Colorectal News and Research

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Erbitux improves survival of mCRC patients with KRAS wild-type tumors

Merck Serono, a division of Merck KGaA, Darmstadt, Germany, today announced that Erbitux® (cetuximab) provided an improvement in overall survival (OS) when added to the standard 1st-line FOLFIRI chemotherapy regimen for metastatic colorectal cancer (mCRC) patients with KRAS wild-type tumors in the CRYSTAL study.

24 Jan 2010

Final data from Poniard Pharmaceuticals' randomized Phase 2 trial of picoplatin announced

Poniard Pharmaceuticals, Inc., a biopharmaceutical company focused on innovative oncology therapies, today announced final data from a randomized, controlled Phase 2 trial of picoplatin in metastatic colorectal cancer (CRC) patients.

24 Jan 2010

HealthPartners Medical Group to provide timely colorectal cancer screening for African American patients

HealthPartners Medical Group today announced that it has launched an initiative aimed at saving lives by providing more timely colorectal cancer screening for African American patients.

22 Jan 2010

Association between vitamin D and risk of colorectal cancer identified

High blood levels of vitamin D are associated with a lower risk of colon cancer, finds a large European study published on bmj.com today. The risk was cut by as much as 40% in people with the highest levels compared with those in the lowest.

22 Jan 2010

World’s first Cs-131 implant for colorectal cancer performed at Weill Cornell Medical Center

IsoRay, Inc., announced today that on October 10, 2009, Dr. Bhupesh Parashar, Dr. A Gabriella Wernicke and Dr. KS Clifford Chao from the Department of Radiation Oncology, and Dr. Jeffery Milsom from the Department of Gastrointestinal Surgery, at Weill Cornell Medical Center performed the world’s first Cesium-131(Cs-131) implant for the treatment of colorectal cancer.

21 Jan 2010

Amgen announces results of two Phase 3 studies evaluating Vectibix for mCRC

Amgen today announced that detailed results from two pivotal Phase 3 studies evaluating Vectibix® (panitumumab) in combination with chemotherapy for the first and second-line treatment of metastatic colorectal cancer (mCRC) (the PRIME '203' and '181' trials, respectively) will be presented at the 2010 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium in Orlando, Florida from Jan. 22-24, 2010.

21 Jan 2010

Fc engineering enhances antibody half-life

A Nature Biotechnology article published online January 17 reveals that Xencor Inc.’s proprietary Fc engineering extends the half-life of antibodies while maintaining their potency and extending duration of action. These results, published in an article entitled, “Enhanced antibody half-life improves in vivo activity” demonstrate the potential of Fc engineering to impact the flexibility of route, schedule and dose for nearly any antibody.

20 Jan 2010

Leafy green vegetables, folate and multivitamins can prevent lung cancer in smokers

Leafy green vegetables, folate, and some multivitamins could serve as protective factors against lung cancer in current and former smokers, according to a study that is a first step in understanding a complex association.

19 Jan 2010

Surveillance colonoscopy need to be better aligned with patients' risks for colorectal cancer

How often patients receive surveillance colonoscopy may need to be better aligned with their risks for colorectal cancer, according to two papers published this month by University of Pittsburgh School of Medicine researchers.

18 Jan 2010

Treatment for metastatic tumor based on its unique protein makeup

Imagine if treatments for disease could be based not on a patient's diagnosis but instead on the characteristics of their tissue. By identifying and decoding the cryptic messages hidden deep inside the human proteome, scientists and physicians who study personalized medicine are seeking more effective treatments and disease management for patients.

18 Jan 2010

Study results show increase of mortality due to colon cancer in Spain

There are stark geographical contrasts in the incidence of colon cancer worldwide. The new study analyses the causes of these disparities, starting with Spanish trends between 1951 and 2006 in terms of certain changes in consumption (tobacco, alcohol, red and processed meat, fish, vegetables...) and also behaviour (physical exercise, sedentary lifestyles-).

18 Jan 2010

Geisinger CEO wins 2010 TRUST Award

The Health Research & Educational Trust (HRET), an affiliate of the American Hospital Association (AHA), has selected Glenn D. Steele Jr., MD, PhD president and chief executive officer of Geisinger Health System, as the recipient of the 2010 TRUST Award.

18 Jan 2010

New research shows cutting tobacco smoking reduces cancer deaths in Europe

New research on deaths from cancer in Europe concludes that the key priority for continuing to reduce mortality is cutting tobacco smoking. The study shows that, while deaths for men from lung cancer in the EU have declined overall, by 17 % from 1995 to 2004, they rose by 27% for women over the same period.

17 Jan 2010

TD2 and COTI work together to obtain approval of clinical trials for COTI-2

TGen Drug Development (TD2) and Critical Outcome Technologies Inc. (COTI) (TSXV:COT) announced today that they will work together to obtain approval of clinical trials for a promising new anti-cancer drug called COTI-2.

12 Jan 2010

New blood test to identify changes in DNA linked with colorectal cancer now available in the U.S.

A new blood test that identifies changes in DNA associated with colorectal cancer is now available in the U.S. through Quest Diagnostics Incorporated, the world's leading cancer diagnostics company. The test is designed to aid the detection of colorectal cancer, the third leading cause of cancer-related deaths.

12 Jan 2010

National survey reveals many Canadians understand risk of colon cancer, but are not taking action

A new national survey reveals that while almost all Canadians understand the importance of getting checked for colon cancer, most have not had a screening test and are confused about how and when it should happen.

8 Jan 2010

CCAC doubles its efforts to convince Canadians to prevent colorectal cancer

Following the results of the Angus Reid Strategies and the Applied Health Research Centre at Toronto's St. Michael's Hospital survey conducted on behalf of the Canadian Partnership Against Cancer finding that the majority of Canadians have a good understanding of the benefits of colorectal cancer screening, but are not taking action to get screened, the Colorectal Cancer Association of Canada ("CCAC") is doubling its efforts in 2010 to convince Canadians that they must be more proactive concerning their health and the onset of colorectal cancer.

7 Jan 2010

Data highlights importance of follow-up exams for patients with history of advanced adenomas

A new study examines the occurrence of interval colorectal cancer despite regular colonoscopy and highlights the importance of close follow-up for patients who have a history of advanced adenomas, which are precancerous polyps.

7 Jan 2010

Enzon Pharmaceuticals treats first patient in Phase 2 studies of PEG-SN38

Enzon Pharmaceuticals, Inc. today announced that the first patient has been treated in the Phase 2 studies of PEG-SN38 for metastatic breast cancer. PEG-SN38 or EZN-2208 is Enzon’s PEGylated form of SN38, the active metabolite of the cancer drug Camptosar® (irinotecan HCl injection).

6 Jan 2010

Wisconsin rural hospitals hope for federal money to offset state Medicaid cut

Wisconsin's rural hospitals hope to offset a state Medicaid cut with a tax that would bring more federal money to the hospitals. The proposed tax on the state's 59 'critical access' hospitals, all in rural areas, would prevent the hospitals from closing important services, officials say.

5 Jan 2010

Colorectal News and Research

Erbitux improves survival of mCRC patients with KRAS wild-type tumors

Final data from Poniard Pharmaceuticals' randomized Phase 2 trial of picoplatin announced

HealthPartners Medical Group to provide timely colorectal cancer screening for African American patients

Association between vitamin D and risk of colorectal cancer identified

World’s first Cs-131 implant for colorectal cancer performed at Weill Cornell Medical Center

Amgen announces results of two Phase 3 studies evaluating Vectibix for mCRC

Fc engineering enhances antibody half-life

Leafy green vegetables, folate and multivitamins can prevent lung cancer in smokers

Surveillance colonoscopy need to be better aligned with patients' risks for colorectal cancer

Treatment for metastatic tumor based on its unique protein makeup

Study results show increase of mortality due to colon cancer in Spain

Geisinger CEO wins 2010 TRUST Award

New research shows cutting tobacco smoking reduces cancer deaths in Europe

TD2 and COTI work together to obtain approval of clinical trials for COTI-2

New blood test to identify changes in DNA linked with colorectal cancer now available in the U.S.

National survey reveals many Canadians understand risk of colon cancer, but are not taking action

CCAC doubles its efforts to convince Canadians to prevent colorectal cancer

Data highlights importance of follow-up exams for patients with history of advanced adenomas

Enzon Pharmaceuticals treats first patient in Phase 2 studies of PEG-SN38

Wisconsin rural hospitals hope for federal money to offset state Medicaid cut

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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