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Researchers discover enzyme crucial for DNA repair

Researchers have discovered an enzyme crucial to a type of DNA repair that also causes resistance to a class of cancer drugs most commonly used against ovarian cancer.Scientists from The University of Texas MD Anderson Cancer Center and the Life Sciences Institute of Zhejiang University in China report the discovery of the enzyme and its role in repairing DNA damage called cross-linking in the Science Express advance online publication of Science.

30 Jul 2010

Intra-Cellular Therapies ITI-007 Phase Ib/II clinical trial for schizophrenia meets primary endpoint

Intra-Cellular Therapies, Inc. today announced the results from a Phase Ib/II clinical trial in patients with schizophrenia with ITI-007, the Company's unique, investigational new drug for the treatment of schizophrenia. The trial met its primary endpoint demonstrating that ITI-007 was safe and well-tolerated in patients with stabilized schizophrenia.

30 Jul 2010

New paradigm in TB research may lead to improved vaccination, treatment

Often causing no symptoms in carriers of the disease, worldwide tuberculosis (TB) infects eight to ten million people every year, kills two million, and it is highly contagious as it is spread through coughing and sneezing. "It's a global health disaster waiting to happen, even here in Canada, but this new paradigm in TB research may offer an immediate opportunity to improve vaccination and treatment initiatives," explains Dr. Maziar Divangahi of McGill University and of the Research Institute of the McGill University Health Centre.

30 Jul 2010

Today's Opinions: Haiti's lesson for the U.S.; Ending 'Pay for delay;' Getting the CLASS Act off the ground

In February, a month after Haiti's earthquake, I went down to Port-au-Prince as part of a team that was helping to reactivate cardiac care in the city's public hospital. For several months since, I have observed how the earthquake and its aftermath profoundly changed Haiti's health care system. Over that time, I have come to the unorthodox conclusion that Haiti's tragic experience may show us a way to improve health care in the United States (James Wilentz, 7/28).

30 Jul 2010

Celgene second-quarter non-GAAP total revenue increases 36% to $850 million

Celgene Corporation announced non-GAAP net income of $323.3 million, or non-GAAP diluted earnings per share of $0.69 for the quarter ended June 30, 2010. Non-GAAP net income for the second quarter of 2009 was $216.0 million or non-GAAP diluted earnings per share of $0.46.

29 Jul 2010

EMA recommends orphan medicinal product designation for XOMA 052 in treatment of Behcet's disease

XOMA Ltd., a leader in the discovery and development of therapeutic antibodies, announced that the Committee for Orphan Medical Products of the European Medicines Agency (EMA) has adopted a positive opinion and recommends the granting of orphan medicinal product designation for XOMA 052, an antibody to interleukin-1 beta, for the treatment of Behcet's disease. Positive opinions are submitted to the European Commission for decision and are generally adopted within 30 days of receipt.

29 Jul 2010

First Edition: July 29, 2010

In today's headlines, a new poll shows opposition to health reform declining, and Peter Orszag makes his exit as budget chief -- still pressing lawmakers to make tough budget choices while implementing the new law.

29 Jul 2010

Safeguard Scientifics second-quarter aggregate revenue of partner companies increase 47% to $91.6 million

Safeguard Scientifics, Inc., a holding company that builds value in growth-stage life sciences and technology companies, today announced that aggregate revenue of its partner companies for the three months ended June 30, 2010 was $91.6 million, up 47% from $62.3 million for the same partner companies in the same period of 2009. For the six months ended June 30, 2010, the aggregate partner company revenue was $176.9 million, up 45% from $121.8 million for the same partner companies for the same period of 2009.

29 Jul 2010

FDLI's monograph describes impact of manufacturer's commercial pricing decisions on product pricing

In FDLI's latest monograph, Selling Pharmaceuticals and Biologics to the Federal Government: Federal Supply Schedule and Federal Pricing Requirements, Joy Sturm, Allison Pugsley and Stephen A. Smyers of Hogan Lovells US LLP detail how pharmaceutical and biologics manufacturers can deal effectively with government contracting requirements and price calculation requirements.

29 Jul 2010

Researchers find how angiotensin influences immune system

Researchers in Heidelberg and Stanford have discovered a new signalling pathway of brain cells that explains how widely used antihypertensive drugs could keep inflammation in multiple sclerosis in check. The peptide angiotensin not only raises blood pressure but also activates the immunological messenger substance TGF beta on a previously unknown communication pathway in the brain.

29 Jul 2010

SIR offers five-day course that covers all aspects of acute stroke management

Catheter Lysis of Thromboembolic Stroke -an intensive five-day course offered by the Society of Interventional Radiology Oct. 24-28 in Dallas, Texas-provides interventional radiologists, neurointerventionalists, vascular neurologists and fellows-in-training with the unique educational opportunity to review, observe and discuss all aspects of acute stroke management.

29 Jul 2010

Partnership for Safe Medicines to convene counterfeit drug conference

The Partnership for Safe Medicines (PSM), a group of nonprofit organizations and individuals dedicated to protecting consumers from counterfeit drugs, today announced that it will convene leaders from academia, government and industry in an inaugural conference to be held October 8th at the National Press Club in Washington, D.C.

29 Jul 2010

Nymox provides update on NX-1207 Phase 3 program for benign prostatic hyperplasia

Nymox Pharmaceutical Corporation provided an update today on the Company's Phase 3 program for NX-1207, Nymox's investigational drug for benign prostatic hyperplasia (BPH). The Safety Monitoring Committee meeting of July 22, 2010 for the Phase 3 U.S. pivotal trials of NX-1207 was favorable and indicated no significant safety concerns for the trials to date. Patient recruitment and trial activities for pivotal U.S. studies NX02-0017 and NX02-0018 are proceeding at over 70 well-known urology investigative sites throughout the U.S.

29 Jul 2010

Researchers unveil mechanism of cholera bacteria to create cell energy

Researchers have found that an enzyme in the bacteria that causes cholera uses a previously unknown mechanism in providing the bacteria with energy. Because the enzyme is not found in most other organisms, including humans, the finding offers insights into how drugs might be created to kill the bacteria without harming humans.

29 Jul 2010

Scientists identify new targets to develop treatment for HD

Scientists at the Buck Institute for Age Research have discovered that a particular family of enzymes are involved in the breakdown of proteins that modify the production of toxic fragments that lead to the pathology of Huntington's disease. These enzymes, matrix metalloproteinases, provide new targets for drug therapies for the disease - targets that have already been shown to respond to cancer drugs currently in clinical development.

29 Jul 2010

PFSCM wins Supply Chain Innovation Award, Best Value Supply Chain Provider Award

The Partnership for Supply Chain Management, a partner of the U.S. Agency for International Development under the U.S. President's Emergency Plan for AIDS Relief, has won two prestigious awards for groundbreaking work on PEPFAR's Supply Chain Management System. PFSCM received the Supply Chain Innovation Award and Best Value Supply Chain Provider Award during the European Supply Chain and Logistics Summit held in Prague.

29 Jul 2010

Champions Biotechnology fiscal 2010 operating revenues increase to $4.89 million

Champions Biotechnology, Inc., a company engaged in the development of advanced preclinical platforms and tumor specific data to enhance the value of oncology drugs, today announced its financial results for the fiscal year ended April 30, 2010.

29 Jul 2010

New test to predict suitable treatment for chronic myeloid leukemia patients

Scientists in Japan may have developed a way to accurately predict those patients who will resist treatment with imatinib, which is the standard of care for chronic myeloid leukemia (CML).

29 Jul 2010

FDA Advisory Committee recommends approval of AstraZeneca's ticagrelor for Acute Coronary Syndromes

AstraZeneca today announced that the US Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee recommended the FDA approve AstraZeneca's investigational drug ticagrelor for the reduction of thrombotic events in patients with Acute Coronary Syndromes.

29 Jul 2010

China PharmaHub to close Merger Agreement with World Wide Relics in August 2010

China PharmaHub Corp., a pharmaceutical HUB between Chinese pharmaceutical companies and other pharmaceutical companies located worldwide, announced today that it has entered into a Merger Agreement with World Wide Relics, Inc.. The merger is expected to close in August 2010.

29 Jul 2010

Drugs News and Research

Researchers discover enzyme crucial for DNA repair

Intra-Cellular Therapies ITI-007 Phase Ib/II clinical trial for schizophrenia meets primary endpoint

New paradigm in TB research may lead to improved vaccination, treatment

Today's Opinions: Haiti's lesson for the U.S.; Ending 'Pay for delay;' Getting the CLASS Act off the ground

Celgene second-quarter non-GAAP total revenue increases 36% to $850 million

EMA recommends orphan medicinal product designation for XOMA 052 in treatment of Behcet's disease

First Edition: July 29, 2010

Safeguard Scientifics second-quarter aggregate revenue of partner companies increase 47% to $91.6 million

FDLI's monograph describes impact of manufacturer's commercial pricing decisions on product pricing

Researchers find how angiotensin influences immune system

SIR offers five-day course that covers all aspects of acute stroke management

Partnership for Safe Medicines to convene counterfeit drug conference

Nymox provides update on NX-1207 Phase 3 program for benign prostatic hyperplasia

Researchers unveil mechanism of cholera bacteria to create cell energy

Scientists identify new targets to develop treatment for HD

PFSCM wins Supply Chain Innovation Award, Best Value Supply Chain Provider Award

Champions Biotechnology fiscal 2010 operating revenues increase to $4.89 million

New test to predict suitable treatment for chronic myeloid leukemia patients

FDA Advisory Committee recommends approval of AstraZeneca's ticagrelor for Acute Coronary Syndromes

China PharmaHub to close Merger Agreement with World Wide Relics in August 2010

Drug Discovery - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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