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Discovery may lead to fast and cheap method of making vaccines

Researchers may be able to tinker with a single amino acid of an enzyme that helps viruses multiply to render them harmless, according to molecular biologists who say the discovery could pave the way for a fast and cheap method of making vaccines.

29 Aug 2007

Pfizer and Bristol-Myers Squibb finalize agreement on metabolic disorders program

Pfizer Inc. and Bristol-Myers Squibb Company have announced that they have finalized a definitive agreement for the worldwide collaboration to research, develop and commercialize DGAT-1 inhibitors, a collaboration first announced on April 26, 2007.

28 Aug 2007

Vioxx side-effects explained

Vioxx and related pain medications were taken off the market in 2004 because they caused dangerous heart problems in some people.

28 Aug 2007

Sildenafil increases release of key reproductive hormone oxytocin

Researchers at the University of Wisconsin-Madison report this month that sildenafil increases the amount of oxytocin released by stimulation of the posterior pituitary gland, a small structure directly underneath the brain that regulates hormone levels in response to neural signals.

24 Aug 2007

Binding up iron in the brain to combat Parkinson's and Alzheimer's

Duke University chemists are developing ways to bind up iron in the brain to combat the neurological devastation of Parkinson's and Alzheimer's diseases.

24 Aug 2007

Light may play a much more important role in bacterial life than has previously thought

The bacteria that cause brucellosis can sense light and use the information to regulate their virulence, according to a study in the August 24 issue of the journal Science.

24 Aug 2007

New clue to mechanisms of gene signaling and regulation

Scientists have discovered a pattern in the DNA sequence of the mouse genome that may play a fundamental part in the way DNA molecules regulate gene expression.

24 Aug 2007

Breakthrough for Huntington's disease

A major breakthrough in the understanding and potential treatment of Huntington's disease has been made by scientists at the University of Leeds.

24 Aug 2007

First finding of a metabolite in 1 sex only

Researchers at the University of Illinois at Chicago have discovered a chemical compound in male blue crabs that is not present in females -- the first time in any species that an entire enzyme system has been found to be activated in only one sex.

24 Aug 2007

Rapamycin study is first stage in development of new treatment

Rapamycin isn't your ordinary potential anti-cancer drug…It had a long and somewhat exotic history before undergoing preclinical (laboratory-based) studies at St. Jude as part of a national Pediatric Preclinical Testing Program (PPTP) investigation of its anticancer activity.

23 Aug 2007

Antitumour drugs impede DNA uncoiling by topoisomerase I

The annoying bulges of an overwound telephone cord that shorten its reach and limit a caller's motion help explain why drugs called camptothecins are so effective in killing cancer cells, according to investigators led by Mary-Ann Bjornsti, Ph.D., at St. Jude Children’s Research Hospital, and Nynke Dekker, Ph.D., at Delft Technology University.

22 Aug 2007

Pomegranate juice does not impair clearance of oral or intravenous Midazolam

A study from the Tufts University School of Medicine published in the Journal of Clinical Pharmacology finds that pomegranate juice does not interact with oral or intravenous medication, contrary to previous information.

22 Aug 2007

Natural antimicrobial agents for food safety

Two items high on the list of public concerns are the need for greater food safety and a growing demand for natural or organic food products.

22 Aug 2007

Traffic and childhood asthma

Children who carry variations in specific genes that metabolize vehicle emissions are more susceptible to developing asthma, particularly if they live near major roadways, a study led by researchers at the University of Southern California (USC) suggests.

22 Aug 2007

Exhaust fumes increase risk for asthma in genetically susceptible children

Exhaust fumes heighten the risk of asthma in children who are already genetically susceptible to respiratory disease, indicates research published ahead of print in the journal Thorax.

22 Aug 2007

New Cockayne syndrome discovery

Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have shown that the genetic defect that causes Cockayne Syndrome affects a key function of the cell – the transcription of genes coding for ribosomal RNA.

21 Aug 2007

Tumors use enzyme to recruit regulatory T-cells and suppress immune response

One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, researchers say.

17 Aug 2007

We need to treat cancer like an infectious disease

Among the many medical miracles produced by science over the years, vaccines and antibiotics have undoubtedly saved the most lives.

17 Aug 2007

Cannabis for allergic contact dermatitis

Administering a substance found in the cannabis plant can help the body's natural protective system alleviate an allergic skin disease (allergic contact dermatitis), an international group of researchers from Germany, Israel, Italy, Switzerland and the U.S. has found.

17 Aug 2007