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Finding indicate why some kinds of Leukemia are more aggressive than others

New clues to why some kinds of leukemia are more aggressive and deadly than others are coming from research examining the types of genetic damage that allow some blood cells to grow out of control, scientists report.

28 Apr 2006

Potential vaccine for visceral leishmaniasis developed

Development of a fundamentally new "candidate," or potential, vaccine for visceral leishmaniasis (LEASH-ma-NIGH-a-sis), a parasitic disease that kills about 60,000 people annually, is reported in the current issue of ACS Chemical Biology. Spread by the bite of infected female sand flies, visceral leishmaniasis infects about 500,000 people annually, with the majority of cases occurring in India, Bangladesh, Nepal, Sudan and Brazil.

26 Apr 2006

New drug may revolutionize how chronic iron overload is treated in chronic anemia patients

Those with severe chronic anemias need frequent blood transfusions to remain healthy, but such frequent transfusions can cause a potentially deadly buildup of iron in the body, leading to heart and liver failure. The traditional treatment to remove excess iron is so onerous that many patients choose to forgo it, putting their own lives at risk. The results of an international study on deferasirox, a new drug that may revolutionize the way chronic iron overload is treated, will be published in the May 1, 2006, issue of Blood, the official journal of the American Society of Hematology.

26 Apr 2006

Four subtypes of blood cancer identified

Scientists at Dana-Farber Cancer Institute and collaborators have identified four distinct genetic subtypes of multiple myeloma, a deadly blood cancer, that have different prognoses and might be treated most effectively with drugs specifically targeted to those subtypes.

26 Apr 2006

Prefrontal cortex in the brain damaged by both alcoholism and chronic smoking

Alcoholism is commonly associated with chronic smoking, and both alcohol and nicotine are believed to act on the same brain region. Research builds upon previous research that identified four potential alcohol-sensitive genes in the prefrontal cortex, finding that smoking also influences the expression of these genes.

26 Apr 2006

Cause and treatment for aggressive head and neck cancer may have been found

Researchers report that they have found a potential molecular cause for the aggressive growth and spread of human head and neck squamous cell carcinoma, a highly malignant form of cancer with a very high death rate.

26 Apr 2006

Protein mutated in cancer found to be linked to diabetes

A study published by Nature has defined the function of p110 alpha, the flag-ship molecule of the eight member PI3K family, which is one of the most frequently activated pathways in cancer. The function of p110 alpha in the body has eluded researchers for over a decade but a new approach to generating mouse models, has allowed investigators to solve the mystery and yield important information for planned clinical trials with PI3K inhibitors.

25 Apr 2006

'Resonance' may be the reason for virologic failure in STI drug therapy

Researchers have been puzzled over why HIV-positive patients who have periodic, built in interruptions in their drug therapy reach a point where the therapy no longer reduces their viral loads, even in the absence of any evidence of acquired drug resistance.

25 Apr 2006

Alternative anti-inflammatory drugs promise less cardiovascular problems

New type of anti-inflammatory drugs may reduce COX-2 cardiovascular problems, says Queen's researcher

25 Apr 2006

New method allows heart beat triggers to be viewed and better understood

Researchers have developed unique chemical dyes that have made it possible to see what the naked eye has never seen before: action potentials, or voltage changes, of cardiac cells - including those deep inside the heart, which trigger and determine the pace of heartbeats.

25 Apr 2006

Enzyme research points to better drugs and improved industrial processes

Groundbreaking enzyme research could revolutionise the way drugs are made and have major implications for the industrial sector, including brewing, food processing, domestic cleaning and paper manufacturing.

From The University of Manchester 25 Apr 2006

Rare abdominal cancer diagnosis being looked at in a different manner

Their experience treating a rare type of abdominal cancer has helped physicians at Wake Forest University Baptist Medical Center make a new discovery that may change the way it is diagnosed.

24 Apr 2006

Study shows drugs work differently in the brains of men and women

A Johns Hopkins discovery could lead to tailored treatments for drug abuse and neurological diseases after providing what is believed to be the first evidence in people that amphetamines have a greater effect on men's brains than women's.

24 Apr 2006

Time for Russians to get serious about HIV/AIDS

Rapidly growing numbers of HIV-infections in Russia has prompted President Vladimir Putin to order officials to do more to inform Russians about the dangers of HIV/AIDS.

24 Apr 2006

Genetic clue found to Chronic Fatigue Syndrome

According to researchers from the Centers for Disease Control and Prevention (CDC), in the United States, there may well be a genetic reason why some people develop Chronic Fatigue Syndrome (CFS).

24 Apr 2006

Protein discovery opens up new therapeutic possibilities for epilepsy and neurodegenerative diseases

UC Irvine researchers have found that a protein best known for building connections between nerve cells and muscle also plays a role in controlling brain cell activity.

23 Apr 2006

Link between expectancy, visual cues and the desire to smoke

In a study recently published in the journal Neuropsychopharmacology, researchers at the Montreal Neurological Institute (MNI) and the Department of Psychology at McGill University found that when people expect to smoke in the near future, external cues such as watching someone smoke affects their brain more than their level of craving or how long they have gone without a cigarette.

23 Apr 2006

Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia

23 Apr 2006

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

A team of scientists from Lawrence Berkeley National Laboratory and the Scripps Research Institute has determined the crystal structure and molecular mechanisms of a key part of WRN, a protein that protects humans from premature aging and cancer.

23 Apr 2006

No support for medical use of marijuana from the FDA

According to the Food and Drug Administration (FDA), in the U.S. there are no scientific grounds for the medical use of use of marijuana and the agency is highly critical of attempts by individual states to legalise it.

23 Apr 2006