Coronary Heart Disease News and Research

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Higher testosterone levels in older women are associated with increased health risks

Postmenopausal women who have higher testosterone levels may be at greater risk of heart disease, insulin resistance and the metabolic syndrome compared to women with lower testosterone levels, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

4 Nov 2009

Dietary cholesterol is not a primary factor for coronary heart disease

Contrary to the established view, current data suggest that dietary cholesterol is not a primary factor of or causes heart disease - with the possible exception of the genetic forms of familial hypercholesterolemias. For instance, recent clinical trials evaluating the effect of cholesterol-lowering drugs on the development of chronic heart failure, diabetes and stroke have yielded disappointing results.

2 Nov 2009

BENLYSTA meets primary endpoint in BLISS-76 trial for systemic lupus erythematosus

Human Genome Sciences, Inc. and GlaxoSmithKline PLC (GSK) today announced that BENLYSTA™ (belimumab) met the primary endpoint in BLISS-76, the second of two pivotal Phase 3 trials in seropositive patients with systemic lupus erythematosus (SLE). BLISS-76 study results through 52 weeks showed that belimumab 10 mg/kg plus standard of care achieved a statistically significant improvement in patient response rate as measured by the SLE Responder Index at Week 52, compared with placebo plus standard of care.

2 Nov 2009

Recent releases in Global Health

"Action always leads to reaction, a fundamental law of nature," write the authors of an introduction appearing in a Journal of Acquired Immune Deficiency Syndromes (JAIDS) supplemental issue that focuses on global health systems.

30 Oct 2009

CCS updates the Canadian guidelines for the management and treatment of dyslipidemia

The management of dyslipidemia continues to evolve and despite improvements in recurrent cardiovascular events and a decrease in cardiac mortality, cardiovascular disease (CVD) still represents the major burden of disease in this country.

29 Oct 2009

Alnylam Pharmaceuticals announces participation in a $2.4M cardiovascular disease research grant

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today its participation in a $2.4 million research grant awarded to the University of Pennsylvania under the “American Recovery and Reinvestment Act of 2009”. The new grant will fund research over two years in the laboratories of Daniel Rader, M.D. of the University of Pennsylvania School of Medicine, Sekar Kathiresan, M.D. of Massachusetts General Hospital (MGH) and Harvard Medical School, and Alnylam.

29 Oct 2009

Routine use of HRT increases longevity in postmenopausal women

Hormone replacement therapy (HRT) to treat menopausal estrogen deficiency has been in widespread use for over 60 years. Several observational studies over the years showed that HRT use by younger postmenopausal women was associated with a significant reduction in total mortality; available evidence supported the routine use of HRT to increase longevity in postmenopausal women.

29 Oct 2009

Berkeley HeartLab enters into collaborative agreement

Berkeley HeartLab (BHL), a subsidiary of Celera Corporation, announced today that it has entered into collaborative agreements with Geisinger Medical Center and Proven Diagnostics, a clinical laboratory service recently launched by Geisinger Health System.

29 Oct 2009

Study reveals that adding ezetimibe to atorvastatin aids in reducing cholesterol

Edmonton - Adding ezetimibe to atorvastatin significantly boosted the attainment of lipid targets as specified by both Canadian and European guidelines in elderly patients aged 65 and older and the combination produced superior results than simply increasing the dose of atorvastatin alone, Dr. Christian Constance told the Canadian Cardiovascular Congress 2009, co-hosted by the Heart and Stroke Foundation and the Canadian Cardiovascular Society.

27 Oct 2009

New research may help in understanding mechanisms involved in blood flow-related disorders

Red blood cells, which make up 45 percent of blood, normally take the shape of circular cushions with a dimple on either side. But they can sometimes deform into an asymmetrical slipper shape. A team of physicists have used simulations to explore how fluid flow might be responsible for this deformation, as well as how the deformation in turn affects blood flow.

27 Oct 2009

Heart attacks in middle-aged women more common, says study

Heart attacks appear to have become more common in middle-aged women over the past two decades, but all women and especially those younger than 55 have recently experienced a greater increase than men in their chances of survival following such a heart event, according to two reports in the October 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

27 Oct 2009

Exercise and lifestyle changes are key to improve heart health

Exercise is a wonderful way of boosting heart health, but it's proving to be a tough sell in Ontario South Asian communities, Dr. Milan Gupta told the Canadian Cardiovascular Congress 2009, co-hosted by the Heart and Stroke Foundation and the Canadian Cardiovascular Society.

26 Oct 2009

Omega-3 fatty acid supplements do not improve levels of depression in heart disease patients

Contrary to the findings of some studies, new research indicates that augmenting antidepressant therapy with an omega-3 fatty acid supplement does not result in improvement in levels of depression in patients with coronary heart disease, according to a study in the October 21 issue of JAMA.

26 Oct 2009

Learn to recognise stroke symptoms and take action: World Stroke Organization

The theme of this year's World Stroke Day on 29th October is "What can I do?". As the World Stroke Organization says, everyone can do something: learn to recognise symptoms and take action, learn to recognise the risk factors and take action.

24 Oct 2009

Boehringer Ingelheim receives European CHMP positive opinion for MICARDIS

Boehringer Ingelheim announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Evaluation Agency (EMEA) has issued a positive opinion for the approval of MICARDIS® (telmisartan) for the reduction of cardiovascular morbidity.

23 Oct 2009

LIVALO statin effective than simvastatin in reducing lipid levels

New Phase III data published today in "Current Medical Research and Opinion" highlight that the recommended starting dose of 2 mg of LIVALO (pitavastatin), a novel synthetic statin, was statistically superior to simvastatin at a dose of 20 mg over 12 weeks in reducing low-density lipoprotein cholesterol

22 Oct 2009

Human Genome Sciences and GlaxoSmithKline to present Phase 3 trial results of BENLYSTA

Human Genome Sciences, Inc. and GlaxoSmithKline PLC (GSK) today announced the full presentation of results from BLISS-52, the first of two pivotal Phase 3 trials of BENLYSTA™ (belimumab) in seropositive patients with systemic lupus erythematosus (SLE).

20 Oct 2009

FDA approves Boehringer Ingelheim's MICARDIS for the reduction of risk of heart attack

Boehringer Ingelheim announced today that the US Food and Drug Administration (FDA) has approved a new indication for MICARDIS® (telmisartan) for the reduction of the risk of myocardial infarction (heart attack), stroke, or death from cardiovascular (CV) causes in patients 55 years of age or older at high risk of developing major CV events who are unable to take ACE inhibitors. MICARDIS® is the first treatment in its class to be approved for this indication.

19 Oct 2009

Unlike obesity, overweight does not increase mortality rate

Contrary to what was previously assumed, overweight is not increasing the overall death rate in the German population. Matthias Lenz of the Faculty of Mathematics, Computer Science, and Natural Sciences of the University of Hamburg and his co-authors present these and other results in the current issue of Deutsches -rtzeblatt International (Dtsch Artzebl Int 2009; 106[40]: 641𔃆).

19 Oct 2009

Inclusion of vitamin D values in National Nutrient Database

The next time you run nutritionals using the government's database, you might be pleasantly surprised that some of your favorite foods seem to have received a nutrient boost, virtually overnight.

9 Oct 2009

Coronary Heart Disease News and Research

Higher testosterone levels in older women are associated with increased health risks

Dietary cholesterol is not a primary factor for coronary heart disease

BENLYSTA meets primary endpoint in BLISS-76 trial for systemic lupus erythematosus

Recent releases in Global Health

CCS updates the Canadian guidelines for the management and treatment of dyslipidemia

Alnylam Pharmaceuticals announces participation in a $2.4M cardiovascular disease research grant

Routine use of HRT increases longevity in postmenopausal women

Berkeley HeartLab enters into collaborative agreement

Study reveals that adding ezetimibe to atorvastatin aids in reducing cholesterol

New research may help in understanding mechanisms involved in blood flow-related disorders

Heart attacks in middle-aged women more common, says study

Exercise and lifestyle changes are key to improve heart health

Omega-3 fatty acid supplements do not improve levels of depression in heart disease patients

Learn to recognise stroke symptoms and take action: World Stroke Organization

Boehringer Ingelheim receives European CHMP positive opinion for MICARDIS

LIVALO statin effective than simvastatin in reducing lipid levels

Human Genome Sciences and GlaxoSmithKline to present Phase 3 trial results of BENLYSTA

FDA approves Boehringer Ingelheim's MICARDIS for the reduction of risk of heart attack

Unlike obesity, overweight does not increase mortality rate

Inclusion of vitamin D values in National Nutrient Database

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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