DNA Damage News and Research

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Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Why does the risk of heart disease go up as we age? Known risk factors such as hypertension or high cholesterol don't explain all cases.

12 Aug 2022

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

DNA damage caused by factors such as ultraviolet radiation affect nearly three-quarters of all stem cell lines derived from human skin cells, say Cambridge researchers, who argue that whole genome sequencing is essential for confirming if cell lines are usable.

11 Aug 2022

Scientists discover new target for treatment of premature aging disorders

A stretch of DNA that hops around the human genome plays a role in premature aging disorders, scientists at the Salk Institute and King Abdullah University of Science and Technology in Saudi Arabia have discovered.

10 Aug 2022

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

In a study recently published in Cancer Research, a journal of the American Association for Cancer Research, a team of researchers led by C. Patrick Reynolds, M.D., Ph.D., director for the Texas Tech University Health Sciences Center School of Medicine Cancer Center, sought to expand upon his lab's previous research that showed ALT tumors identified by a biomarker known as C-circles share a common biology that confers vulnerabilities to be exploited for cancer therapy.

10 Aug 2022

IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

CRISPR/Cas9 is a commonly used, very precise, gene editing technique whose development, by Jennifer A. Doudna and Emmanuelle Charpentier, was recognised with the 2020 Nobel Prize in Chemistry. Commonly known as "genetic scissors", CRISPR allows the introduction of the desired DNA sequence into (virtually) any spot of the genome, thus modifying or inactivating a gene. This technique is widely used in biomedical research and some CRISPR-based therapies are in clinical trials for the treatment of human blood disorders, some types of cancer and HIV, among other conditions.

10 Aug 2022

The eyes of mutant zebrafish help understand the role of a protein in preventing cell death

Around 15 years ago, a group of researchers discovered mutant zebrafish. The eyes of these zebrafish did not develop correctly, resulting in them being significantly smaller than the eyes of wild zebrafish.

9 Aug 2022

Research progress on the three-dimensional interaction between virus and host genome

A recent study reviewed the current progress on 3D interactions between host and viral genomes.

8 Aug 2022

The aging human brain

Researchers describe alterations at the molecular and cellular levels that underly brain aging in otherwise healthy elderly adults.

3 Aug 2022

NUS study provides evidence of the cytotoxic effect of black cardamom on lung cancer cells

The main challenges associated with existing lung cancer drugs are severe side effects and drug resistance. There is hence a constant need to explore new molecules for improving the survival rate and quality of life of lung cancer patients.

1 Aug 2022

Nanoparticles' toxic effects on macrophages

Researchers summarize the toxic effects of nanoparticles on macrophages in vitro.

31 Jul 2022

Study determines the reason behind the failure of IVF embryos

In humans, a fertilized egg is no guarantee of reproductive success. Most embryos stop developing and perish within days of fertilization, usually because they have an abnormal number of chromosomes. Now, researchers at Columbia University Vagelos College of Physicians and Surgeons have found that most of these mistakes are due to spontaneous errors in DNA replication in the earliest phase of cell division.

20 Jul 2022

Non-coding 'junk' DNA could potentially contribute to the development of cancer

Scientists have found that non-coding 'junk' DNA, far from being harmless and inert, could potentially contribute to the development of cancer.

19 Jul 2022

The known and proposed interactions of SARS-CoV and SARS-CoV-2 with DNA damage response pathways

Researchers reviewed the consequences of infection with sSARS-CoVs on the host DNA damage response.

19 Jul 2022

Research describes one of the ways the SARS-CoV-2 virus recruits cells to replicate

An article published in the journal Frontiers in Cellular and Infection Microbiology reports a study by researchers at the State University of Campinas (UNICAMP) and the University of São Paulo (USP) in Brazil showing how a human protein interacts with a SARS-CoV-2 protein, and describing one of the ways the virus that causes COVID-19 recruits cells to replicate.

18 Jul 2022

Bacterial infections cause sperm dysfunction via their outer membrane vesicles

A new study discusses the impact of Escherichia coli (E. coli) infection on sperm parameters.

13 Jul 2022

Constant activation of p53 in hepatocytes of CLD patients could promote the development of liver cancer

p53 is one of the most important proteins in cancer biology. Often referred to as a "guardian of the genome," p53 becomes activated in response to various cellular stressors like DNA damage.

12 Jul 2022

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

The Damon Runyon Cancer Research Foundation has named five new Damon Runyon Clinical Investigators.

6 Jul 2022

Immune response triggered by COVID-19 damages the brain's blood vessels to cause neurological complications

A study from the National Institutes of Health describes the immune response triggered by COVID-19 infection that damages the brain's blood vessels and may lead to short- and long-term neurological symptoms.

5 Jul 2022

Human gingival epithelial cells become damaged by cannabis smoke condensate

In a new study, scientists evaluated the effect of cannabis smoke condensate (CSC) on the gingival epithelial cells.

5 Jul 2022

Study uncovers new gene that increases Alzheimer's disease risk in women

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S. Scientists have discovered some genetic variants that increase the risk for developing Alzheimer's; the most well-known of these for people over the age of 65 is the APOE ε4 allele.

30 Jun 2022

DNA Damage News and Research

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

Scientists discover new target for treatment of premature aging disorders

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

The eyes of mutant zebrafish help understand the role of a protein in preventing cell death

Research progress on the three-dimensional interaction between virus and host genome

The aging human brain

NUS study provides evidence of the cytotoxic effect of black cardamom on lung cancer cells

Nanoparticles' toxic effects on macrophages

Study determines the reason behind the failure of IVF embryos

Non-coding 'junk' DNA could potentially contribute to the development of cancer

The known and proposed interactions of SARS-CoV and SARS-CoV-2 with DNA damage response pathways

Research describes one of the ways the SARS-CoV-2 virus recruits cells to replicate

Bacterial infections cause sperm dysfunction via their outer membrane vesicles

Constant activation of p53 in hepatocytes of CLD patients could promote the development of liver cancer

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

Immune response triggered by COVID-19 damages the brain's blood vessels to cause neurological complications

Human gingival epithelial cells become damaged by cannabis smoke condensate

Study uncovers new gene that increases Alzheimer's disease risk in women

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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