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Combination of etoposide with compounds that interfere with cell division improves therapeutic window for cancer treatments

A large part of the effort dedicated to cancer research is directed towards the search for combinations of existing drugs-many of which have already been introduced into clinical practice-that permit higher overall survival rates and improvements in the quality of life of cancer patients.

7 Feb 2014

Scientists reveal important degradation pathway of sulpho-glucose

By discovering sulpho-glycolysis, researchers of the University of Konstanz reveal an important degradation pathway.

5 Feb 2014

Selcia, University of Edinburgh collaborate to develop novel treatments for sleeping sickness

An initiative is under way to develop new drugs for a devastating tropical disease that threatens almost 70 million people in Africa.

4 Feb 2014

ACE protein overexpression elevates immune responses and prevents Alzheimer's-like cognitive decline

Many people with high blood pressure are familiar with ACE inhibitors, drugs that widen blood vessels by limiting activity of ACE - angiotensin-converting enzyme - a naturally occurring protein found in tissues throughout the body.

4 Feb 2014

Study shows how pesticides may contribute to development of Parkinson's disease

New research shows how pesticides may increase the risk of Parkinson's disease and that people with certain gene variants may be more susceptible to the disease. The research is published in the February 4, 2014, print issue of Neurology®, the medical journal of the American Academy of Neurology.

4 Feb 2014

New noninvasive chemical probe detects common species of staph bacteria in the body

Chances are you won't know you've got a staph infection until the test results come in, days after the symptoms first appear. But what if your physician could identify the infection much more quickly and without having to take a biopsy and ship it off for analysis?

From Integrated DNA Technologies 3 Feb 2014

New insight into how gut bacteria digest fibre

New insight into how gut bacteria digest fibre could lead to advances in areas as diverse as health and environmentally-friendly biofuels.

31 Jan 2014

Researchers identify components of C. diff bacteria that can be used to develop better treatment

Rhode Island Hospital researchers have identified components in Clostridium difficile (C. diff) that may lead to new diagnostic tools, and ultimately more timely and effective treatment for this often fatal infection. C. diff is a spore-forming bacterium that causes severe diarrhea and is responsible for 14,000 deaths annually in the U.S. The study is published online in advance of print in the Journal of Molecular Diagnostics.

31 Jan 2014

New molecule could help lower diabetic patients' risk of developing dementia or Alzheimer's

Researchers at the Hebrew university of Jerusalem have created a molecule that could potentially lower diabetic patients' higher risk of developing dementia or Alzheimer's disease.

30 Jan 2014

Researchers use natural DNA molecules to build DNA nanoarchitectures

A Rutgers-Camden scholar is performing research as part of a collaborative effort with Arizona State University to make significant advancements in nanotechnology.

30 Jan 2014

Johns Hopkins researchers discover epilepsy drug reduces obesity-related blood sugar levels

Johns Hopkins researchers have discovered that valproic acid, a widely prescribed drug for treating epilepsy, has the additional benefits of reducing fat accumulation in the liver and lowering blood sugar levels in the blood of obese mice.

30 Jan 2014

Omeros announces positive results from Phase 2a trial of OMS824 in patients with schizophrenia

Omeros Corporation today announced positive results from a Phase 2a clinical trial of OMS824, the company's phosphodiesterase 10 (PDE10) inhibitor, in which the drug was well tolerated and demonstrated comparable systemic pharmacokinetics when administered alone and concomitantly with approved antipsychotic agents in patients with schizophrenia. OMS824 selectively inhibits PDE10, an enzyme expressed in areas of the brain linked to a wide range of diseases that affect cognition, including schizophrenia and Huntington's disease.

29 Jan 2014

QUT researchers get new insight into ovarian cancer

Queensland scientists have made significant inroads into our understanding of the deadliest form of ovarian cancer after identifying two enzymes that make it resistant to chemotherapy.

29 Jan 2014

CU receives cooperative agreement to develop technological system to determine effects chemical agents

The University of Colorado Boulder has been awarded a cooperative agreement worth up to $14.6 million from the Defense Advanced Research Projects Agency (DARPA) to develop a new technological system to rapidly determine how drugs and biological or chemical agents exert their effects on human cells.

29 Jan 2014

NEBioCalculator: New online tool offers support for molecular biology experiments

NEBioCalculator, a new online "conversions and calculations" tool developed by New England Biolabs, offers bench-side support for molecular biology experimental planning.

From New England Biolabs 29 Jan 2014

Biologists identify protein targets for next-generation of anti-HIV drugs

People infected with the Human Immunodeficiency Virus (HIV) can stave off the symptoms of AIDS thanks to drug cocktails that mainly target three enzymes produced by the virus, but resistant strains pop up periodically that threaten to thwart these drug combos.

29 Jan 2014

Transgenic mouse model validates mutant IDH2 protein as candidate for targeted anticancer therapies

In recent years, mutations in two metabolic enzymes, isocitrate dehydrogenase-1 and 2 (IDH1 and IDH2), have been identified in approximately 20 percent of all acute myeloid leukemias (AML). As a result, mutant IDH proteins have been proposed as attractive drug targets for this common form of adult leukemia.

29 Jan 2014

New molecule reduces diabetic patients' higher risk of developing dementia, Alzheimer's

Researchers at the Hebrew university of Jerusalem have created a molecule that could potentially lower diabetic patients' higher risk of developing dementia or Alzheimer's disease.

28 Jan 2014

Curie-Cancer, Servier renew partnership to identify new therapeutic targets for triple negative breast cancer

Curie-Cancer, the body which leads the Institut Curie's industry partner research activity, and Servier, today announce that they have renewed their partnership with the aim of identifying therapeutic targets for treating ‘triple negative’ breast cancers. The partnership will continue for a further three years.

28 Jan 2014

Johns Hopkins researchers reveal how non-CpG methylation may contribute to Rett Syndrome

In normal development, all cells turn off genes they don’t need, often by attaching a chemical methyl group to the DNA, a process called methylation. Historically, scientists believed methyl groups could only stick to a particular DNA sequence: a cytosine followed by a guanine, called CpG. But in recent years, they have been found on other sequences, and so-called non-CpG methylation has been found in stem cells, and in neurons in the brain.

28 Jan 2014

Enzyme News and Research

Combination of etoposide with compounds that interfere with cell division improves therapeutic window for cancer treatments

Scientists reveal important degradation pathway of sulpho-glucose

Selcia, University of Edinburgh collaborate to develop novel treatments for sleeping sickness

ACE protein overexpression elevates immune responses and prevents Alzheimer's-like cognitive decline

Study shows how pesticides may contribute to development of Parkinson's disease

New noninvasive chemical probe detects common species of staph bacteria in the body

New insight into how gut bacteria digest fibre

Researchers identify components of C. diff bacteria that can be used to develop better treatment

New molecule could help lower diabetic patients' risk of developing dementia or Alzheimer's

Researchers use natural DNA molecules to build DNA nanoarchitectures

Johns Hopkins researchers discover epilepsy drug reduces obesity-related blood sugar levels

Omeros announces positive results from Phase 2a trial of OMS824 in patients with schizophrenia

QUT researchers get new insight into ovarian cancer

CU receives cooperative agreement to develop technological system to determine effects chemical agents

NEBioCalculator: New online tool offers support for molecular biology experiments

Biologists identify protein targets for next-generation of anti-HIV drugs

Transgenic mouse model validates mutant IDH2 protein as candidate for targeted anticancer therapies

New molecule reduces diabetic patients' higher risk of developing dementia, Alzheimer's

Curie-Cancer, Servier renew partnership to identify new therapeutic targets for triple negative breast cancer

Johns Hopkins researchers reveal how non-CpG methylation may contribute to Rett Syndrome

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Expanding research and clinical options for children with cancer

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