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Better tracking system needed to check the safety of new medical devices

A recently released report by the Institute of Medicine (IOM) says that a better system is needed by U.S. health officials for tracking the safety of medical devices after they are approved for sale, especially ones used to treat children.

19 Jul 2005

Studies explore genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2

Two papers in the August 1 issue of Genes & Development explore the genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2.

19 Jul 2005

A study analyzes the most important factors leading to death or liver transplant in drug-induced liver disease

Drug-induced liver disease (DILD), a potential complication seen with some medications, is usually not life-threatening, but may occasionally be more severe with a high mortality, requiring a liver transplant in selected cases.

18 Jul 2005

Tamiflu may treat avian flu virus

Experiments in mice show that an antiviral drug currently used against annual influenza strains also can suppress the deadly influenza virus that has spread from birds to humans, killing dozens of people in Vietnam, Cambodia and Thailand since early 2004.

18 Jul 2005

ACE inhibitors should be available at no cost to the 8 million Americans over age 65 who have diabetes

Nothing in life is free, the old saying goes. But maybe some things should be, according to a new University of Michigan Health System study.

18 Jul 2005

New finding has potentially major implications for anti-angiogenic therapy

Scientists supported by the National Institute of Dental and Craniofacial Research (NIDCR) have added a key new piece to the puzzle of how tumor cells induce new blood vessels to form and fuel their abnormal growth, a well-known process called angiogenesis.

18 Jul 2005

Compound derived from cottonseed could help improve the effectiveness of chemotherapy at treating head and neck cancer

The findings, which appear in the July issue of the journal Molecular Cancer Therapeutics, could lead to a treatment that provides an effective option to surgically removing the cancer, helping patients preserve vital organs involved in speech and swallowing.

18 Jul 2005

Asthma may be linked to a decreased risk of brain cancer

According to new research there is a suggestion that gene variants known to raise the risk of asthma, might also decrease the risk of a common type of brain cancer that progresses rapidly and is fatal.

18 Jul 2005

Genome studies may help target new drugs to fight them

One parasite causes a deadly sleeping sickness in Africa. The second damages the internal organs of millions of Latin Americans. The third causes terrible lesions on the face or limbs of victims from Brazil to India.

18 Jul 2005

New molecular insights may one day lead to opportunities to stave off old age

Delving deep into the molecular subtleties of a strain of mice engineered to age rapidly, scientists have found that an accumulation of genetic mutations prompts a cascade of programmed cell death that seems to underpin the aging process.

18 Jul 2005

Scientists sequence the genomes of three species of parasites responsible for causing diseases that kill or cripple millions

Howard Hughes Medical Institute (HHMI) scientists who participated in the project say the sequencing of the genomes of the parasitic protozoa that cause Chagas disease, African sleeping sickness, and leishmaniasis, could significantly impact world health. Some of the genes discovered may prove to be good drug and vaccine targets.

17 Jul 2005

Malpractice litigation has little to do with erratic quality of health care

Conventional wisdom holds that malpractice lawsuits are the bane of modern medicine, with high insurance premiums driving doctors from the profession and the threat of lawsuits discouraging health-care employees from reporting and correcting medical mistakes.

17 Jul 2005

RNA dynamics may help in drug design

Biophysicists have developed a method for studying, in real time, a nanoscale "docking and undocking" interaction between small pieces of ribonucleic acid (RNA), a technique that may be broadly useful in studying structural changes in RNA that affect its function.

17 Jul 2005

Lipid helps cell wall protein fold into proper shape

A protein that provides a vital passage through a bacterium's outer cell wall will misfold and malfunction if that wall is built of the 'wrong' material, scientists at The University of Texas Medical School at Houston report in a finding that has long-term implications for understanding diseases caused by misfolded proteins such as cystic fibrosis, Alzheimer's disease, and mad cow disease.

17 Jul 2005

PGE2 may be a target for Celebrex therapy

A product produced by lung cancer tumors fuels the cells that suppress immune function in patients and may be a target for Celebrex therapy, giving oncologists another weapon to fight cancer, according to a study by researchers at UCLA's Jonsson Cancer Center.

17 Jul 2005

Scientists have begun to clarify how one of the body's molecules controls the trafficking of T cells through the blood

...lymph nodes and on to tissues to fight infection -- a crucial response that sometimes goes awry, attacking the body's own tissues and causing autoimmune diseases.

17 Jul 2005

New research on atrial fibrillation

Atrial fibrillation is an irregular heartbeat (arrhythmia) in which the atria, or upper chambers of the heart, beat quickly and inconsistently.

17 Jul 2005

Complicated plasminogen system yields potential therapeutic target; Implications for aging and degenerative diseases

Skeletal muscles naturally repair themselves very efficiently after injury. But when they don’t, otherwise successful recovery following damage from overuse during exercise, surgery or trauma can be stymied. Furthermore, as we age, muscle repair slows noticeably, and in Duchenne Muscular Dystrophy and other degenerative muscle diseases, normal repair functions can’t cope with disease progression.

14 Jul 2005

FDA panel says asthma drugs should stay on market but must carry warnings

The U.S. Food and Drug Administration (FDA) advisory panel has declared that three asthma drugs are safe enough to stay on the market, after concerns that in rare cases they raise the risk of severe asthma.

14 Jul 2005

Researchers gain better understanding of how nerves need to be reconnected after spinal cord injury

Nerve cells relay messages at blink-of-the-eye speeds by squirting chemicals called neurotransmitters across tiny gaps called synapses to awaiting message receptors. But lots of different receptors and neurotransmitters work simultaneously. Which goes where to send the proper message?

13 Jul 2005

Drugs News and Research

Better tracking system needed to check the safety of new medical devices

Studies explore genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2

A study analyzes the most important factors leading to death or liver transplant in drug-induced liver disease

Tamiflu may treat avian flu virus

ACE inhibitors should be available at no cost to the 8 million Americans over age 65 who have diabetes

New finding has potentially major implications for anti-angiogenic therapy

Compound derived from cottonseed could help improve the effectiveness of chemotherapy at treating head and neck cancer

Asthma may be linked to a decreased risk of brain cancer

Genome studies may help target new drugs to fight them

New molecular insights may one day lead to opportunities to stave off old age

Scientists sequence the genomes of three species of parasites responsible for causing diseases that kill or cripple millions

Malpractice litigation has little to do with erratic quality of health care

RNA dynamics may help in drug design

Lipid helps cell wall protein fold into proper shape

PGE2 may be a target for Celebrex therapy

Scientists have begun to clarify how one of the body's molecules controls the trafficking of T cells through the blood

New research on atrial fibrillation

Complicated plasminogen system yields potential therapeutic target; Implications for aging and degenerative diseases

FDA panel says asthma drugs should stay on market but must carry warnings

Researchers gain better understanding of how nerves need to be reconnected after spinal cord injury

Drug Discovery - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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