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Overcoming cancer relapse with CAR-Enhancer therapy

Even as they have revolutionized the treatment of certain forms of cancer, CAR T-cell therapies have been shadowed by a significant limitation: many patients, including those whose cancer goes into full remission, eventually relapse. In a new study, Dana-Farber Cancer Institute researchers report on a technique with the potential to eliminate that problem.

26 Jul 2024

Medicaid policies boost oncology clinical trial enrollment for Black and Hispanic patients

Two Medicaid policies can interact to increase oncology clinical trial enrollment among Black and Hispanic patients, according to a new study by investigators at Weill Cornell Medicine, the University of Pennsylvania, and Medidata AI.

25 Jul 2024

Experimental cancer drug may help clear HIV from infected cells in the brain

An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new Tulane University study.

25 Jul 2024

Insilico Medicine's PandaOmics Box enhances drug discovery with advanced AI capabilities

The development of innovative medicines is an expensive, time-consuming and risky business. On average, it usually takes at least a decade and billions of dollars to bring a new drug from project initiation to approval.

25 Jul 2024

UK initiative aims to transform MND research through health data collaboration

MND is a devastating disease affecting the motor neurones in the brain and spinal cord, leading to progressive muscle weakness and paralysis.

25 Jul 2024

Posterior foraminotomy shows comparable results to anterior discectomy for cervical radiculopathy

For patients with cervical radiculopathy, posterior foraminotomy provides outcomes comparable to those of the more commonly performed anterior cervical discectomy, reports a randomized clinical trial in The Journal of Bone & Joint Surgery.

25 Jul 2024

Fecal microbiota transplants can boost the effectiveness of immunotherapy in gastrointestinal cancers

Findings from a small, proof-of-concept clinical trial have suggested that fecal microbiota transplants (FMTs) can boost the effectiveness of immunotherapy in a range of gastrointestinal cancers.

25 Jul 2024

Texas Heart Institute and BiVACOR achieve milestone with total artificial heart implantation

The Texas Heart Institute (THI) and BiVACOR, a clinical-stage medical device company, announced today the successful first-in-human implantation of the BiVACOR Total Artificial Heart (TAH) as part of the U.S. Food and Drug Administration (FDA) Early Feasibility Study (EFS) on July 9, 2024.

25 Jul 2024

Study confirms esaxerenone as a safe and effective alternative for hypertension treatment

Researchers find that esaxerenone is a non-inferior alternative to trichlormethiazide for treating uncontrolled hypertension in Japanese patients. The study confirms similar safety profiles for both drugs.

25 Jul 2024

$Study shows wearable health sensors only prompt a fraction of at-home tests$

Study shows wearable health sensors only prompt a fraction of at-home tests

When seemingly healthy people receive an alert from a wearable sensor telling them they might have a respiratory virus-;based on small changes in their unique heartrate, sleep and activity patterns-;what do they do? According to a new study by Scripps Research scientists carried out at the height of the COVID-19 pandemic, only a quarter of people follow up such an alert with an at-home viral test.

24 Jul 2024

Wearable devices can amplify anxiety in people with Afib

Using a wearable device, such as a smart watch, to track health data and symptoms, is supposed to help people monitor their health and address symptoms as quickly as possible to spur positive health outcomes.

24 Jul 2024

Community pharmacists help close gaps in stroke prevention for Afib patients

Atrial fibrillation (Afib) is the most common heart rhythm disorder encountered in clinical practice according to Dr. Roopinder Sandhu, MD, MPH, and the leading cause of stroke in older individuals.

24 Jul 2024

Kaempferol's promise in fighting triple-negative breast cancer

Review highlights kaempferol's potential in treating triple-negative breast cancer through various anticancer mechanisms and improving chemotherapeutic efficacy.

24 Jul 2024

Personalized text messages effectively promote increased physical activity after cardiovascular events

Exercise is one of the best ways to reduce your risk of heart disease or having a second cardiovascular event, such as a heart attack or stroke.

24 Jul 2024

Comprehensive dataset from A4 study yields key insights about Alzheimer's disease

Data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) study, the first and largest clinical trial of pre-symptomatic Alzheimer's disease, is now widely available to researchers studying the condition.

24 Jul 2024

Dietary interventions improve mitochondrial function and reduce inflammation in obesity

Study demonstrates that dietary interventions such as calorie restriction, intermittent fasting, and ketogenic diet improve mitochondrial function in monocytes and reduce inflammation in obesity by modulating gut microbiota.

23 Jul 2024

Study validates Stockholm3 test for prostate cancer in ethnically mixed populations

Stockholm3, a prostate cancer test developed in Sweden, runs a combination of protein and genetic markers from a blood sample through an algorithm to find the probability of a patient having clinically significant cancer.

23 Jul 2024

Abacavir linked to increased cardiovascular risk in HIV patients, study finds

CJ Fichtenbaum et al. Abacavir is associated with elevated risk for cardiovascular events in the REPRIEVE trial. International AIDS Conference. Friday, July 26, 2024

23 Jul 2024

New preclinical model offers a unique platform for studying Parkinson's disease process

A new preclinical model offers a unique platform for studying the Parkinson's disease process and suggests a relatively easy method for detecting the disease in people, according to a new study led by Weill Cornell Medicine researchers.

23 Jul 2024

PrEPVacc HIV vaccine trial shows no reduction in infections

The results of the PrEPVacc HIV vaccine trial conducted in Eastern and Southern Africa, which ran between 2020 and 2024, show conclusively that neither of the two experimental vaccine regimens tested reduced HIV infections among the study population.

23 Jul 2024

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Clinical Trial News and Research

Overcoming cancer relapse with CAR-Enhancer therapy

Medicaid policies boost oncology clinical trial enrollment for Black and Hispanic patients

Experimental cancer drug may help clear HIV from infected cells in the brain

Insilico Medicine's PandaOmics Box enhances drug discovery with advanced AI capabilities

UK initiative aims to transform MND research through health data collaboration

Posterior foraminotomy shows comparable results to anterior discectomy for cervical radiculopathy

Fecal microbiota transplants can boost the effectiveness of immunotherapy in gastrointestinal cancers

Texas Heart Institute and BiVACOR achieve milestone with total artificial heart implantation

Study confirms esaxerenone as a safe and effective alternative for hypertension treatment

Study shows wearable health sensors only prompt a fraction of at-home tests

Wearable devices can amplify anxiety in people with Afib

Community pharmacists help close gaps in stroke prevention for Afib patients

Kaempferol's promise in fighting triple-negative breast cancer

Personalized text messages effectively promote increased physical activity after cardiovascular events

Comprehensive dataset from A4 study yields key insights about Alzheimer's disease

Dietary interventions improve mitochondrial function and reduce inflammation in obesity

Study validates Stockholm3 test for prostate cancer in ethnically mixed populations

Abacavir linked to increased cardiovascular risk in HIV patients, study finds

New preclinical model offers a unique platform for studying Parkinson's disease process

PrEPVacc HIV vaccine trial shows no reduction in infections

E-Cigarettes and Ethanol: A forensic Perspective on Vaping

Understanding Consumer-Consented Data to Optimize Digital Health Programs

The Future is Wearable: Advancing Human Health Through Portable Spectroscopy

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