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Study reveals how genetic changes in SCN2A gene impact autism and epilepsy

A genetic change or variant in a gene called SCN2A is a known cause of infantile seizures, autism spectrum disorder and intellectual disability, as well as a wide range of other moderate-to-profound impairments in mobility, communication, eating and vision.

26 Apr 2024

Single dose of malaria monoclonal antibody 77% effective in children, trial in Mali shows

One injected dose of an experimental malaria monoclonal antibody was 77% effective against malaria disease in children in Mali during the country's six-month malaria season, according to the results of a mid-stage clinical trial.

26 Apr 2024

Japanese researchers test cardiac spheroids for heart regeneration in monkeys

Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function.

26 Apr 2024

First UK real-world study shows promise for sacituzumab govitecan in metastatic breast cancer

The real-world safety and efficacy of sacituzumab govitecan (SG) against metastatic triple-negative breast cancer.

26 Apr 2024

AI in healthcare shows promise in trials but needs real-world testing to ensure effectiveness

A comprehensive study published in The Lancet Digital Health analyzed the efficacy and challenges of AI in clinical settings, revealing a critical need for real-world testing and diverse research methodologies to ensure AI's reliable integration into healthcare.

25 Apr 2024

Insilico Medicine's AI-designed drug ISM3412 receives FDA IND approval

Clinical stage artificial intelligence (AI)-driven drug discovery company Insilico Medicine announces that it has received approval from the U.S. Food and Drug Administration for its Investigational New Drug application for ISM3412, a small molecule inhibitor of MAT2A for the potential treatment of MTAP deleted cancers designed with Insilico's generative AI platform.

25 Apr 2024

Genetic variants linked to Parkinson's risk from pesticide exposure

A new UCLA Health study found certain genetic variants could help explain how long-term pesticide exposure could increase the risk of Parkinson's disease.

25 Apr 2024

Reduction of prenatal depression associated with higher full-term birth rates

The effect of lowering prenatal mother depression on gestational duration.

25 Apr 2024

CASGEVY gene therapy eliminates vaso-occlusive crises in sickle cell patients

In a landmark study, an international consortium led by researchers at Children's Hospital of Philadelphia (CHOP) published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs).

24 Apr 2024

Novel immunotherapy shows promise for high-risk sarcomas: HEROS 2.0 trial results published

Researchers at Texas Children’s Cancer Center and the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children’s Hospital and Houston Methodist published results of a phase I clinical trial of a novel immunotherapy for high-risk sarcomas in the journal Nature Cancer.

24 Apr 2024

Study links poor heart health in Black women to midlife cognitive decline

A new study has found that Black women with poor cardiovascular health may face an elevated risk of early signs of cognitive decline in midlife.

24 Apr 2024

Better cardiovascular health among middle-aged Black women linked to less decline in cognition

Better heart health was linked to less decline in mental processing speed and cognition among middle-aged Black women, although not among middle-aged white women, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

24 Apr 2024

FDA approval of Anktiva heralds a new era in the treatment of BCG-unresponsive non–muscle-invasive bladder cancer

The U.S. Food and Drug Administration (FDA) has approved the immunotherapy-boosting drug N-803, which is marketed under the brand name Anktiva, to be used in combination with the immunotherapy Bacillus Calmette-Guerin (BCG) for the treatment of patients with BCG-unresponsive non–muscle-invasive bladder cancer.

23 Apr 2024

CN Bio raises $21 million USD in first close of Series B investment round

Bayland Capital and founding shareholder, CN Innovations Holdings Ltd, to invest $10 M and $5.5 M, respectively. Investment will expand product development and scaling of the organization to meet increased demand for Organ-on-a-Chip (OOC) solutions.

23 Apr 2024

The vital role of therapeutic alliances in psychedelic treatment

Drug effects have dominated the national conversation about psychedelics for medical treatment, but a new study suggests that when it comes to reducing depression with psychedelic-assisted therapy, what matters most is a strong relationship between the therapist and study participant.

23 Apr 2024

Korean fermented food Doenjang shows promise in alleviating menopausal symptoms

Study compares the effects of traditional versus commercial Korean Doenjang on menopausal symptoms, finding that traditional variants with high beneficial microorganisms are more effective in reducing these symptoms and improving cardiovascular and gut health.

21 Apr 2024

Dietary treatments outperform medications for IBS management

Dietary treatment is more effective than medications in irritable bowel syndrome (IBS). These are the findings of a study conducted at the University of Gothenburg.

18 Apr 2024

Researchers receive NIH grant to help develop gene therapy for HIV

Researchers at Washington University School of Medicine in St. Louis have received a $6.2 million grant from the National Institutes of Health (NIH) to develop a gene therapy that would modify the immune system's B cells to spur them to produce broadly neutralizing antibodies against HIV.

18 Apr 2024

New trials show promise for immune checkpoint blockers in early-stage lung cancer

A dendritic cell (DC) vaccine targeting patient-specific neoantigens to patients with resected non-small cell lung cancer (NSCLC).

18 Apr 2024

Breakthrough imaging method enhances precision in prostate cancer treatment

A novel SPECT/CT acquisition method can accurately detect radiopharmaceutical biodistribution in a convenient manner for prostate cancer patients, opening the door for more personalized treatment.

17 Apr 2024

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Clinical Trial News and Research

Study reveals how genetic changes in SCN2A gene impact autism and epilepsy

Single dose of malaria monoclonal antibody 77% effective in children, trial in Mali shows

Japanese researchers test cardiac spheroids for heart regeneration in monkeys

First UK real-world study shows promise for sacituzumab govitecan in metastatic breast cancer

AI in healthcare shows promise in trials but needs real-world testing to ensure effectiveness

Insilico Medicine's AI-designed drug ISM3412 receives FDA IND approval

Genetic variants linked to Parkinson's risk from pesticide exposure

Reduction of prenatal depression associated with higher full-term birth rates

CASGEVY gene therapy eliminates vaso-occlusive crises in sickle cell patients

Novel immunotherapy shows promise for high-risk sarcomas: HEROS 2.0 trial results published

Study links poor heart health in Black women to midlife cognitive decline

Better cardiovascular health among middle-aged Black women linked to less decline in cognition

FDA approval of Anktiva heralds a new era in the treatment of BCG-unresponsive non–muscle-invasive bladder cancer

CN Bio raises $21 million USD in first close of Series B investment round

The vital role of therapeutic alliances in psychedelic treatment

Korean fermented food Doenjang shows promise in alleviating menopausal symptoms

Dietary treatments outperform medications for IBS management

Researchers receive NIH grant to help develop gene therapy for HIV

New trials show promise for immune checkpoint blockers in early-stage lung cancer

Breakthrough imaging method enhances precision in prostate cancer treatment

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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