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Omeros files OMS824 IND with FDA to initiate clinical trials for cognitive disorders

Omeros Corporation today announced that it has filed an Investigational New Drug Application (IND) with the U.S. Food and Drug Administration (FDA) to initiate clinical trials evaluating OMS824, the Company's lead compound from its phosphodiesterase 10 (PDE10) program for schizophrenia and other cognitive disorders.

6 Sep 2012

Injecting capsule with heat-generating cells reduces abdominal and belly fat in mice

The injection of a tiny capsule containing heat-generating cells into the abdomens of mice led those animals to burn abdominal fat and initially lose about 20 percent of belly fat after 80 days of treatment.

6 Sep 2012

Eliminating jnk3 enzyme leads to 90% reduction in Alzheimer's plaque-forming compounds

Scientists have found that eliminating an enzyme from mice with symptoms of Alzheimer's disease leads to a 90 percent reduction in the compounds responsible for formation of the plaques linked to Alzheimer's disease.

6 Sep 2012

Study sheds light on why women gain fat following menopause

A high-fat diet triggers chemical reactions in female mice that could explain why women are more likely than men to gain fat in the abdomen after eating excess saturated fat, new research suggests. The study also sheds light on why women gain fat following menopause.

6 Sep 2012

TSC and PTEN genes important in controlling blood precursor cells in Drosophila

UCLA stem cell scientists have shown that two common tumor suppressor genes, TSC and PTEN, are vital to regulating the stem cell-like precursor cells that create the blood supply in Drosophila, the common fruit fly.

6 Sep 2012

Fusion-negative prostate tumours display more aberrant DNA methylations

In about half of all prostate tumours, there are two genetic areas that are fused with one another. When this is not the case, the exact way cancer cells originate in prostate tumours was not clear until now.

5 Sep 2012

FDA approves Bosulif to treat chronic myelogenous leukemia

The U.S. Food and Drug Administration today approved Bosulif (bosutinib) to treat chronic myelogenous leukemia (CML), a blood and bone marrow disease that usually affects older adults.

5 Sep 2012

Lack of evidence to recommend routine screening for chronic kidney disease

Currently there is insufficient evidence to recommend the routine screening of chronic kidney disease in asymptomatic adults in the general population, according to a review by the US Preventive Services Task Force.

4 Sep 2012

Coconut oil attacks tooth decay

Digested coconut oil could become part of the armory used to combat tooth decay, report researchers presenting their findings at the Society for General Microbiology’s Autumn Conference in Warwick, UK.

4 Sep 2012

Ultrastable RNA nanoparticles may help treat cancer and viral infections

A new study by University of Kentucky researchers shows promise for developing ultrastable RNA nanoparticles that may help treat cancer and viral infections by regulating cell function and binding to cancers without harming surrounding tissue.

4 Sep 2012

A-kinase anchoring proteins influence levels of glucose in the body

Scientists from the United States and Sweden have discovered a new control point that could be important as a drug target for the treatment of diabetes and other metabolic diseases.

4 Sep 2012

Diabetes prevention: an interview with Julian Baines, CEO of EKF Diagnostics

NICE public health guideline 38 ‘Preventing type 2 diabetes: Risk identification and interventions for individuals at high risk’.

From EKF Diagnostics 3 Sep 2012

DEAD-box proteins function as recycling nanopistons when unwinding RNA

AUSTIN, Texas-Molecular biologists at The University of Texas at Austin have solved one of the mysteries of how double-stranded RNA is remodeled inside cells in both their normal and disease states. The discovery may have implications for treating cancer and viruses in humans.

3 Sep 2012

Digested coconut oil able to attack the bacteria that cause tooth decay

Digested coconut oil is able to attack the bacteria that cause tooth decay. It is a natural antibiotic that could be incorporated into commercial dental care products, say scientists presenting their work at the Society for General Microbiology's Autumn Conference at the University of Warwick.

3 Sep 2012

NFAT protein plays a part in development of acute pancreatitis

It is likely that the protein is also highly significant for other inflammatory diseases. The research results have been published in the American journal Gastroenterology.

1 Sep 2012

Well-known protein plays central role in development of acute pancreatitis

There is now a clear target for the treatment of acute pancreatitis, according to researchers at Lund University in Sweden, who have discovered that a well-known protein plays a central role in the development of the disease. It is likely that the protein is also highly significant for other inflammatory diseases.

31 Aug 2012

Research identifies new pathway to target with anti-inflammatory drugs

Scientists' discovery of an important step in the body's process for healing wounds may lead to a new way of treating inflammation.

31 Aug 2012

Janssen submits bedaquiline MAA with EMA for treatment of multi-drug resistant tuberculosis

Janssen-Cilag International NV (Janssen) today announced it has submitted a Marketing Authorisation Application to the European Medicines Agency (EMA) seeking conditional approval for the use of the investigational drug bedaquiline (TMC207) as an oral treatment, to be used as part of combination therapy for pulmonary, multi-drug resistant tuberculosis (MDR-TB) in adults.

31 Aug 2012

Study explains how FPGS increases effectiveness of pemetrexed in mesothelioma patients

Previous studies have hypothesized that low levels of the enzyme thymidylate synthase (TS) likely mark patients who will benefit from the drug pemetrexed - but results have been inconclusive at best and at times contradictory. A University of Colorado Cancer Center study recently published in the Journal of Thoracic Oncology provides an explanation why: only in combination with high levels of a second enzyme, FPGS, does low TS predict response to pemetrexed in patients with malignant pleural mesothelioma.

31 Aug 2012

DNA synthesis in the 3’ and 5’ direction possible using new template-directed method

When a cell divides, it passes on genetic information by producing copies of its DNA. Chemists have also learned to copy DNA. In the journal Angewandte Chemie, a German team has now introduced a new copying technique that uses a single strand of DNA as the “master copy”, like a cell, but does not require enzymes.

30 Aug 2012