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Wistar findings suggest link between colon microbiome and genome stability

Colorectal cancer develops in what is probably the most complex environment in the human body, a place where human cells cohabitate with a colony of approximately 10 trillion bacteria, most of which are unknown.

7 Apr 2014

Too little or too much of SRPK1 enzyme promotes cancer, shows research

Researchers at the University of California, San Diego School of Medicine have found that too little or too much of an enzyme called SRPK1 promotes cancer by disrupting a regulatory event critical for many fundamental cellular processes, including proliferation.

4 Apr 2014

Findings may help develop targeted drugs to fight cancer, neurodegenerative diseases

The molecular details of how zinc, an essential trace element of human metabolism, interacts with the enzyme caspase-3, which is central to apoptosis or cell death, have been elucidated in a new study led by researchers at Virginia Commonwealth University. The study is featured on the cover of the April issue of the journal Angewandte Chemie's International Edition.

3 Apr 2014

Expert in gene therapy joins The Children's Hospital of Philadelphia

Beverly L. Davidson, Ph.D., a nationally prominent expert in gene therapy, is joining The Children's Hospital of Philadelphia (CHOP) today.

2 Apr 2014

FDA grants orphan drug designation to ERYTECH’s lead product for AML treatment

ERYTECH Pharma, a French biopharmaceutical company that develops innovative treatments for acute leukemia and other oncology indications with unmet medical needs, announces that its lead product GRASPA®/ERY-ASP has been granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) for the treatment of Acute Myeloid Leukemia (AML), an aggressive form of blood cancer.

2 Apr 2014

Discovery could lead to new therapies for people with celiac disease

Researchers at McMaster University have discovered a key molecule that could lead to new therapies for people with celiac disease, an often painful and currently untreatable autoimmune disorder.

1 Apr 2014

New research shows obesity is linked to our ability to digest carbohydrates

New research indicates that obesity in the general population may be genetically linked to how our bodies digest carbohydrates.

1 Apr 2014

Otsuka inks agreement with Eisai to acquire rights to hematological cancer treatment Dacogen

Otsuka Pharmaceutical Co., Ltd. has announced an agreement with Eisai Inc., a U.S. subsidiary of Eisai Co., Ltd. to acquire rights to the hematological cancer treatment Dacogen and to an enzyme inhibitor, E7727.

31 Mar 2014

Otsuka acquires rights to develop and sell Eisai’s DACOGEN in the US, Canada and Japan

Eisai Inc., a subsidiary of Tokyo-based Eisai Co., Ltd., today announced the sale and assignment of its rights to a worldwide exclusive license for DACOGEN® (decitabine) for Injection to Otsuka Pharmaceutical Co., Ltd., giving Otsuka full development and commercialization rights for the product in the former Eisai territories of the United States, Canada and Japan.

31 Mar 2014

New gene-editing system holds potential for treating many genetic disorders

Using a new gene-editing system based on bacterial proteins, MIT researchers have cured mice of a rare liver disorder caused by a single genetic mutation.

31 Mar 2014

Carb breakdown gene linked to obesity, researchers find

Researchers at King's College London and Imperial College London have discovered that people with fewer copies of a gene coding for a carb-digesting enzyme may be at higher risk of obesity. The findings, published in Nature Genetics, suggest that dietary advice may need to be more tailored to an individual's digestive system, based on whether they have the genetic predisposition and necessary enzymes to digest different foods.

31 Mar 2014

Johns Hopkins neuroscientists identify cause of brain degeneration in Huntington's disease

Working with genetically engineered mice, Johns Hopkins neuroscientists report they have identified what they believe is the cause of the vast disintegration of a part of the brain called the corpus striatum in rodents and people with Huntington's disease: loss of the ability to make the amino acid cysteine.

29 Mar 2014

Certain inherited DNA sequences may affect prognosis of bladder cancer patients

While patients diagnosed with bladder cancer usually face a favorable prognosis, many experience recurrence after treatment. Because frequent, painful screenings are needed to identify recurrences, the ablility to identify patients at high risk of recurrent cancer could help to improve quality of life for all bladder cancer patients.

29 Mar 2014

Study highlights benefits of using multiple injections to treat Sanfilippo syndrome type III B

New insight has been gained into treating an inherited disorder that creates serious neurological and behavioral disabilities in children and usually leads to death in the teen years.

28 Mar 2014

Research findings help explain rare genetic disorder that causes immunodeficiency syndrome

IRCM researchers led by Javier M. Di Noia, PhD, uncovered a new function of AID, a crucial enzyme for the immune response. The discovery, recently published by the scientific journal Proceedings of the National Academy of Sciences, helps explain a rare genetic disorder that causes an immunodeficiency syndrome.

28 Mar 2014

Researchers provide new clues for adult vertebrate tissue regeneration

The reason why some animals can regenerate tissues after severe organ loss or amputation while others, such as humans, cannot renew some structures has always intrigued scientists. In a study now published in PLOS ONE, a research group from Instituto Gulbenkian de Ci-ncia (IGC, Portugal) led by Joaqu-n Rodr-guez Le-n provided new clues to solve this central question by investigating regeneration in an adult vertebrate model: the zebrafish.

27 Mar 2014

Enzyme News and Research

Wistar findings suggest link between colon microbiome and genome stability

Too little or too much of SRPK1 enzyme promotes cancer, shows research

Findings may help develop targeted drugs to fight cancer, neurodegenerative diseases

Expert in gene therapy joins The Children's Hospital of Philadelphia

FDA grants orphan drug designation to ERYTECH’s lead product for AML treatment

Discovery could lead to new therapies for people with celiac disease

New research shows obesity is linked to our ability to digest carbohydrates

Otsuka inks agreement with Eisai to acquire rights to hematological cancer treatment Dacogen

Otsuka acquires rights to develop and sell Eisai’s DACOGEN in the US, Canada and Japan

New gene-editing system holds potential for treating many genetic disorders

Carb breakdown gene linked to obesity, researchers find

Johns Hopkins neuroscientists identify cause of brain degeneration in Huntington's disease

Certain inherited DNA sequences may affect prognosis of bladder cancer patients

Study highlights benefits of using multiple injections to treat Sanfilippo syndrome type III B

Research findings help explain rare genetic disorder that causes immunodeficiency syndrome

Researchers provide new clues for adult vertebrate tissue regeneration

Expert highlights the importance of gender-specific approach for treating diabetes mellitus

Patients with genetic variants are likely to experience bladder cancer recurrence

Oral cancer drug improves outcomes in women with resistant gynecologic cancers

SLU researchers awarded NIH grants to search for a drug to cure hepatitis B

Biochemistry eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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