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FDA approves OLYSIO (simeprevir) for treatment of chronic hepatitis C infection

Janssen Therapeutics, Division of Janssen Products, LP, announced today the U.S. Food and Drug Administration has approved OLYSIO (simeprevir), an NS3/4A protease inhibitor, for the treatment of chronic hepatitis C infection as part of an antiviral treatment regimen in combination with pegylated interferon and ribavirin in genotype 1 infected adults with compensated liver disease, including cirrhosis.

23 Nov 2013

Targeting single enzyme in the obese could help prevent and treat diabetes

A single overactive enzyme worsens the two core defects of diabetes—impaired insulin sensitivity and overproduction of glucose—suggesting that a drug targeting the enzyme could help correct both at once, according to mouse studies done by researchers at Columbia University Medical Center. The findings were published today in the online edition of Cell Metabolism.

22 Nov 2013

Brown University biologists find way to measure effects of aging

Biologists at Brown University have found a way to measure the effects of aging by watching the ebb and flow of chromatin, a structure along strands of DNA that either silences or permits gene expression. In several newly published experiments they show that gene silencing via chromatin in fruit flies declines with age.

21 Nov 2013

Researchers discover new human enzyme that facilitates DNA repair during DNA copying process

Every day, the human body produces new cells to regenerate tissues and repair those that have suffered injury. Each time this happens, the cells make copies of their DNA that they will pass on to the resulting daughter cells. This process of copying the DNA, also called replication, is very delicate, given that it can generate severe alterations in the DNA that are associated with malignant transformation or ageing.

21 Nov 2013

UK's first gene therapy trial for patients with chronic heart failure begins at GJNH

The UK’s first gene therapy trial for advanced heart failure, CUPID 2, has officially begun at the Golden Jubilee National Hospital; with the first candidate recently being administered with a dose of the MYDICAR treatment.

21 Nov 2013

Staphylococcus Aureus Bacteria anticipates and turns immune defenses against the host

Around 20 percent of all humans are persistently colonized with Staphylococcus aureus bacteria, a leading cause of skin infections and one of the major sources of hospital-acquired infections, including the antibiotic-resistant strain MRSA.

20 Nov 2013

NeutroPhase irrigation therapy and NPWT help treat severe flesh eating and wound infections

NovaBay Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company developing topical non-antibiotic antimicrobial products, today announced the publication of a scientific paper by Dr. John R. Crew of Seton Medical Center, Daly City, California, describing the first use of adjunctive NeutroPhase irrigation therapy in conjunction with Negative Pressure Wound Therapy to successfully manage the severely-infected wound in the arm of a patient with life-threatening 'flesh-eating' disease.

20 Nov 2013

Researchers report long-term benefits of gene therapy in advanced heart failure patients

Researchers from the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai reported the long-term benefits of a single dose of their gene therapy AAV1/SERCA2a in advanced heart failure patients on Nov. 19 at the American Heart Association Scientific Sessions 2013.

20 Nov 2013

Weill Cornell Medical College receives grant to support research efforts designed to end women's cancers

MasterCard today announced a $500,000 grant to Weill Cornell Medical College to support research efforts designed to end women's cancers.

19 Nov 2013

Long-term use of PDE3 inhibitors can lead to increased risk for sudden cardiac death

Drugs known as PDE3 inhibitors save many lives by helping failing hearts do a better job of pumping blood. But those same medications come with a sometimes deadly cost when taken for long periods: an increased risk for sudden cardiac death.

19 Nov 2013

New hope for patients whose melanoma has metastasised to the brain

New data show that in patients whose melanoma (BRAF V600 mutation-positive) has spread (metastasised) to the brain, Zelboraf (vemurafenib) extends life expectancy by over six months compared to chemotherapy.1 These results are welcome news for patients suffering from metastatic melanoma, as up to half of these patients are diagnosed with brain metastases with many given less than six months to live.1

18 Nov 2013

Researchers explain new function of 2 key molecules involved in tumor progression

Researchers from IMIM (Hospital del Mar Medical Research Institute) lead by Dr. Sandra Peir- have described a new function for two key molecules involved in tumor progression.

16 Nov 2013

Early detection of breast cancer could soon be possible with blood test

What could someday be the first blood test for the early detection of breast cancer was shown in preliminary studies to successfully identify the presence of breast cancer cells from serum biomarkers, say the Houston Methodist Research Institute scientists who are developing the technology.

15 Nov 2013

Researchers use new approach to parse roles of key mutated protein that causes familial AD

Researchers at the University of California, San Diego School of Medicine have used genetic engineering of human induced pluripotent stem cells to specifically and precisely parse the roles of a key mutated protein in causing familial Alzheimer's disease, discovering that simple loss-of-function does not contribute to the inherited form of the neurodegenerative disorder.

15 Nov 2013

Copper intake via food and water can accelerate growth of tumors

Copper imbalances have been associated with a number of pathological conditions, including cancer. Publishing in PNAS scientists at EPFL have found that copper in drinking water - given at the maximum levels permitted in public water supplies - accelerated the growth of tumors in mice. On the other hand, reducing copper levels reduced tumor growth.

15 Nov 2013

Lower doses of antimalarial drug effective in reducing malaria transmission

Lower doses of the antimalarial drug primaquine are as effective as higher doses in reducing malaria transmission, according to a study published today in Lancet Infectious Diseases by London School of Hygiene & Tropical Medicine researchers.

15 Nov 2013

Medical researchers discover structure of potential drug target for rare genetic disease

Medical researchers at the University of Alberta have discovered the structure of a potential drug target for a rare genetic disease, paving the way for an alternative treatment for the condition.

15 Nov 2013

FDA approves ibrutinib for treatment of mantle cell lymphoma

Today's U.S. Food and Drug Administration approval of ibrutinib to treat patients with mantle cell lymphoma is a significant advance for patients with this blood cancer. It was approved as a single agent for treatment of patients with MCL who have received at least one prior therapy.

14 Nov 2013

Cardiologists question FDA recommendations on genetic testing before taking Plavix

Which antiplatelet medication is best after a coronary stent? The costly and potential life-or-death question lingers after most of the 600,000 angioplasties performed every year in the United States. The answer may lie in your genes, but professional cardiovascular societies and many working cardiologists question the U.S. Food and Drug Administration's recent recommendation that patients undergo genetic testing before taking Plavix (clopidogrel bisulfate).

14 Nov 2013

Mount Sinai researchers successfully test SUMO-1 gene therapy to reverse heart failure

Researchers at the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai have successfully tested a powerful gene therapy, delivered directly into the heart, to reverse heart failure in large animal models.

14 Nov 2013

Enzyme News and Research

FDA approves OLYSIO (simeprevir) for treatment of chronic hepatitis C infection

Targeting single enzyme in the obese could help prevent and treat diabetes

Brown University biologists find way to measure effects of aging

Researchers discover new human enzyme that facilitates DNA repair during DNA copying process

UK's first gene therapy trial for patients with chronic heart failure begins at GJNH

Staphylococcus Aureus Bacteria anticipates and turns immune defenses against the host

NeutroPhase irrigation therapy and NPWT help treat severe flesh eating and wound infections

Researchers report long-term benefits of gene therapy in advanced heart failure patients

Weill Cornell Medical College receives grant to support research efforts designed to end women's cancers

Long-term use of PDE3 inhibitors can lead to increased risk for sudden cardiac death

New hope for patients whose melanoma has metastasised to the brain

Researchers explain new function of 2 key molecules involved in tumor progression

Early detection of breast cancer could soon be possible with blood test

Researchers use new approach to parse roles of key mutated protein that causes familial AD

Copper intake via food and water can accelerate growth of tumors

Lower doses of antimalarial drug effective in reducing malaria transmission

Medical researchers discover structure of potential drug target for rare genetic disease

FDA approves ibrutinib for treatment of mantle cell lymphoma

Cardiologists question FDA recommendations on genetic testing before taking Plavix

Mount Sinai researchers successfully test SUMO-1 gene therapy to reverse heart failure

Biochemistry eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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