Dexamethasone News and Research

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‘Foreign body reaction’ to implants can be reduced by incorporating drug into silicone coating

Long-term use of implantable electronic medical devices – such as pacemakers and cochlear implants – is hampered by the body's reaction to foreign bodies.

14 Mar 2022

The impact of PLEX on the survival of patients with severe COVID-19 and the effect on the cytokine release syndrome

Researchers evaluated the survival benefit conferred by PLEX in patients with severe COVID-19 and cytokine-storm syndrome.

14 Mar 2022

Biotech spinout receives $42 million to develop 'future-proofed' coronavirus vaccines

Prime Minister Boris Johnson today announced that DIOSynVax, a biotech spinout of the University of Cambridge, will receive $42million to develop a vaccine candidate that could provide protection against both existing and future variants of SARS-CoV-2 - the virus that causes COVID-19 - as well as other major coronaviruses, including those that cause SARS and MERS.

8 Mar 2022

Clinical outcomes of regdanvimab usage in patients with mild to moderate COVID-19

Researchers evaluated the effectiveness of regdanvimab on clinical outcomes in patients with mild to moderate COVID-19.

7 Mar 2022

Adenosine receptor agonists provide therapeutic target in mouse SARS-CoV-2 infection

A new study describes the efficacy of adenosine receptor agonists in the treatment of SARS-CoV-2 infection.

2 Mar 2022

Government invests £260 million to support health research and life sciences manufacturing

Patients across the country are set to benefit from cutting-edge medical advances and treatments as the government invests £260 million today (Wednesday 2 March) to support research and development, as well as the manufacturing of new drugs, devices and diagnostics.

2 Mar 2022

Mechanism of fatty-acid coupled adaptive immunity in SARS-CoV-2 revealed

A new study explains how SARS-CoV-2 adapts its immunogenicity to the immune response of the host.

20 Feb 2022

Cardiovascular markers for predicting clinical outcomes in SARS-CoV-2 infection

In a recent study posted to the medRxiv* preprint server, an interdisciplinary team of researchers from Toronto, Canada, characterized the markers of endothelial function and developed micro ribonucleic acid (miRNA) expression atlas in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive and -negative patients admitted to the intensive care unit (ICU).

15 Feb 2022

How SARS-CoV-2 infection progresses throughout the respiratory system

Researchers discuss the progression of SARS-CoV-2 infection throughout the respiratory epithelium.

9 Feb 2022

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

An FDA-approved drug that has been in clinical use for more than 70 years may protect against lung injury and the risk of blood clots in severe COVID-19 and other disorders that cause immune-mediated damage to the lungs, according to a preclinical study from researchers at Weill Cornell Medicine and Cold Spring Harbor Laboratory.

8 Feb 2022

Study uncovers a series of natural products that can inhibit the main protease of SARS-CoV-2

The fight against the COVID-19 pandemic is an international scientific challenge regarding the search for strategies to fight the viral infection and prevent its damaging consequences.

7 Feb 2022

Dexamethasone administration at a late time point could enhance transgene expression

Dexamethasone, a glucocorticoid with anti-inflammatory and immunosuppressive effects, can transiently increase the expression of therapeutic genes delivered using adeno-associated virus (AAV) vectors.

31 Jan 2022

Study identifies drugs that could help combat mortality in patients with COVID-19

Inflammation is a defense mechanism of the body to fight pathogens. However, when it is widespread and excessive, it can aggravate the pathology and even cause death.

31 Jan 2022

The effect of different heterologous vaccination intervention strategies on the winter 2020 COVID-19 wave in the US

Researchers demonstrated the effect of different heterologous vaccine interventions on COVID-19 caseloads, hospitalization, and mortality in the US.

20 Jan 2022

SARS-CoV-2 Omicron infections milder in children compared to Delta

The clinical severity of COVID-19 was found to be lower in children younger than five years of age after the emergence of SARS-CoV-2 Omicron variant.

20 Jan 2022

New findings support the routine use of remdesivir in hospitalized COVID-19 patients

Remdesivir, an antiviral drug used to treat COVID-19, increased the likelihood of clinical improvement in COVID-19 patients on low-flow oxygen or no oxygen, according to a new study authored by the Johns Hopkins University School of Medicine, the Johns Hopkins Bloomberg School of Public Health, HCA Healthcare, and Genospace.

18 Jan 2022

Dexamethasone shown to upregulate innate and adaptive immune responses in COVID-19 acute respiratory distress syndrome patients

In a new study, researchers used per protocol bronchoalveolar lavage fluid (BALF) samples after intubation to evaluate the transcriptomic profiles of the local pulmonary host responses during early-stage severe coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (CARDS), non-COVID-19 ARDS, and sepsis.

17 Jan 2022