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The Lancet publishes phase 3 clinical study data on VIVITROL for treatment of opioid dependence

Alkermes, Inc. today announced that results from the phase 3 clinical study of VIVITROL® (naltrexone for extended-release injectable suspension) in opioid dependence have been published by The Lancet. The six-month, phase 3 trial met its primary endpoint and showed significantly greater opioid-free weeks among patients treated with VIVITROL, compared to placebo.

28 Apr 2011

Proteostasis acquires Harvard University's two novel protein target licenses

Proteostasis Therapeutics announced today that it has acquired two exclusive licenses from Harvard University to technologies for enhancing the activity of a key cellular protein clearance mechanism, the ubiquitin-proteasome pathway.

27 Apr 2011

Children, adolescents with liver disease may not benefit from vitamin E or metformin

In contrast to previous preliminary data, use of vitamin E or the diabetes drug metformin was not superior to placebo on a measured outcome for treating nonalcoholic fatty liver disease in children and adolescents, according to a study in the April 27 issue of JAMA.

27 Apr 2011

Heparan sulfate may have a key role in tumor-spurred lymphatic vessel growth

Cancer has a mighty big bag of tricks that it uses to evade the body's natural defense mechanisms and proliferate. Among those tricks is one that allows tumor cells to turn the intricate and extensive system of lymphatic vessels into something of a highway to metastasis. Yet research unveiled this week may aid in the development of therapeutics that will put the brakes on such cancer spread, and the researchers who completed the study say the findings may extend to other lymphatic disorders.

27 Apr 2011

FDA supports new Hepatitis C drug from Vertex Pharmaceuticals

Vertex pharmaceuticals jumped 10 percent in value on the Nasdaq after U.S. regulators FDA said the company’s experimental hepatitis C drug cures more patients than current therapies.

26 Apr 2011

New angle in cause of tuberculosis discovered - scientists hopeful for new therapy

In a new study published Monday, researchers from the US have isolated the enzyme that allows tuberculosis to destroy lung tissue. This discovery could speed the search for treatments.

26 Apr 2011

ACC/AHA release consensus document to help clinicians reduce risk of hypertension in older adults

Hypertension is very common among older adults. 64 percent of older men and 78 percent of older women have high blood pressure, placing them at heightened risk for heart disease including heart failure, stroke, coronary artery disease and atrial fibrillation, as well as chronic kidney disease and diabetes mellitus.

26 Apr 2011

Scientists identify key enzyme that destroys lung tissue in TB

Scientists have identified a key enzyme responsible for destroying lung tissue in tuberculosis, they report today in the Journal of Clinical Investigation. Drugs that inhibit this enzyme are already available, meaning that the finding could lead quickly to new treatments.

26 Apr 2011

Scientists develop new low cost test for acute pancreatitis

A new low cost test for acute pancreatitis that gets results much faster than existing tests has been developed by scientists at The University of Texas at Austin.

26 Apr 2011

Kadmon Pharmaceuticals and Nano Terra announce worldwide licensing agreement

Kadmon Pharmaceuticals LLC, and Nano Terra, Inc., today announced that they have entered into an agreement under which Kadmon has been granted a perpetual, worldwide exclusive license to three novel, clinical-stage product candidates owned by Nano Terra as well as rights to Nano Terra’s drug discovery platform, Pharmacomer™ Technology. The product candidates and technology platform will be transferred to a newly formed joint venture, NT Life Sciences (“NT Life”), co-owned by Kadmon and Nano Terra, which will act as the licensor and recipient of any licensing or royalty fees subject to the agreement. Terms of the agreement were not disclosed.

25 Apr 2011

Nano Terra, Kadmon sign deal to license novel product candidates

25 Apr 2011

Transplanting cells from healthy adult livers may help treat genetic liver-lung disorder

Transplanting cells from healthy adult livers may work in treating a genetic liver-lung disorder that affects millions of people worldwide, according to an animal study in the April 18 online edition of the Journal of Clinical Investigation.

22 Apr 2011

Daiichi Sankyo's LIXIANA receives Japanese marketing approval

Daiichi Sankyo Company, Limited, announced today that the company has received its first marketing approval for LIXIANA 15 mg and 30 mg tablets, by the Ministry of Health, Labor and Welfare in Japan.

22 Apr 2011

Research solves challenging problem of industry-scale production of large RNA molecules

Nanotechnology researchers have known for years that RNA, the cousin of DNA, is a promising tool for nanotherapy, in which therapeutic agents can be delivered inside the body via nanoparticles. But the difficulties of producing long-lasting, therapeutic RNA that remains stable and non-toxic while entering targeted cells have posed challenges for their progress.

22 Apr 2011

DNA rearrangements in roundworm chromosomes offer insight into genome duplications in developing tumors

A study of DNA rearrangements in roundworm chromosomes may offer new insight into large-scale genome duplications that occur in developing tumors.

22 Apr 2011

Scientists discover special mechanism that delays ageing

Animals that reproduce asexually by somatic cloning have special mechanisms that delay ageing provide exceptionally good health. Scientists at the University of Gothenburg have shown how colony-forming ascidians can activate the enzyme telomerase, which protects DNA. This enzyme is more active also in humans who attain an advanced age.

22 Apr 2011

Unanticipated structure at chromosome ends could be key ingredient in biological 'elixir of life'

In stark contrast to normal cells, which only divide a finite number of times before they enter into a permanent state of growth arrest or simply die, cancer cells never cease to proliferate. Now, scientists at the Salk Institute for Biological Studies have uncovered an important clue to one of the mechanisms underlying cancer cell immortality.

22 Apr 2011

Organophosphates exposure during pregnancy may impair child cognitive development

Researchers at Mount Sinai School of Medicine have found that exposure during pregnancy to a family of pesticides called organophosphates may impair child cognitive development. The findings are published online in Environmental Health Perspectives.

22 Apr 2011

Nature solves complex topological puzzles in DNA substrate recognition with elegant simplicity

A major discovery about an enzyme's structure has opened a window on understanding DNA repair. Scientists at Duke University Medical Center have determined the structure of a nuclease that will help scientists to understand several DNA repair pathways, a welcome development for cancer research.

21 Apr 2011

Discovery of cancer drugs to kill malaria parasite could open up new strategies for treatment

Ahead of World Malaria Day (25 April), EU-funded researchers have discovered that drugs originally designed to inhibit the growth of cancer cells can also kill the parasite that causes malaria. They believe this discovery could open up a new strategy for combating this deadly disease, which, according to World Health Organisation statistics, infected around 225 million and killed nearly 800 000 people worldwide in 2009.

21 Apr 2011

Enzyme News and Research

The Lancet publishes phase 3 clinical study data on VIVITROL for treatment of opioid dependence

Proteostasis acquires Harvard University's two novel protein target licenses

Children, adolescents with liver disease may not benefit from vitamin E or metformin

Heparan sulfate may have a key role in tumor-spurred lymphatic vessel growth

FDA supports new Hepatitis C drug from Vertex Pharmaceuticals

New angle in cause of tuberculosis discovered - scientists hopeful for new therapy

ACC/AHA release consensus document to help clinicians reduce risk of hypertension in older adults

Scientists identify key enzyme that destroys lung tissue in TB

Scientists develop new low cost test for acute pancreatitis

Kadmon Pharmaceuticals and Nano Terra announce worldwide licensing agreement

Nano Terra, Kadmon sign deal to license novel product candidates

Transplanting cells from healthy adult livers may help treat genetic liver-lung disorder

Daiichi Sankyo's LIXIANA receives Japanese marketing approval

Research solves challenging problem of industry-scale production of large RNA molecules

DNA rearrangements in roundworm chromosomes offer insight into genome duplications in developing tumors

Scientists discover special mechanism that delays ageing

Unanticipated structure at chromosome ends could be key ingredient in biological 'elixir of life'

Organophosphates exposure during pregnancy may impair child cognitive development

Nature solves complex topological puzzles in DNA substrate recognition with elegant simplicity

Discovery of cancer drugs to kill malaria parasite could open up new strategies for treatment

Biochemistry eBook

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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