Cytochrome P450 News and Research

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Model simulations show no need for DEX dose adjustments in COVID-19 patients with liver disease

A recent study sed PBPK modeling to demonstrate the use of DEX PKs for the treatment of COVID-19 in patients with liver impairment.

17 Nov 2021

Lipids, COVID-19, and host immunity

A new study from a team of researchers at the University of Pennsylvania examines the role played by lipids in this disease.

10 Oct 2021

Cyperus rotundus medicinal plant shows promise for novel COVID-19 therapeutics

Cyperus rotundus is a plant with a history as herbal medicine, containing many chemical substances frequently found to be drug-like in character: flavonoids, terpenoids, and the like. Compounds sourced from the plant have demonstrated some inhibitory activity against HIV by modulation of the CYP3A4 enzyme, and thus in a drug lead discovery effort, Kumar et al. (July 2021) computationally screened these natural compounds against MPRO in a paper recently published to Computers in Biology and Medicine.

9 Jun 2021

New method could be used to develop more effective treatments for cancer, metabolic disorders

Researchers from the University of Copenhagen have developed a new method that makes it possible to control human hormones and metabolism.

28 Apr 2021

Study reveals molecular mechanisms of drug resistance in Mycobacterium tuberculosis

A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way in which Mycobacterium tuberculosis survives in iron-deficient conditions by utilizing rubredoxin B, a protein from a rubredoxin family that play an important role in adaptation to changing environmental conditions.

9 Apr 2021

Scientists grow small intestinal cells from human-induced pluripotent stem cells

A team of scientists from Japan have found success in growing small intestinal cells, akin to those found in the human body, from human-induced pluripotent stem cells.

8 Feb 2021

SARS-CoV-2 infection shown to reduce the expression of vitamin D pathway components

A recent computational study from India implicated a dysregulated vitamin D pathway in the pathobiology of the infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and opened the door for experimental validation of these observations.

23 Dec 2020

Lopinavir-ritonavir does not suppress SARS-CoV-2 activity in vitro

Among them is the combination of lopinavir and ritonavir, which have been in use in an attempt to reduce the severity of the disease. However, a new South Korean study published on the preprint server bioRxiv in September 2020 shows that this combination is ineffective against the virus.

20 Sep 2020

Common antioxidant enzyme catalase as COVID-19 treatment

A new paper by researchers from the USA and China and published on the preprint server bioRxiv in July 2020 discusses a new drug based on the catalase enzyme, which could play a vital part in reducing the inflammation associated with progressive and severe COVID-19 disease.

17 Jul 2020

Concentration of lopinavir and hydroxychloroquine not sufficient to fight novel coronavirus

Lopinavir is a drug against HIV, hydroxychloroquine is used to treat malaria and rheumatism. Until recently, both drugs were regarded as potential agents in the fight against the coronavirus SARS-CoV-2.

11 Jul 2020

Genomic sequencing to provide precision medicine for aromatase deficiency

An international team of scientists from Switzerland Spain, has studied the genetic basis of aromatase deficiency, a rare metabolic disorder that prevents the production of estrogens in humans, according to new research in JCEM.

30 Jun 2020

Popular painkiller may have more significant effects on the liver than expected

The popular painkiller ibuprofen may have more significant effects on the liver than previously thought, according to new research from the University of California, Davis.

11 Mar 2020

How cannabis interacts with medications

A new practice guideline published in the journal CMAJ in February 2020 describes five types of drug interactions possible with the use of cannabis. Cannabis is a plant-derived drug containing the psychoactive ingredient delta-9-tetrahydrocannabinol (THC) and non-psychoactive cannabidiol (CBD). These cannabinoids are broken down by the liver enzymes cytochrome P450 C(YP)34A, and CYP2CC9.

2 Mar 2020

People with drug-induced liver damage could continue taking life-saving medications

When you ingest a drug--whether over-the-counter Tylenol or medication prescribed by a doctor--your liver is your body's first responder.

28 Feb 2020

Swansea University drug resistance research highlighted in two prestigious journals

Swansea University research into the threat posed by antifungal drug resistance has been highlighted in two prestigious international journals.

14 Feb 2020

Alarming link between marijuana and increased heart risk

Marijuana use is rising steadily across the US as more and more states enact laws making it a legal recreational and medicinal agent. However, a new study underlines the fact that this is, in fact, playing with an unknown substance, which may cause serious bodily harm. The review article, published in the Journal of the American College of Cardiology, shows that more than 2 million adults who currently have heart or vascular disease gave a history of being currently on marijuana products, or having used them in the past.

20 Jan 2020

Doctors should warn cardiology patients about the risk of marijuana use, say researchers

A team led by investigators at Brigham and Women's Hospital has stated that cardiology patients should be warned and counseled about the potential risks of using marijuana until further evidence is available.

20 Jan 2020

Addictions and drug interactions common among patients not disclosing their medication history

Some patients skip telling their doctors about the drugs and medications they are consuming. A new study shows that these patients are at a greater risk of unpleasant and sometimes dangerous drug-drug interactions as well as addictions. The study was published in the latest issue of The Journal of the American Osteopathic Association. The study is titled, “Role of opioid-involved drug interactions in chronic pain management”.

11 Dec 2019

FDA expands approval of cystic fibrosis treatment to include pediatric patients as young as 6 years old

The U.S. Food and Drug Administration today expanded the indication for Symdeko (a combination of tezacaftor/ivacaftor) tablets for treatment of pediatric patients ages 6 years and older with cystic fibrosis who have certain genetic mutations.

22 Jun 2019

New research helps provide better understanding of megaviruses

Swansea University has played a key role in transatlantic research to develop a greater understanding of megaviruses and their potential to cause life-threatening illnesses.

7 Jun 2019