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Details of protein-cleaving complex key to microbe's survival may improve drug design

With the hope of designing more effective treatments for tuberculosis (TB), scientists from the U.S. Department of Energy's Brookhaven National Laboratory and collaborating institutions have published the first detailed reports on the biochemistry and structure of a protein-cleaving complex that is essential to the TB bacterium's survival.

9 Mar 2006

New way to study proteins in live cells

For the first time, Johns Hopkins researchers were able to easily jumpstart the activity of a well-known cancer protein in live cells with a small molecule, a strategy that pinpointed key players in the cancer process and can be used to determine new therapeutic targets.

9 Mar 2006

Genetic switch that turns off an oxygen-poor cell's combustion engine - finding has potential to limit toxic molecules

Johns Hopkins researchers have discovered a previously unrecognized role played by the gene HIF-1 as it helps cell survive when a lack of oxygen decreases production of an energy-rich molecule called ATP and increases production of toxic molecules.

9 Mar 2006

Novel compound may help fight obesity

A new study reveals an attractive new target for therapies aimed at the treatment of obesity and related metabolic disorders, researchers report in the March Cell Metabolism.

9 Mar 2006

Drug shortfall as more than 5,000 conditions need medication

Only seven per cent of drug applications for treating people with rare diseases were approved in Europe between 2000 and 2004, despite the fact that there are currently more than 5,000 conditions needing medication.

9 Mar 2006

Taipan venom may stop excessive bleeding during vascular surgery

A blood-clotting protein in taipan venom has been identified by Queensland University of Technology PhD researcher Liam St Pierre to rapidly stop excessive bleeding during vascular surgery and major trauma.

9 Mar 2006

Soy protein, almonds, plant sterol enriched margarines, oats and barley among most effective cholesterol-lowering foods

Cholesterol-lowering foods such as soy protein, almonds, plant sterol enriched margarines, oats and barley may reduce cholesterol levels more effectively when eaten in combination, says a new University of Toronto study by Professor David Jenkins.

9 Mar 2006

Inflammation is a crucial and dangerous step in the development of obesity

New research by the University of Warwick's Warwick Medical School shows that the biggest health threat to fat and obese people isn't the fat itself but the fact that the fat fuels a killer inflammation response in people.

8 Mar 2006

New findings on antidepressants during pregnancy are reason for caution, not alarm

Until recently, antidepressants - especially selective serotonin reuptake inhibitors (SSRIs) - were considered fairly safe for pregnant women.

8 Mar 2006

Revatio now available in the UK

Patients in the UK suffering from a rare life-threatening heart condition, pulmonary arterial hypertension (PAH), could soon be offered a new treatment.

8 Mar 2006

Cat in the clear - but experts argue over "fire blanket" pandemic plan

At the conclusion of a meeting in Geneva on how to limit the effects of a future flu pandemic, experts remain divided on the chance of success.

8 Mar 2006

MS sufferers lobby for return of Tysabri

Despite the deaths of two people among the thousands treated with a promising multiple sclerosis drug, MS patients are trying to persuade the U.S. government to allow the drug back onto the market.

8 Mar 2006

Potential new treatment for Huntington and Parkinson patients

A potential new treatment for neurodegenerative disorders, which seems to be able to reduce the toxic protein aggregates characteristic of many of these diseases, is published online this week in the journal Proceedings of the National Academy of Sciences.

7 Mar 2006

Discovery of compound that reduces hallmark lesions of Alzheimer's disease in mice

Researchers at UC Irvine have found that a new compound not only relieves the cognitive symptoms of Alzheimer's disease, but also reduces the two types of brain lesions that are hallmarks of this devastating disease, thereby blocking its progression.

7 Mar 2006

Will the FDA rise to the occasion and admit their natalizumab mistake?

When Anita Louise Smith enrolled in an experimental drug trial in 2002 in Colorado, she had a diagnosis of multiple sclerosis but no symptoms and was looking to reduce the chances of being ravaged by the disease.

7 Mar 2006

Genes play a key role in stress response

Both nature and nurture - genetic makeup and the environment experienced through life - combine to influence health and well-being, Duke University Medical Center researchers and their colleagues have determined in four new studies.

7 Mar 2006

Researchers discover cause of episodic ataxia type-2

Researchers at the Albert Einstein College of Medicine of Yeshiva University have discovered the underlying cause of a type of ataxia, hereditary disorders characterized by poor balance, loss of posture and difficulty performing rapid coordinated movement.

7 Mar 2006