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Virome analysis reveals clues for increased risk of type 1 diabetes in children

New results from The Environmental Determinants of Diabetes in the Young study show an association between prolonged enterovirus infection and the development of autoimmunity to the insulin-producing pancreatic beta-cells that precedes type 1 diabetes.

2 Dec 2019

Doughnut-shaped circles of ecDNA provide tumor cells with a malignant twist

Deoxyribonucleic acid or DNA encodes information, not only in its sequence but also in its shape.

21 Nov 2019

Self-destructive mitochondria may set the stage for neurodegeneration in ALS

Northwestern Medicine scientists have discovered a new phenomenon in the brain that could explain the development of early stages of neurodegeneration seen in diseases such as ALS, which affects voluntary muscle movement such as walking and talking.

18 Nov 2019

Researchers decode molecular structure of cytochrome bd oxidase from E. coli

Both humans and many other creatures need oxygen for survival. In the conversion of nutrients into energy, the oxygen is converted to water, for which the enzyme oxidase is responsible. It represents the last step of the so-called respiratory chain.

14 Nov 2019

Study unravels how insulin interacts with its receptor

Since the discovery of insulin nearly 100 years ago, scientists have explored how it interacts with its receptor with the goal of improving the ability of therapeutic insulins to mimic the way insulin works in the body.

14 Nov 2019

New vaccine strategy shows promise against HIV

A collaborative team of scientists has made a successful proof-of-principle demonstration of an advanced HIV vaccine strategy--an approach that may also work in protecting people from an array of other deadly infectious diseases.

7 Nov 2019

CryoCapCell appoint Labtech as UK distributor

Labtech International has been appointed as the UK and Ireland distributor of CryoCapCell, the France-based manufacturer of the technology-leading HPM Live μ high pressure freezing system.

From Labtech International Ltd 6 Nov 2019

Scientists visualize complex cellular machine to yield new insights in cancer

Cellular machines that control chromosome structure, such as the RSC complex, are mutated in about one-fifth of all human cancers.

31 Oct 2019

Discovery of 'cellular bike couriers' could shed light on disease spreading mechanisms

A previously unknown component of our cells that delivers proteins like a bike courier in heavy traffic could shed light on the mechanisms that allow cells to spread in diseases such as cancer.

31 Oct 2019

KAUST researchers one step closer to understanding brain function

Researchers at King Abdullah University of Science and Technology (KAUST) are officially one-step closer to understanding the brain and its function.

29 Oct 2019

Scientists solve first structure of human cotransporter protein KCC1

In work that could someday improve treatments for epilepsy, UT Southwestern scientists have published the first three-dimensional structure of a member of a large family of human proteins that carry charged particles – ions – across the cell membrane.

29 Oct 2019

Researchers use 3D electron microscopy to unravel dense networks in the cerebral cortex

Unlike any other organ, our brains contain extremely densely packed networks of membranous cables that are used by our about 86 billion nerve cells for communication amongst each other.

24 Oct 2019

Columbia researchers capture new detailed images of a temperature-sensing molecule

Columbia University researchers have captured new detailed images of a temperature-sensing molecule in its open, intermediate, and closed states.

21 Oct 2019

Discovery about DNA-reeling bacteria can help inform strategies to stop bacterial infection

A new study from Indiana University has revealed a previously unknown role a protein plays in helping bacteria reel in DNA in their environment -- like a fisherman pulling up a catch from the ocean.

21 Oct 2019

New technique reveals how the brain responds to light signals received by the retina

In recent decades, scientists have learned a great deal about how different neurons connect and send signals to each other. But it's been difficult to trace the activity of individual nerve fibers known as axons, some of which can extend from the tip of the toe to the head.

15 Oct 2019

Understanding protein aggregation over time can help decipher early stages of Parkinson's

One of the biggest difficulties in treating Parkinson's disease, a progressive neurodegenerative disorder, is the understanding of when it starts.

11 Oct 2019

Scientists uncover details of antibody response to Ebola virus vaccine

In the recurring, deadly Ebola outbreaks in parts of Africa, today's health workers now have at least some tools to fight the disease: vaccines. Vaccines against Ebola have been administered to over 100,000 people to date, but they are barely out of the experimental stage.

10 Oct 2019

New insight into presynaptic distribution and profile of mitochondria in calyx of Held

The ability to hear relies on neurons to constantly transmit information at very rapid timescales. This rapid rate of information transmission results in intense energetic demands. Within our cells, microscopic power plants called mitochondria provide the main source of energy keeping our bodies moving.

9 Oct 2019

Exploiting the weak spot in pathogenic bacteria to develop new antibiotics

Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of "ammunition" because of more and more frequently occurring resistances.

4 Oct 2019

Mount Sinai researchers discover how DNA polymerase delta duplicates the genome

Mount Sinai researchers have discovered how the enzyme DNA polymerase delta works to duplicate the genome that cells hand down from one generation to the next. In a study published in Nature Structural & Molecular Biology, the team also reported how certain mutations can modulate the activity of this enzyme, leading to cancers and other diseases.

3 Oct 2019