Endocrine News and Research

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Researchers find some similarities between SPN and PET

Solid-pseudopapillary neoplasm (SPN) of the pancreas is relatively rare. There are some similarities between SPN and pancreatic endocrine tumor (PET), especially the non-functioning ones, in clinical and pathological manifestations.

18 Mar 2010

Expectant mothers’ spatial memory ability reduces during later stages of pregnancy

New research has found that pregnant women's ability to remember the position of objects previously seen is reduced as pregnancy progresses. These findings will be presented this week at the annual Society for Endocrinology BES conference in Manchester.

18 Mar 2010

PAREXEL genotypes over 10,000 potential study participants to identify 400 CYP2D6 poor metabolizers

PAREXEL International Corporation, a leading global biopharmaceutical services provider, today announced that it has completed a large and complex pharmacogenetics-based early phase study. The study was conducted in a healthy volunteer population of poor metabolizers of Cytochrome P450 2D6 (CYP2D6), an important enzyme involved in the metabolism of drugs. The study monitored the QTc interval following administration of a neurological treatment, which has been shown to have a higher drug exposure in poor metabolizers of CYP2D6.

From Parexel 17 Mar 2010

Patients with chronic conditions need support to re-enter employment

A new study has identified a significant shortfall in patients with life-long but treatable conditions re-entering employment. The research is being presented at the annual Society for Endocrinology BES meeting in Manchester.

17 Mar 2010

Flu infection during pregnancy may increase risk of schizophrenia in offspring

Rhesus monkey babies born to mothers who had the flu while pregnant had smaller brains and showed other brain changes similar to those observed in human patients with schizophrenia, a study at the University of Wisconsin-Madison in collaboration with the University of North Carolina at Chapel Hill has found.

12 Mar 2010

Cytokeratins 8 and 18 can strongly enhance breast cancer drug fulvestrant's anti-estrogenic activity

Women's responsiveness to the second-line breast cancer drug fulvestrant may depend on whether the cancer cells are expressing two key proteins, Indiana University Bloomington scientists report in this month's Cancer Biology & Therapy.

11 Mar 2010

BPA potentially puts developing infants as well as fetuses at risk, say researchers

Swiss researchers examining exposure pathways for a common chemical used in plastic containers and linings of cans find infants have the highest estimated levels of Bisphenol A (BPA), with exposures falling with rising age. While estimated levels are well below the Tolerable Daily Intake (TDI) set by European authorities, the findings are important in that BPA is thought to impact human development and is classified as an endocrine disrupting chemical, potentially putting developing infants at risk, as well as fetuses if pregnant mothers are exposed.

10 Mar 2010

FDA invites "Little Women" to present research on dangers of HPV vaccines

Called the "Little Women," six women who have spent the past three years listening, documenting and researching parental concerns about Gardasil have been invited to formally present their information to the FDA on March 12. FDA participants include the Office of Communication, Outreach and Development/Center of Biologics (CBER), Office of Biostatistics and Epidemiology, and Office of Vaccines Research and Review.

9 Mar 2010

Usage of gonadotropins in assisted reproductive technologies significantly improves outcomes

The U.S. infertility specialty has empirically incorporated greater amounts of human menopausal gonadotropin (hMG) into stimulation protocols, according to a new review article, "Gonadotropins in the Treatment of Infertility" by George T. Koulianos, MD, published in a recent issue of US Obstetrics & Gynecology, supported by an educational grant from Ferring Pharmaceuticals. The article reviews the wealth of clinical evidence supporting this trend, and demonstrates how the use of gonadotropins in the treatment of infertility, especially in assisted reproductive technologies, has significantly improved outcomes.

9 Mar 2010

Natural Solutions offers information about thyroid disease and thyroid medications

Is your thyroid making you fat? Around 27 million Americans have thyroid disease — and almost half don't know it. Thyroid disease arises when the hormone-producing gland at the base of your throat goes out of whack, triggering weight fluctuation, tiredness, and emotional ups and downs, among other symptoms.

5 Mar 2010

Dermatologist speaks about common forms of hair loss and treatment options at 68th Annual Meeting

For many women, unexplained hair loss can take a significant psychological toll on their overall quality of life. From altering their hairstyle to hide a thinning part to scaling back their hair care regimen in an effort to halt further hair loss, women try countless ways to cover up this problem - and the results are often lukewarm at best.

4 Mar 2010

Androxal Type C meeting: Repros Therapeutics receives FDA’s version of minutes

Repros Therapeutics Inc. today announced that the Company has received the FDA’s version of the minutes of the Type C meeting held on January 25, 2010. The minutes confirmed the Company’s interpretation of the points the Agency made during the meeting. In correspondence from the FDA prior to the meeting the Agency noted that they could not currently agree with the Company’s stated indication for the use of Androxal® in the treatment of secondary hypogonadism in men wishing to preserve fertility.

4 Mar 2010

Association between depression and obesity bidirectional

Obesity appears to be associated with an increased risk of depression, and depression also appears associated with an increased risk of developing obesity, according to a meta-analysis of previously published studies in the March issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

2 Mar 2010

High levels of anti-aging hormone may increase cancer mortality in older men

According to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM), older men with high levels of the hormone IGF-I (insulin-like growth factor 1) are at increased risk of cancer death, independent of age, lifestyle and cancer history.

2 Mar 2010

$Visceral fat can increase fracture risk in obese teenage girls$

Visceral fat can increase fracture risk in obese teenage girls

According to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM), obese teenage girls with a greater ratio of visceral fat (fat around internal organs) to subcutaneous fat (fat found just beneath the skin) are likely to have lower bone density than peers with a lower ratio of visceral to subcutaneous fat.

2 Mar 2010

Endocrine News and Research

Researchers find some similarities between SPN and PET

Expectant mothers’ spatial memory ability reduces during later stages of pregnancy

PAREXEL genotypes over 10,000 potential study participants to identify 400 CYP2D6 poor metabolizers

Patients with chronic conditions need support to re-enter employment

Flu infection during pregnancy may increase risk of schizophrenia in offspring

Cytokeratins 8 and 18 can strongly enhance breast cancer drug fulvestrant's anti-estrogenic activity

BPA potentially puts developing infants as well as fetuses at risk, say researchers

FDA invites "Little Women" to present research on dangers of HPV vaccines

Usage of gonadotropins in assisted reproductive technologies significantly improves outcomes

Natural Solutions offers information about thyroid disease and thyroid medications

Dermatologist speaks about common forms of hair loss and treatment options at 68th Annual Meeting

Androxal Type C meeting: Repros Therapeutics receives FDA’s version of minutes

Association between depression and obesity bidirectional

High levels of anti-aging hormone may increase cancer mortality in older men

Visceral fat can increase fracture risk in obese teenage girls

NPS Pharmaceuticals supports second annual U.S. Rare Disease Day observance

UAMS researchers identify age-related mechanism as primary cause of osteoporosis

GlaxoSmithKline responds to Staff Report on GlaxoSmithKline and the Diabetes Drug Avandia

PAREXEL International expands capabilities by opening new early phase unit in Port Elizabeth, South Africa

Obesity doubles the risk of developing kidney stones: Study

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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