Dengue Fever News and Research

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Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash.

Scientists determine structure of endomannosidase enzyme

Scientists have determined the structure of the enzyme endomannosidase, significantly advancing our understanding of how a group of devastating human viruses including HIV and Hepatitis C hijack human enzymes to reproduce and cause disease.

4 Jan 2012

BBC News Magazine examines antiviral drug research

BBC News Magazine examines an antiviral drug called Draco, developed by Todd Rider, a research scientist at the Massachusetts Institute of Technology, "which has proven successful against all 15 viruses to which it has been applied in lab trials with human tissue and mice," including "the common cold, H1N1 or swine flu, a polio virus, dengue fever, and the notorious and fatal Ebola virus."

23 Dec 2011

Experimental sublingual vaccine shows promise against influenza infection

Scientists from the International Vaccine Institute (IVI) have discovered that an antigen common to most influenza viruses, and commonly referred to as matrix protein 2 (M2), when administered under the tongue could protect mice against experimental infection caused by various influenza viruses, including the highly pathogenic avian H5 virus and the pandemic H1 ("swine flu") virus.

9 Dec 2011

Inviragen presents DENVax Phase 1 trial results on dengue at ASTMH annual meeting

Inviragen, Inc. presented results of the Phase 1 clinical trial of DENVax conducted in Colombia at the annual American Society of Tropical Medicine and Hygiene (ASTMH) meeting today.

8 Dec 2011

Fatal snakebites 'vastly underreported,' researchers report at annual ASTMH meeting

"Fatal snakebites worldwide have been vastly underreported because many die before seeking or reaching medical care, researchers" from the Biodiversity and Climate Research Centre in Frankfurt, Germany, reported on Monday at the American Society of Tropical Medicine and Hygiene's (ASTMH) annual meeting, UPI.com writes.

8 Dec 2011

NanoViricides submits pre-IND Meeting Request for FluCide to FDA

NanoViricides, Inc. announced today that it has submitted a pre-IND Meeting Request to the US FDA. The Company has requested an initial meeting with the US FDA to review the Company's proposed strategy and plan for conducting safety/toxicology studies and human clinical trials required for approval of its anti-influenza clinical drug candidate, FluCide™ (i.e. NV-INF-1).

5 Dec 2011

Inviragen commences DENVax Phase 2 trial for dengue

Inviragen, Inc. today announced the initiation of a Phase 2, randomized, double-blind, placebo-controlled study of DENVax, the Company's investigational dengue vaccine.

28 Nov 2011

Suppressing mosquitoes - the only way of controlling dengue

There is no vaccine against dengue, an emerging tropical disease regularly also hitting tourists, so the only way of controlling it is by suppressing the mosquitoes transmitting the disease.

28 Nov 2011

Cambodia set to distribute more than 2.5M mosquito nets by end of year

"Millions of Cambodians are set to receive insecticide-treated mosquito nets as part of a government-led effort to mitigate the risk of malaria and dengue fever," IRIN reports.

14 Nov 2011

IVI receives WHO prequalification for new oral cholera vaccine

Shanchol-, a new oral cholera vaccine developed through the International Vaccine Institute (IVI), an international organization established by the United Nations and based in Seoul, recently received prequalification from the World Health Organization.

13 Nov 2011

Annual European CDC report says infectious diseases, drug resistance are concerns

"Europe's health is suffering, with around 80,000 cases of tuberculosis infection a year and serious problems with measles, HIV and threats from 'superbug' infections, an annual health report" from the European Centre for Disease Prevention and Control (ECDC) said Thursday, Reuters reports.

11 Nov 2011

U.N., aid groups appeal for additional funding, supplies for Pakistan flood victims

The U.N. and several other international aid groups, including Oxfam, Save the Children, Care and ACTED, on Wednesday "warn[ed] they are running short of money and supplies to help millions of people affected by floods in Pakistan," the Associated Press reports.

10 Nov 2011

GM mosquitoes show promise in tackling insect-borne diseases, study shows; some concerned over possible unintended consequences

"Genetically modified mosquitoes could prove effective in tackling dengue fever and other insect-borne diseases," according to the results of a study by a U.K.-based scientific team published in the journal Nature Biotechnology on Sunday, BBC News reports.

2 Nov 2011

Wolbachia study reveals novel approaches to control insects transmitting deadly diseases

Researchers at Boston University have made discoveries that provide the foundation towards novel approaches to control insects that transmit deadly diseases such as dengue fever and malaria through their study of the Wolbachia bacteria.

21 Oct 2011

Two genetic variants associated with increased susceptibility to severe dengue

Researchers in South East Asia have identified two genetic variants associated with increased susceptibility to severe dengue. The study, funded by the Wellcome Trust and the Agency for Science, Technology, and Research, Singapore, offers clues to how the body responds to dengue infection.

18 Oct 2011

Four companies receive NIAID contracts to develop broad-spectrum therapeutics

Four companies are to develop broad-spectrum therapeutics-antibiotics, antivirals and an antitoxin-to prevent or treat diseases caused by multiple types of bacteria or viruses, under contracts awarded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

14 Oct 2011

Pakistan facing dengue outbreak, humanitarian aid shortages for flood victims

"More than 12,000 have been infected and 125 people have died over the past two months in Pakistan after coming down with dengue fever, a health department spokesman said Friday," CNN reports.

4 Oct 2011

Dengue fever outbreak overwhelms northeastern Kenyan town; WHO sends essential drugs

"An outbreak of dengue fever in Mandera, northeastern Kenya, is spreading fast, with at least 5,000 people infected within weeks, due to limited health facilities, a shortage of medical personnel and poor sanitation, officials told IRIN."

1 Oct 2011

Increased focus on vaccine for dengue fever is critical to curb spread of disease

In this GlobalPost opinion piece, Zulfiqar Bhutta, Husein Laljee Dewraj professor and head of the Division of Maternal and Child Health at the Aga Khan University Medical Center in Karachi, Pakistan, and Ciro de Quadros, executive vice president of the Sabin Vaccine Institute and former director of the Division of Vaccines and Immunization at PAHO, examine the need for a dengue fever vaccine as Pakistan struggles to curb an outbreak of the disease that to date has killed 60 people and has infected more than 8,000.

30 Sep 2011

Pakistan officials ask for international assistance as dengue fever outbreak overwhelms local resources

BBC News reports on a continuing outbreak of dengue fever in Pakistan's Punjab province, where "more than 8,000 cases of dengue fever have been reported in the province so far -- 7,000 in Lahore alone -- and the count continues to rise," according to the Punjab health department. According to the news service, "Doctors say more than 30 people have died of the fever so far" in the province, and "health officials estimate that more than 7,000 people are being tested daily for the virus -- 300 to 400 test positive each day".

27 Sep 2011