 Jun 2004

Pharmaxis completes interim analysis on Bronchitol study

Sydney-based pharmaceutical company Pharmaxis Ltd has conducted an interim analysis on the Phase IIb clinical trial evaluating Bronchitol™ in patients with the respiratory condition bronchiectasis.

21 Jun 2004

Harmless virus known as GBV-C slows the progression of HIV

Iowa City Veterans Affairs (VA) Medical Center and University of Iowa (UI) researchers have unlocked part of the mystery of how a harmless virus known as GBV-C slows the progression of HIV and prolongs survival for many patients.

17 Jun 2004

Genetically engineered thyroid stimulating hormone destroys tissue that often remains after thyroidectomy

A new approach to therapy can avoid most of the debilitating effects of preparing for critical, postsurgical treatment for patients with thyroid cancer, according to an international study led by researchers from Johns Hopkins and the University of Pisa.

16 Jun 2004

More research needed to determine if laser therapy is an effective treatment for acne

Additional research is needed before laser therapy can be recommended as a treatment for acne, according to a study in the June 16 issue of the Journal of the American Medical Association (JAMA).

15 Jun 2004

Expansion of Medicare coverage of positron emission tomography to include some Medicare beneficiaries with suspected Alzheimer’s disease

The Centers for Medicare & Medicaid Services (CMS) announced today that it intends to expand Medicare coverage of positron emission tomography (PET) to include some Medicare beneficiaries with suspected Alzheimer’s disease.

15 Jun 2004

Investigational drug Abraxane is active and well tolerated in women with metastatic breast cancer

Investigational drug Abraxane™ (albumin nanoparticle paclitaxel), administered weekly without steroid premedication, is active and well tolerated in women with metastatic breast cancer whose disease had progressed while they were treated with paclitaxel (Taxol®) and/or docetaxel (Taxotere®).

15 Jun 2004

African-American women less likely to survive breast cancer than white women

A new study led by investigators at Fred Hutchinson Cancer Research Center may help explain why African-American women with breast cancer are more likely to be diagnosed with advanced disease and are less likely to survive the disease than white women.

15 Jun 2004

Topiramate may protect newborns from brain injury and long-term neurologic problems caused by excitotoxicity

An existing drug already approved by the FDA may protect newborns from brain injury and long-term neurologic problems caused by excitotoxicity, or over-activation of neurons, report two NIH-funded studies from Children's Hospital Boston.

14 Jun 2004

Racial and ethnic minorities, women, and the elderly were less likely to enroll in cancer clinical trials than whites, men, and younger patients

According to background information provided by the authors, "Ten years have passed since Congress responded to concerns about unequal access to clinical trials and enacted the National Institutes of Health (NIH) Revitalization Act, which encouraged representation of women and minority patients in NIH-sponsored research.

14 Jun 2004

Research shows there is no substitute for reliable birth control

US research published (Thursday 10 June) in Europe's leading reproductive medicine journal Human Reproduction suggests that a single act of unprotected intercourse is more likely to lead to an unwanted pregnancy than was previously believed.

12 Jun 2004

Cannabis extract drug may help patients with rheumatoid arthritis

The multi centre double blind, randomised, parallel group study in 58 patients assessed the efficacy, safety and tolerability of Sativex®, a whole plant medicinal cannabis extract, compared with placebo for the treatment of pain caused by Rheumatoid Arthritis. Study medication was administered by means of a spray into the mouth as an evening dose only and measures were assessed the following day.

11 Jun 2004

New treatment significantly improves long-term outlook for breast cancer survivors

An updated analysis from an international clinical trial of the drug letrozole was presented on June 8, 2004 at the American Society of Clinical Oncology annual meeting in New Orleans.

11 Jun 2004

Drug commonly used for diabetes might be effective in treating multiple sclerosis

Researchers at the University of Illinois at Chicago are launching a clinical trial to determine whether a drug commonly used for diabetes might be effective in treating multiple sclerosis, an autoimmune disease that affects 350,000 Americans.

10 Jun 2004

Drug may benefit patients suffering deep scarring after radiation treatment

Cancer patients who suffer from a progressive, deep scarring of tissue following radiation treatment might benefit from a drug that’s FDA-approved to treat vascular disease, according to a University of Rochester study published in this month’s Journal of Clinical Oncology.

10 Jun 2004

Clinical Trial News and Research

Immune modulation therapy, latest treatment for people with chronic heart failure

Exelixis files new drug application for a proprietary novel anticancer compound

Alzheimer’s Society expresses concern over new study on dementia drug effectiveness, published in The Lancet

Answers to childhood asthma may be in herbal medicine

Drug companies spend about 37% of their overall R&D budgets on clinical affairs

Paclitaxel analog kills more cancer cells than natural product

Pharmaxis completes interim analysis on Bronchitol study

Harmless virus known as GBV-C slows the progression of HIV

Genetically engineered thyroid stimulating hormone destroys tissue that often remains after thyroidectomy

More research needed to determine if laser therapy is an effective treatment for acne

Expansion of Medicare coverage of positron emission tomography to include some Medicare beneficiaries with suspected Alzheimer’s disease

Investigational drug Abraxane is active and well tolerated in women with metastatic breast cancer

African-American women less likely to survive breast cancer than white women

Topiramate may protect newborns from brain injury and long-term neurologic problems caused by excitotoxicity

Racial and ethnic minorities, women, and the elderly were less likely to enroll in cancer clinical trials than whites, men, and younger patients

Research shows there is no substitute for reliable birth control

Cannabis extract drug may help patients with rheumatoid arthritis

New treatment significantly improves long-term outlook for breast cancer survivors

Drug commonly used for diabetes might be effective in treating multiple sclerosis

Drug may benefit patients suffering deep scarring after radiation treatment

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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