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Differences in lifestyle, tumor genetics linked to head and neck cancer in African Americans

Why are African Americans more likely than Caucasians to be not only diagnosed with head and neck cancer, but also die from the disease? While the answer isn't a simple one, differences in lifestyle, access to care and tumor genetics may, in part, be to blame, according to a new study from Henry Ford Hospital.

15 Sep 2011

Inovio achieves best-in-class immune responses in PENNVAX-B HIV vaccine Phase I study

Inovio Pharmaceuticals, Inc., a leader in the development of synthetic immunogens against cancers and infectious diseases, announced today that it has achieved best-in-class immune responses in a Phase I clinical study of PENNVAX-B, its product for the prevention of the HIV sub-type prevalent in the US and Europe.

14 Sep 2011

ZIOPHARM initiates ZIN ATI-001 Phase 1 clinical study in advanced melanoma

ZIOPHARM Oncology, Inc. today announced that the first patient has been dosed in a Phase 1 clinical study of ZIN ATI-001, a novel DNA-based therapeutic candidate, in patients with advanced melanoma.

30 Aug 2011

Researchers discover expression of IL-37 that protects mice from colitis

Inflammatory bowel disease (IBD), which affects more than 1 million patients in North America, results from an uncontrolled immune response triggered by environmental factors, such as bacteria, in people genetically predisposed to the disorder. Ulcerative colitis, or inflammation of the lining of the colon, is one such condition.

24 Aug 2011

Quanterix's ELISA precisely measures low abundance cytokines in Crohn's disease

Quanterix Corporation, a company enabling a new generation of molecular diagnostic tests based on its revolutionary Single Molecule Array technology, today announced results of a pilot study to measure biomarkers of inflammation from patients with Crohn's disease.

20 Aug 2011

CEL-SCI receives Chinese patent for Multikine cancer drug

CEL-SCI Corporation today announced that the Chinese patent office has issued a key patent covering CEL-SCI's investigational cancer drug, Multikine.

18 Aug 2011

Scientists identify potential target that could combat allergies of early childhood

A pandemic of ailments called the "allergic march" -- the gradual acquisition of overlapping allergic diseases that commonly begins in early childhood -- has frustrated both parents and physicians. For the last three decades, an explosion of eczema, food allergies, hay fever, and asthma have afflicted children in the United States, the European Union, and many other countries.

16 Aug 2011

Researchers identify novel sensory pathway that modulates pro-inflammatory cells

New research led by Derya Unutmaz, MD associate professor, the Departments of Pathology, Medicine, and Microbiology at NYU School of Medicine and Mark Sundrud, PhD, of Tempero Pharmaceuticals, Inc., has identified a novel sensory pathway that modulates the potency of Th17 cell responses.

11 Aug 2011

A diet of flaxseed shows protective effects against radiation in mice

Flax has been part of human history for well over 30,000 years, used for weaving cloth, feeding people and animals, and even making paint. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania have discovered that it might have a new use for the 21st century: protecting healthy tissues and organs from the harmful effects of radiation.

10 Aug 2011

Engineered T cells can eradicate deadly human ovarian cancer in immune-deficient mice

In a recent issue of Cancer Research, Daniel J. Powell, Jr., PhD, a research assistant professor of Pathology and Laboratory Medicine and Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania, showed for the first time that engineered human T cells can eradicate deadly human ovarian cancer in immune-deficient mice.

9 Aug 2011

Key protein discoveries could lead to new lung repair therapies for children, adults

A team at The Saban Research Institute of Children's Hospital Los Angeles has made crucial discoveries about the role of key proteins in wound healing in the tiny air sacs in the lungs known as "alveoli" that could lead to new therapies for children and adults.

5 Aug 2011

Femta files IND with FDA for FM101 monoclonal antibody against RA

Femta Pharmaceuticals announced today that it has submitted an Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) to initiate a clinical development program for FM101, a high-affinity, humanized monoclonal antibody against Interleukin-6 (IL-6), in patients with rheumatoid arthritis (RA).

1 Aug 2011

Oral chicken interferon-alpha may significantly reduce influenza infection

Avian influenza virus is a threat to the commercial chicken industry and, with its recent rapid spread across China, has also shown the ability for transmission from chickens to humans and other mammals.

29 Jul 2011

Cigarette smoke exposure alters airway tissue in people with COPD

Cigarette smoke exposure fundamentally alters airway tissue from people with chronic obstructive pulmonary disease (COPD) at the cellular level, laying the groundwork for airway thickening and even precipitating precancerous changes in cell proliferation that may be self-perpetuating long after cigarette smoke exposure ends, according to Australian researchers.

28 Jul 2011

New details about how dendritic cells regulate fate of naive T cells

St. Jude Children's Research Hospital scientists show that the molecule serves as a bridge between the two arms of the immune system that provides a new mechanism guiding T cell differentiation.

25 Jul 2011

Fish oil consumption helps reduce inflammation, anxiety in healthy young people

A new study gauging the impact of consuming more fish oil showed a marked reduction both in inflammation and, surprisingly, in anxiety among a cohort of healthy young people.

14 Jul 2011

Macrogenics' Protege Phase 3 clinical study of teplizumab in type 1 diabetes published in The Lancet

MacroGenics, Inc., a privately held biotechnology company that develops immunotherapeutics to treat autoimmune disorders, cancer and infectious diseases, announced the publication in The Lancet of results from Protege, a Phase 3 clinical study of teplizumab in type 1 diabetes.

29 Jun 2011

Turning back the clock on aging stem cells to make better bone

Researchers want to turn back the clock on aging stem cells so they'll make better bone.

10 Jun 2011

Blinatumomab phase 2 trial results on acute lymphoblastic leukemia to be presented at EHA 2011

Data to be presented tomorrow at the 16th Annual Meeting of the European Hematology Association (EHA) in London, UK, show that Micromet's blinatumomab produced a high complete remission rate in adult patients with acute lymphoblastic leukemia (ALL) who had relapsed following treatment with standard therapy.

10 Jun 2011

FDA accepts ZIOPHARM's IND for ZIN ATI-001 to treat melanoma

ZIOPHARM Oncology, Inc., a drug development company employing small molecule and synthetic biology approaches to cancer therapy, announced today that the U.S. Food & Drug Administration has accepted the Company's investigational new drug application to begin clinical study of ZIN ATI-001, a novel DNA-based therapeutic candidate also known as Ad-RTS-IL-12 + AL, in oncology.

10 Jun 2011

Cytokine News and Research

Differences in lifestyle, tumor genetics linked to head and neck cancer in African Americans

Inovio achieves best-in-class immune responses in PENNVAX-B HIV vaccine Phase I study

ZIOPHARM initiates ZIN ATI-001 Phase 1 clinical study in advanced melanoma

Researchers discover expression of IL-37 that protects mice from colitis

Quanterix's ELISA precisely measures low abundance cytokines in Crohn's disease

CEL-SCI receives Chinese patent for Multikine cancer drug

Scientists identify potential target that could combat allergies of early childhood

Researchers identify novel sensory pathway that modulates pro-inflammatory cells

A diet of flaxseed shows protective effects against radiation in mice

Engineered T cells can eradicate deadly human ovarian cancer in immune-deficient mice

Key protein discoveries could lead to new lung repair therapies for children, adults

Femta files IND with FDA for FM101 monoclonal antibody against RA

Oral chicken interferon-alpha may significantly reduce influenza infection

Cigarette smoke exposure alters airway tissue in people with COPD

New details about how dendritic cells regulate fate of naive T cells

Fish oil consumption helps reduce inflammation, anxiety in healthy young people

Macrogenics' Protege Phase 3 clinical study of teplizumab in type 1 diabetes published in The Lancet

Turning back the clock on aging stem cells to make better bone

Blinatumomab phase 2 trial results on acute lymphoblastic leukemia to be presented at EHA 2011

FDA accepts ZIOPHARM's IND for ZIN ATI-001 to treat melanoma

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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