Drug Delivery News and Research

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Drug delivery is a term that refers to the delivery of a pharmaceutical compound into the body. Most common methods of delivery include the preferred non-invasive oral (through the mouth), nasal, pneumonial (inhalation), and rectal routes. Much research is now focussing on nanotechnology as a drug delivery method.

Scientists develop nanometer-sized 'cargo ships' to target and destroy tumors

Scientists have developed nanometer-sized 'cargo ships' that can sail throughout the body via the bloodstream without immediate detection from the body's immune radar system and ferry their cargo of anti-cancer drugs and markers into tumors that might otherwise go untreated or undetected.

11 Sep 2008

Alte Biosciences files patent for novel inflammatory bowel disease drugs

Alte Bioscience, Inc., a development stage pharmaceutical company, is pleased to announce the filing of a provisional patent for a new class of drugs that may benefit patients with inflammatory bowel disease.

3 Sep 2008

Normalizing tumor vessels to improve chemotherapy drug delivery

Chemotherapy drugs often never reach the tumors they're intended to treat, and radiation therapy is not always effective, because the blood vessels feeding the tumors are abnormal-"leaky and twisty" in the words of the late Judah Folkman, MD, founder of the Vascular Biology program at Children's Hospital Boston.

25 Aug 2008

Century old rule of chemistry overturned - major implications for drug delivery

A new study by research chemists at the University of Warwick has challenged a century old rule of pharmacology that defined how quickly key chemicals can pass across cell walls. The new observations of the Warwick researchers suggest that the real transport rates could be up to a hundred times slower than predicted by the century old "Overton's Rule". This could have major implications for the development and testing of many future drugs.

25 Aug 2008

Scientists engineer first drug-delivery particles capable of passing through human mucus

Chemical engineers from Johns Hopkins University have broken the "mucus barrier," engineering the first drug-delivery particles capable of passing through human mucus - regarded by many as nearly impenetrable - and carrying medication that could treat a range of diseases. Those conditions include lung cancer, cervical cancer and cystic fibrosis, the research noted in a presentation scheduled for the 236th National Meeting of the American Chemical Society.

20 Aug 2008

Sngle-walled carbon nanotubes used as cancer drug delivery vehicles

The problem with using a shotgun to kill a housefly is that even if you get the pest, you'll likely do a lot of damage to your home in the process. Hence the value of the more surgical flyswatter.

14 Aug 2008

IMPAX sued for patent infringement on generic Ultram ER

IMPAX Laboratories, Inc. today announced Purdue Pharma Products L.P. ("Purdue"), Napp Pharmaceutical Group Ltd. ("Napp"), Biovail Laboratories International, SRL ("Biovail") and Ortho-McNeil, Inc. ("Ortho-McNeil") have filed suit for patent infringement in the United States District Court for the District of Delaware based on the Company's submission of its Abbreviated New Drug Application ("ANDA") for tramadol hydrochloride extended-release tablets (100 mg), generic of Ultram ER, to the Food and Drug Administration.

12 Aug 2008

Corn protein, zein being researched for drug delivery

The key to a better drug delivery method for cancer patients may be growing all across the Midwest, South Dakota State University research suggests.

29 Jul 2008

Ultra-miniature bialy-shaped drug delivery particles

Ultra-miniature bialy-shaped particles - called nanobialys because they resemble tiny versions of the flat, onion-topped rolls popular in New York City - could soon be carrying medicinal compounds through patients' bloodstreams to tumors or atherosclerotic plaques.

29 Jul 2008

Viagra and Levitra ED drugs shown to allow more chemo to reach brain tumors

In a study using laboratory animals, researchers found that medications commonly prescribed for erectile dysfunction opened a mechanism called the blood-brain tumor barrier and increased delivery of cancer-fighting drugs to malignant brain tumors.

28 Jul 2008

Sale of liver disease therapeutic patents

IpAuctions, Inc. will auction the worldwide biotherapeutic patents previously owned by Cell Works Inc., a Maryland-based biotech company, and acquired by CellPoint Diagnostics, Inc., based in Mountain View, Calif. These patents primarily consist of organ-targeted drug delivery systems to combat liver disease.

17 Jul 2008

Researchers step closer to delivering cancer-killing drugs to pediatric brain tumors

An interdisciplinary team of researchers at Washington University in St. Louis, led by Karen L. Wooley, Ph.D., James S. McDonnell Distinguished University Professor in Arts & Sciences, is a step closer to delivering cancer-killing drugs to pediatric brain tumors, similar to the tumor that Senator Ted Kennedy is suffering from.

14 Jul 2008

Nanomaterials key to new strategies for blocking metastasis

A new treatment strategy using targeted nanoparticles to block metastasis with anti-cancer drugs leads to good results using significantly lower doses of toxic chemotherapy, with less collateral damage to surrounding tissue, according to a collaborative team of researchers at the Center of Nanotechnology for Treatment, Understanding, and Monitoring of Cancer at the University of California, San Diego. In designing this system, the investigators, led by David Cheresh, Ph.D., have identified what may become a generic method for using nanotechnology to target metastasis.

9 Jul 2008

Holey nanoparticles create new tumor imaging and therapeutic agent

Using a polymer that has both water-soluble and water-insoluble regions, a team of investigators from the Siteman Center of Cancer Nanotechnology Excellence has created a nanoparticle shaped like a bialy, a close relative of the bagel. Combining this nanoparticle with manganese, a metal that boosts magnetic resonance imaging signals, and an antibody that targets blood vessels, the investigators then created a new type of imaging agent that also has the potential to deliver drugs to tumors.

9 Jul 2008

Nanocantilevers image nanoparticles in cells

Borrowing from a Nobel Prize-winning technique credited with starting the nanotechnology revolution, a team of researchers from Oak Ridge National Laboratory (ORNL) and Northwestern University's Nanomaterials for Cancer Diagnostics and Therapeutics has developed a method for imaging nanoparticles inside of cells.

9 Jul 2008

Smart nanoparticle bomb precisely targets a tumour's blood vessels

A team of researchers in the U.S. have developed a nanoparticle with the ability to precisely deliver cancer-fighting drugs.

9 Jul 2008

Quantum dot nanoparticles can penetrate skin through minor abrasions

Researchers at North Carolina State University have found that quantum dot nanoparticles can penetrate the skin if there is an abrasion, providing insight into potential workplace concerns for healthcare workers or individuals involved in the manufacturing of quantum dots or doing research on potential biomedical applications of the tiny nanoparticles.

2 Jul 2008

Microscopic needles effectively deliver drugs to the eyes

A new technique that effectively delivers drugs to the eyes, using microscopic needles, could offer hope to the millions of patients worldwide suffering from common eye diseases that threaten vision such as glaucoma, macular degeneration and diabetic retinopathy.

30 Jun 2008

Cells have an appetite for micro-doughnuts

Just like humans, liver cells can't resist eating just one or two small doughnuts, say chemists from Scotland in the Royal Society of Chemistry journal Chemical Communications.

24 Jun 2008

Quantum dots stop RNA interference in living cells

More than 15 years ago scientists discovered a way to stop a particular gene in its tracks. The Nobel Prize-winning finding holds tantalizing promise for medical science, but so far it has been difficult to apply the technique, known as RNA interference, in living cells.

24 Jun 2008