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Promising new tuberculosis drug enters clinical trial

A promising new drug candidate that may be effective against both actively dividing and slow-growing Mycobacterium tuberculosis (M. tb) has begun testing in humans, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, announced this week.

15 Jun 2005

Arteries bio-engineered from elderly cells

Researchers from Duke University's Medical Center and Pratt School of Engineering have demonstrated that they can grow new human blood vessels from cells taken from patients who especially need such assistance – older adults with cardiovascular disease.

14 Jun 2005

Study examines biomarkers for response to erlotinib in glioma

Researchers have found two biomarkers that, in patients with a malignant type of brain tumor called glioblastoma multiforme, were associated with response to the cancer drug erlotinib (Tarceva).

14 Jun 2005

Orlistat, a drug that decreases fat absorption, appears helpful for improving weight management in obese adolescents

When combined with diet, exercise and behavioral therapy, orlistat, a drug that decreases fat absorption, appears helpful for improving weight management in obese adolescents, compared with placebo, according to an article in the June 15 issue of JAMA: The Journal of the American Medical Association.

14 Jun 2005

Ruboxistaurin shows favorable effects on kidney damage and function in people with type 2 diabetes and nephropathy

Eli Lilly and Company today announced encouraging results from a one-year pilot study examining the effect of ruboxistaurin mesylate in persons with type 2 diabetes and kidney disease (also known as "diabetic nephropathy").

12 Jun 2005

Researchers discover how microRNA are involved in the development of heart muscle

Researchers at UT Southwestern Medical Center have discovered how a small molecule of RNA called microRNA - a chemical cousin of DNA - helps fine tune the production of a key protein involved in the early development of heart muscle.

12 Jun 2005

Bio-engineered skin provides clues to melanoma development

When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard Hughes Medical Institute predoctoral fellow at Stanford University School of Medicine.

12 Jun 2005

Link between PKC enzyme and kidney disease in diabetes confirmed

Researchers at Joslin Diabetes Center have investigated PKC-beta - a critical enzyme implicated in the devastating complications of type 1 and type 2 diabetes - for more than two decades.

12 Jun 2005

Link between hyperglycemia (high blood glucose), overexpression of PKC-beta 2 and kidney disease

Scientists at Joslin Diabetes Center have investigated PKC-beta -- a critical enzyme implicated in the devastating complications of type 1 and type 2 diabetes -- for more than two decades.

10 Jun 2005

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

Using targeted RNA interference, or RNAi libraries, researchers at Harvard Medical School describe the first large-scale classification of kinase and phosphatase gene families on the basis of their role in apoptosis and cell survival. This study appears in the June issue of Nature Cell Biology.

10 Jun 2005

New start-up to market test that predicts heart attack risk

PrognostiX, a start-up company based on Cleveland Clinic technology, has received approval from the U.S. Food and Drug Administration to begin selling a diagnostic test capable of identifying patients who are in imminent danger of heart attack or death.

9 Jun 2005

Designed drug for combined hormone and chemotherapy treatment

The search for new drugs to fight cancer remains at the top of the to do list for pharmaceutical researchers. A recent variation is polymer chemotherapy agents, drugs that have been attached to a "backbone" of long chain molecules.

9 Jun 2005

Prototype drug shows promise in slowing replication of the virus responsible for SARS

A prototype drug created by researchers at the University of Illinois at Chicago shows promise in slowing replication of the virus responsible for severe acute respiratory syndrome, or SARS.

8 Jun 2005

6 minutes exercise a week is all you need to keep fit!

In news that will hearten the souls of all those couch potatoes out there, new research has shown that keeping fit and healthy may only require minutes of physical exercise each week.

7 Jun 2005

New series of human drug targets available to all researchers

The Structural Genomics Consortium (SGC), an Anglo-Canadian charitable consortium of public and private agencies including Oxford University, announced recently that it has delivered its first 50 human and malaria protein structures into the public domain on budget and two months ahead of schedule.

6 Jun 2005

Helmholtz Institute develops a new path to more effective antibiotics

Resistance to antibiotics has increased alarmingly in recent years. For example, in France the resistance of pneumococci has risen to 58% due to high rates of antibiotic prescription. Medical experts are sounding the alarm. Pharmacologists are seeking new antibiotically effective substances.

6 Jun 2005

Researchers successfully image delivery and gene expression of DNA nanoparticles into lungs of CF mice

Researchers at the American Society of Gene Therapy Meeting in St. Louis announced that by using imaging technologies, they are able to successfully trace the delivery of DNA nanoparticles and the extent of gene transfer in the lungs of cystic fibrosis (CF) animals.

6 Jun 2005

Genetics may play a role in the effectiveness of chemotherapy drugs

Today, the most common childhood cancer is cured in about 80 percent of patients; only forty years ago, this number was closer to five percent. In efforts to further increase the survival rate, researchers from St. Jude Children's Research Hospital, the University of Tennessee, and the University of Chicago studied how an individual's genetics might play a role in the effectiveness of chemotherapy drugs.

3 Jun 2005

Research findings suggest new treatment strategies for patients with cystic fibrosis

Cells sent to fight infections in the lungs of cystic fibrosis patients actually enhance the development of permanent bacterial infections, according to researchers at National Jewish Medical and Research Center.

3 Jun 2005

Research explains why Shigella and E. coli are rapidly becoming resistant to fluoroquinolones

Scientists at the Albert Einstein College of Medicine have discovered a novel strategy by which the bacterium that causes tuberculosis may soon be able to resist the effects of antibiotics known as fluoroquinolones.

3 Jun 2005

Enzyme News and Research

Promising new tuberculosis drug enters clinical trial

Arteries bio-engineered from elderly cells

Study examines biomarkers for response to erlotinib in glioma

Orlistat, a drug that decreases fat absorption, appears helpful for improving weight management in obese adolescents

Ruboxistaurin shows favorable effects on kidney damage and function in people with type 2 diabetes and nephropathy

Researchers discover how microRNA are involved in the development of heart muscle

Bio-engineered skin provides clues to melanoma development

Link between PKC enzyme and kidney disease in diabetes confirmed

Link between hyperglycemia (high blood glucose), overexpression of PKC-beta 2 and kidney disease

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

New start-up to market test that predicts heart attack risk

Designed drug for combined hormone and chemotherapy treatment

Prototype drug shows promise in slowing replication of the virus responsible for SARS

6 minutes exercise a week is all you need to keep fit!

New series of human drug targets available to all researchers

Helmholtz Institute develops a new path to more effective antibiotics

Researchers successfully image delivery and gene expression of DNA nanoparticles into lungs of CF mice

Genetics may play a role in the effectiveness of chemotherapy drugs

Research findings suggest new treatment strategies for patients with cystic fibrosis

Research explains why Shigella and E. coli are rapidly becoming resistant to fluoroquinolones

Biochemistry eBook

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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