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Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

A Phase 2 trial led by City of Hope, a world-renowned research and treatment center for cancer and diabetes, suggests that adding the novel ataxia telangiectasia and Rad3-related (ATR) inhibitor drug berzosertib to standard-of-care chemotherapy for patients with metastatic urothelial cancer does not extend progression-free survival.

27 Aug 2021

Study offers hope for an era of safer chemotherapy in breast cancer

Breast cancer is the deadliest and most common type of cancer in women. The treatment options often require administration of anti-cancer drugs in high doses, as the cells develop resistance towards chemotherapy, leading to painful side effects in patients.

23 Aug 2021

Researchers report potential of a berry-producing vine against lung cancer in mice

Lung cancer is known to be the most fatal form of cancer. Chemicals like 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) found in tobacco are usually the main culprits behind smoking-related lung cancer causing cancer biologists to actively explore targeted treatments.

17 Aug 2021

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

In a recent study published in Cancer Research, researchers from Fels Cancer Institute for Personalized Medicine at the Lewis Katz School of Medicine at Temple University and Fox Chase Cancer Center identified specific leukemia gene mutations and the mechanisms by which they regulate DNA repair and respond to PARP inhibitors.

13 Aug 2021

PTEN nuclear translocation plays a key role in neuronal injury following hypoxia-ischemia

Aging-US published "PTEN nuclear translocation enhances neuronal injury after hypoxia-ischemia via modulation of the nuclear factor-κB signaling pathway" which reported that this study was designed to investigate phosphatase and tensin homolog nuclear translocation and its possible role in rat cortical neuronal damage following oxygen-glucose deprivation in vitro.

9 Aug 2021

New study offers insight into how high-risk form of blood cancer can develop in children

In some children with acute myeloid leukemia, cancer cells have the same amount of DNA changes as healthy blood stem cells.

6 Aug 2021

Melanoma mutations result from a chemical conversion in DNA fueled by sunlight, study reports

The mutations that give rise to melanoma result from a chemical conversion in DNA fueled by sunlight -; not just a DNA copying error as previously believed, reports a study by Van Andel Institute scientists published today in Science Advances.

30 Jul 2021

SARS-CoV-2 reprograms host chromatic network to induce immune dysfunction

A recent study conducted at the University of Texas Science Center, Houston, in the USA, has revealed that upon infection, SARS-CoV-2 alters the host chromatin architecture to suppress antiviral interferon-responsive genes and augment inflammatory genes. The study is currently available on the bioRxiv* preprint server.

22 Jul 2021

Researchers determine the structure of nanomachine essential for functioning of mTOR

The principle that form follows function does not only apply to design and architecture. It also applies to biology

8 Jul 2021

Skin pigmentation mechanism confers major protection against UV-related cancers

A skin pigmentation mechanism that can darken the color of human skin as a natural defense against ultraviolet (UV)-associated cancers has been discovered by scientists at Massachusetts General Hospital (MGH).

7 Jul 2021

EORTC partners with Pierre Fabre to support patients with stage 2 melanoma

European Organisation for Research and Treatment of Cancer (EORTC) and Pierre Fabre today announced a strategic partnership in support of patients with resected Stage 2 BRAF-mutant melanoma.

29 Jun 2021

Increasing novel lncRNA in cardiomyocytes can inhibit the progression of heart failure

A research collaboration based in Kumamoto University (Japan) has identified a novel lncRNA, Caren, that is abundantly expressed in cardiomyocytes.

23 Jun 2021

Unrepaired DNA damage can increase the speed of aging, study suggests

Every day, our bodies face a bombardment of UV rays, ozone, cigarette smoke, industrial chemicals and other hazards.

21 Jun 2021

Yeast cell machinery seamlessly 'reads' the unnatural ingredients in the genetic recipe

If the genome is the recipe of life, base pairs are the individual ingredients listed. These chemical structures form DNA, and every living organism on Earth has just four. The specific arrangements of these four base pairs -- A, T, C, G -- make us who and what we are.

18 Jun 2021

Adding immune oncology drug to chemotherapy improves response in subset of breast cancer patients

In a new study by researchers at Yale Cancer Center, combining the immunotherapy drug durvalumab and PARP-inhibitor olaparib with chemotherapy improved response to treatment for women with high-risk, HER2-negative breast cancer, including a subset of estrogen receptor positive cancers.

18 Jun 2021

Novel drug class shows potential to treat cancer patients with faulty BRCA genes

Scientists have identified a new class of targeted cancer drugs that offer the potential to treat patients whose tumors have faulty copies of the BRCA cancer genes.

17 Jun 2021

Repressing a protein that facilitates DNA repair to potentiate chemotherapy

Chemotherapy kills tumor cells by causing damage to them. One of the most effective ways of causing damage is to prevent the two DNA strands from separating so that the cellular machinery cannot read the instructions written in the genes.

15 Jun 2021

WHO: Effective action needed to protect the health of children from toxic e-waste

Effective and binding action is urgently required to protect the millions of children, adolescents and expectant mothers worldwide whose health is jeopardized by the informal processing of discarded electrical or electronic devices according to a new ground-breaking report from the World Health Organization: Children and Digital Dumpsites.

15 Jun 2021

Study may offer an unexpected pathway for targeted treatment of brain tumors

In a new study led by Yale Cancer Center, researchers show the nucleoside transporter ENT2 may offer an unexpected path to circumventing the blood-brain barrier (BBB) and enabling targeted treatment of brain tumors with a cell-penetrating anti-DNA autoantibody.

15 Jun 2021

What makes the elderly more susceptible to SARS-CoV-2 infection?

Why is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19 (coronavirus disease 2019), biased towards infecting the aged population? A recently published study by Italian scientists linked aging, DNA damage, telomere shortening, and increased levels of angiotensin-converting enzyme 2 (ACE2) to this relationship.

13 Jun 2021

DNA Damage News and Research

Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

Study offers hope for an era of safer chemotherapy in breast cancer

Researchers report potential of a berry-producing vine against lung cancer in mice

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

PTEN nuclear translocation plays a key role in neuronal injury following hypoxia-ischemia

New study offers insight into how high-risk form of blood cancer can develop in children

Melanoma mutations result from a chemical conversion in DNA fueled by sunlight, study reports

SARS-CoV-2 reprograms host chromatic network to induce immune dysfunction

Researchers determine the structure of nanomachine essential for functioning of mTOR

Skin pigmentation mechanism confers major protection against UV-related cancers

EORTC partners with Pierre Fabre to support patients with stage 2 melanoma

Increasing novel lncRNA in cardiomyocytes can inhibit the progression of heart failure

Unrepaired DNA damage can increase the speed of aging, study suggests

Yeast cell machinery seamlessly 'reads' the unnatural ingredients in the genetic recipe

Adding immune oncology drug to chemotherapy improves response in subset of breast cancer patients

Novel drug class shows potential to treat cancer patients with faulty BRCA genes

Repressing a protein that facilitates DNA repair to potentiate chemotherapy

WHO: Effective action needed to protect the health of children from toxic e-waste

Study may offer an unexpected pathway for targeted treatment of brain tumors

What makes the elderly more susceptible to SARS-CoV-2 infection?

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Expanding research and clinical options for children with cancer

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