Clinical Trial News and Research

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Gene therapy restores vision in patients with rare congenital blindness

In a clinical trial at The Children's Hospital of Philadelphia, researchers from The University of Pennsylvania have used gene therapy to safely restore vision in three young adults with a rare form of congenital blindness.

27 Apr 2008

U.S., British HIV/AIDS researchers pessimistic about prospects of vaccine, survey finds

Leading HIV/AIDS researchers in Britain and the U.S. are pessimistic about the prospects of developing an HIV vaccine following the recent failure of a Merck vaccine candidate, according to a survey conducted by London's Independent, the Independent reports (Connor/Green, Independent, 4/24).

26 Apr 2008

Combining sorafenib with carboplatin/paclitaxel adds no benefit in lung cancer

A clinical trial evaluating the benefit of adding the drug sorafenib to the combination of carboplatin/paclitaxel chemotherapy for lung cancer patients has been stopped based on results from an interim analysis, after an independent data monitoring committee concluded that the study would not meet its primary endpoint of improved overall survival.

26 Apr 2008

Cancer immunotherapy shows long-term promise in lung cancer

New, long-term results from a clinical trial presented at the 1st European Lung Cancer Conference jointly organized by the European Society for Medical Oncology (ESMO) and the International Association of the Study of Lung Cancer (IASLC) show that MAGE-A3 ASCI (Antigen-Specific Cancer Immunotherapeutic), an immune-boosting treatment for lung cancer patients, reduces the risk of relapse after surgery -- to the same extent as chemotherapy but without the side-effects of chemotherapy.

26 Apr 2008

Bioartificial kidney speeds recovery, reduces mortality

Another promising clinical trial for the bioartificial kidney is offering researchers even more hope that within the next few years the device will be available to save lives of patients with acute renal failure.

24 Apr 2008

DNA vaccines may offer hope in multiple sclerosis

Authors from the VA North Texas Health Care System Neurology Section and the Department of Neurology at the University of Texas Southwestern Medical Center at Dallas have highlighted the potential benefits for DNA-based vaccine administration in patients with multiple sclerosis (MS).

24 Apr 2008

Pralatrexate for T-cell lymphoma

The fifth leading cause of cancer in the United States, lymphoma is made up of more than 40 rare and highly diverse diseases that target the body's lymphatic system. Lymphomas include both one of the fastest growing cancers -- Burkitt's lymphoma, which can double in size in as little as a day -- and one of the slowest, chronic lymphocytic leukemia (CLL).

24 Apr 2008

Multiple studies demonstrate use of hyperthermia therapy in treating pancreatic cancer

BSD Medical Corporation has began to report highlights from 204 abstracts summarizing presentations at the International Congress on Hyperthermic Oncology (ICHO) conducted this month in Munich, Germany

24 Apr 2008

Simplified economical method of giving rabies vaccine

A simplified economical method of giving rabies vaccine is just as effective as the expensive standard vaccine regimen at stimulating anti-rabies antibodies.

23 Apr 2008

Discovery of protein that helps predict prostate cancer survival

An Oregon Health & Science University Cancer Institute researcher has identified a protein that is a strong indicator of survival for men with advanced prostate cancer. The C-reactive protein, also known as CRP, is a special type of protein produced by the liver that is elevated in the presence of inflammation.

22 Apr 2008

New advance in use of oncolytic viruses as novel cancer treatments

Combining a herpes virus genetically altered to express a drug-enhancing enzyme with a chemotherapy drug effectively and safely reduced the size of highly malignant human sarcoma grafted into mice.

22 Apr 2008

Lorus initiates development program exploring novel route of administration for LOR-2040

Lorus Therapeutics Inc. today announced the start of a development program aimed at expanding the therapeutic application of its lead clinical-stage drug LOR-2040 for the treatment of superficial bladder cancer.

22 Apr 2008

Angiotech to suspend Vascular Wrap clinical trials

Angiotech Pharmaceuticals, Inc. has announced that it has elected to suspend enrolment in its U.S. and EU human clinical trials for its Vascular Wrap product candidate in patients undergoing surgery for hemodialysis access, pending a safety review to evaluate an imbalance of infections that have been observed between the two study groups.

21 Apr 2008

New technology tracks medication adherence in patients with HIV/AIDS

Most of us have missed a dose of antibiotic or forgotten to take a daily vitamin. But when the stakes are higher - as they are for people with HIV/AIDS - a skipped pill could mean the difference between health and hazard for the entire population.

21 Apr 2008

BioAlliance Pharma announces preliminary results from U.S. phase III trial for Loramyc

BioAlliance Pharma SA today announced the preliminary positive results for its US pivotal Phase III clinical trial with Loramyc (miconazole Lauriad), Mucoadhesive Buccal Tablets (MBT) developed for the treatment of OroPharyngeal Candidiasis in immunocompromised population. This trial was conducted to support an NDA filing to market the product in the US.

21 Apr 2008

Peripheral arterial disease linked to too little vitamin D

According to the results of the latest research peripheral arterial disease (PAD) may be linked to low levels of vitamin D.

21 Apr 2008

Non-surgical heart valve replacement procedure permits swift recovery and discharge from hospital

Interventional cardiologists at Rush University Medical Center now offer a minimally-invasive transcatheter valve replacement procedure for patients with congenital heart disease that doesn’t involve open heart surgery.

18 Apr 2008

Iron nanoparticles spot tumor spread in patients with kidney cancer

Iron nanoparticles designed to collect in lymph nodes containing metastatic cancer cells have proven that they can help physicians detect metastatic spread of prostate cancer.

18 Apr 2008

The mechanism of phosphorus as a cardiovascular risk factor in chronic kidney disease

The estimated 19 million Americans living with chronic kidney disease (CKD) face a high risk of death from cardiovascular disease. Recent studies have shown that a main source of this cardiovascular risk is CKD patients' high levels of blood phosphate.

17 Apr 2008

Angiotech receives FDA clearance to market 5-Fluorouracil-coated central venous catheter

Angiotech Pharmaceuticals, Inc. has announced that it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market its innovative 5-Fluorouracil-coated (5-FU) Central Venous Catheter (CVC) in the United States.

17 Apr 2008

Clinical Trial News and Research

Gene therapy restores vision in patients with rare congenital blindness

U.S., British HIV/AIDS researchers pessimistic about prospects of vaccine, survey finds

Combining sorafenib with carboplatin/paclitaxel adds no benefit in lung cancer

Cancer immunotherapy shows long-term promise in lung cancer

Bioartificial kidney speeds recovery, reduces mortality

DNA vaccines may offer hope in multiple sclerosis

Pralatrexate for T-cell lymphoma

Multiple studies demonstrate use of hyperthermia therapy in treating pancreatic cancer

Simplified economical method of giving rabies vaccine

Discovery of protein that helps predict prostate cancer survival

New advance in use of oncolytic viruses as novel cancer treatments

Lorus initiates development program exploring novel route of administration for LOR-2040

Angiotech to suspend Vascular Wrap clinical trials

New technology tracks medication adherence in patients with HIV/AIDS

BioAlliance Pharma announces preliminary results from U.S. phase III trial for Loramyc

Peripheral arterial disease linked to too little vitamin D

Non-surgical heart valve replacement procedure permits swift recovery and discharge from hospital

Iron nanoparticles spot tumor spread in patients with kidney cancer

The mechanism of phosphorus as a cardiovascular risk factor in chronic kidney disease

Angiotech receives FDA clearance to market 5-Fluorouracil-coated central venous catheter

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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