Clopidogrel is an oral antiplatelet agent (thienopyridine class) to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.
Three drugs, each of which works in a different way, are used in anti-platelet therapy to help prevent restenosis (the reclogging of blood vessels after they have been cleared with percutaneous coronary intervention or PCI) or thrombosis (obstruction of an artery or vein by a blood clot).
While aspirin remains a crucial and cost-effective therapy for the prevention and management of cardiovascular diseases, research suggests that a significant percentage of the 25 million Americans on a chronic aspirin regimen are "aspirin resistant," or do not achieve sufficient antiplatelet effects from aspirin.
The widely used herbal remedy St. John's wort appears to amplify the action of the popular blood-thinning drug clopidogrel, sold as Plavix, a small new clinical study finds.
Physicians are challenged in treating heart patients who may be at high-risk for gastrointestinal bleeding from aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Factors that place patients at high-risk include a history of ulcers or gastrointestinal complications such as bleeding, increased age and congestive heart failure.
Although individual patients respond differently to treatment with the anti-platelet medication clopidogrel (brand name Plavix®), those variations appear normal and may not indicate important differences in the effectiveness of treatment, according to a new study (PDF file) in the Jan. 18, 2005 issue of the Journal of the American College of Cardiology.
The death rate during combination surgery to bypass clogged coronary arteries and simultaneously replace a heart valve in very sick patients can be as high as one in five, but a review of records of very sick patients who underwent balloon angioplasty, followed by heart valve replacement surgery, found only one death among 26 patients.
New antithrombotic guidelines from the American College of Chest Physicians (ACCP) introduce novel therapies for the prevention and treatment of thrombosis and, for the first time, offer specific recommendations for long-distance travelers.
Patients with chest pain are recognized as being at high risk of subsequent adverse cardiac events when their plasma levels of cardiac troponin are elevated as evidence of myocardial damage.
Popping an aspirin the night before you are due to have surgery on neck arteries could help prevent a dangerous complication, a team of researchers at the University of Leicester has discovered.