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Drugs designed to disable enzyme TOPK could have anti-cancer benefits

Working with human colorectal cancer cells, a University of Minnesota team, led by cancer biologists Zigang Dong and Ann Bode, has found the potential culprit among a network of enzymes that relay signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death.

1 Aug 2007

Report reveals pregnancies exposed to accutane despite iPledge

Despite a mandatory program designed to prevent pregnant women from being exposed to the anti-acne medication Accutane and similar medications containing isotretinoin (a known teratogen or birth defect-causing agent), 122 pregnancies were exposed during the first year of the program, known as iPledge, a report revealed.

1 Aug 2007

New way to predict how cells will respond to targeted drug therapies

Models based on this approach could help doctors make better treatment choices for individual patients, who often respond differently to the same drug, and could help drug developers identify the ideal compounds on which to focus their research.

1 Aug 2007

Nanoparticles may provide safe pain control on the battlefield

University of Michigan scientists have received a pilot grant of nearly $1.3 million from the Defense Advanced Research Projects Agency to test whether nanoparticles can solve a pressing problem in battle zones like Iraq: how to administer sustained, safe doses of the most effective painkillers to injured soldiers, long before they can reach expert medical help.

1 Aug 2007

Huntington's disease study shows animal models on target

An international team of researchers has published a benchmark study showing that gene expression in several animal models of Huntington's Disease (HD) closely resembles that of human HD patients.

1 Aug 2007

First mouse model of schizophrenia

Johns Hopkins researchers have genetically engineered the first mouse that models both the anatomical and behavioral defects of schizophrenia, a complex and debilitating brain disorder that affects over 2 million Americans.

1 Aug 2007

Zebrafish provide clues to cure for Lou Gehrig's disease

A small tropical fish, the curiosity of a Geisinger research scientist and some college students have created the perfect storm of sorts in an attempt to find a cure for one of the world's most devastating neurological diseases.

1 Aug 2007

Shutting off a critical cancer gene causes cancers in mice to self-destruct

Killing cancerous tumors isn't easy, as anyone who has suffered through chemotherapy can attest.

1 Aug 2007

donepezil improves symptoms of severe Alzheimer's

A drug initially used to treat mild to moderate Alzheimer's disease improved the memory and global function of people with severe Alzheimer's disease and was safe and effective, according to a study published in the July 31, 2007, issue of Neurology, the medical journal of the American Academy of Neurology.

1 Aug 2007

Interferon alpha and sorafenib combined work better than either alone against kidney cancer

A combination of two drugs works better than either drug alone for patients with renal cell carcinoma, the most common form of kidney cancer, according to a pilot study led by Duke University Comprehensive Cancer Center researchers.

1 Aug 2007

Directed nanoparticles deliver gene therapy

After binding DNA segments to tiny iron-containing spheres called nanoparticles, researchers have used magnetic fields to direct the nanoparticles into arterial muscle cells, where the DNA could have a therapeutic effect.

31 Jul 2007

Maverick medics in the UK find a cheap way to save sight

The maverick medics who are ophthalmic surgeons in Manchester are prescribing the drug Avastin to victims of the most common cause of blindness in the elderly, age-related macular degeneration (AMD).

31 Jul 2007

Majority of FDA panel votes in favor of Avandia

GlaxoSmithKline has welcomed the nearly unanimous recommendation of an U.S. Food and Drug Administration's (FDA) advisory committee to support Avandia's (rosiglitazone maleate) continued availability to patients in the U.S.

30 Jul 2007

Takeda responds to FDA recommendation on Actos

Following a joint meeting today of the U.S. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee, Takeda Global Research & Development (TGRD) underscores its position that ACTOS(R) (pioglitazone HCl) offers a proven safety profile regarding the risk of cardiovascular disease.

30 Jul 2007

Avandia too risky says expert

One of the members of the advisory panel set up to discuss the future of the diabetes pill Avandia says it should be removed from the market because it is too risky and offers no advantage over other alternatives.

30 Jul 2007

A run to the coffee shop may prevent skin cancer

Researchers in the United States have discovered that the combination of daily exercise and a cup of coffee may help prevent skin cancer.

30 Jul 2007

Chinese authorities ban AIDS conference

An AIDS conference planned to take place in China in August has been banned by government authorities.

30 Jul 2007

ADHD drug given to toddlers

Reports in the UK suggest that almost 400,000 youngsters aged between 5 and 19 are being treated with Ritalin and similar drugs for attention deficit hyperactivity disorder, or ADHD, regardless of fears about the drugs' serious side-effects such as cardiovascular disorders, hallucinations and even suicidal thoughts.

30 Jul 2007

Polypill cure-for-all could become a killer

Doctors in Britain are warning that offering all men over 50 and all women over 60 a pill to protect them against heart disease and stroke, will only serve to encourage an unhealthy lifestyle.

30 Jul 2007

Researchers watch bacteria and antibiotics at the atomic level

A new understanding of an enzyme important for the transfer of genetic information in bacteria may help scientists improve current antibiotics and also create antibiotics that are less vulnerable to resistance.

27 Jul 2007