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Biomarkers allow doctors to match therapy to patient

Genetic variations ensure that no two people are exactly alike, nor are their cancers.

13 Apr 2008

The good and bad side of anti-cancer compounds

Compounds known as "HDAC inhibitors" exhibit cancer-killing activities in cultured cells.

11 Apr 2008

Protein sulfatase 2 a possible treatment target for liver cancer recurrence and survival

Deadly and difficult to treat, liver cancer has long resisted attempts by researchers to develop ways to prolong life and prevent recurrence.

11 Apr 2008

Discovery of gene involved in blood stem cell replication, movement

Researchers at the Joslin Diabetes Center have identified a gene that is responsible for the division and movement of marrow-derived, blood-forming stem cells, a finding that could have major implications for the future of bone marrow and blood cell transplantation.

10 Apr 2008

Researchers close in on origins of main ingredient of Alzheimer's plaques

The ability of brain cells to take in substances from their surface is essential to the production of a key ingredient in Alzheimer's brain plaques, neuroscientists at Washington University School of Medicine in St. Louis have learned.

10 Apr 2008

Repeated methamphetamine use causes long-term adaptations in brains of mice

Repeatedly stimulating the mouse brain with methamphetamine depresses important areas of the brain, and those changes can only be undone by re-introducing the drug, according to research at the University of Washington and other institutions.

10 Apr 2008

Methamphetamine use in pregnancy changes learning ability of the offspring

Studies have suggested that infants exposed to methamphetamines while in the womb can suffer irreversible brain damage, although the exact effects of these drugs during pregnancy have been hard to pinpoint due to many other negative behaviors that often occur in meth users.

10 Apr 2008

Methamphetamine addiction mechanism discovered

Researchers have identified, for the first time, long-term changes in the brain circuitry of methamphetamine-addicted mice that can explain why the craving of addiction is so stubborn and long-lived.

10 Apr 2008

Manipulating the immune system like a parasite

One day it may be possible to mimic the tactics used by parasites to trick the body into accepting transplanted tissues or organs.

10 Apr 2008

Researchers identify gene involved in blood stem cell replication, movement

10 Apr 2008

The effect of Raloxifene treatment in postmenopausal women with chronic kidney disease

The osteoporosis drug raloxifene increases bone mineral density and reduces the risk of vertebral fractures among postmenopausal women with mild to moderate chronic kidney disease (CKD), according to a study appearing in the July 2008 issue of the Journal of the American Society Nephrology.

10 Apr 2008

Shutting down schools in the event of a bird flu pandemic could prevent up to one in seven cases

Closing schools in the event of a flu pandemic could slow the spread of the virus and prevent up to one in seven cases, according to a new study published today in the journal Nature.

10 Apr 2008

Surgery and drugs not enough to combat obesity

A review of research examining the effectiveness of different obesity treatments has concluded that no matter what other forms of therapy are offered, changes in lifestyle are imperative if patients want to maximise and maintain their weight loss.

10 Apr 2008

Boffins admit to using drugs to enhance their thinking

A survey of readers of a scientific journal has revealed that one in five use drugs to enhance their thinking.

9 Apr 2008

Over-the-counter sale of child cough medicine for young children to be banned

As from September this year the over-the-counter sale of cough medicines for children under the age of two years old will be banned in Australia.

9 Apr 2008

New technique traces ancestry of disease genes

A team of researchers from Washington University in St. Louis and the Israeli Institute of Technology (Technion) in Haifa has developed a technique to detect the ancestry of disease genes in hybrid, or mixed, human populations.

9 Apr 2008

Stopping a cancer trial early: is it for the benefit of patients or industry?

New research has identified a growing trend for trials of new cancer treatments to be stopped prematurely before the therapies' risks and benefits have been properly evaluated.

9 Apr 2008

Double binding sites on tumor target may provide future combination therapy

Researchers from the University of Pennsylvania School of Medicine and colleagues at Merck Serono Research in Germany have found that two drugs bind to receptor sites on some tumors in different places at the same time, suggesting the possibility of a new combination therapy for certain types of cancer.

9 Apr 2008

Diabetes drug may hold potential as treatment for epilepsy, using same mechanism as ketogenic diet

Two years ago, University of Wisconsin-Madison scientists reported they had suppressed epileptic seizures in rats by giving them a glycolytic-inhibitor, inhibiting the brain's ability to turn sugar into excess energy and blocking the expression of seizure-related genes.

9 Apr 2008

Cholesterol, blood pressure control may reverse atherosclerosis in adults with diabetes

Aggressively lowering cholesterol and blood pressure levels below current targets in adults with type 2 diabetes may help to prevent – and possibly reverse – hardening of the arteries, according to new research supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health.

9 Apr 2008