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Compound derived from fruit and vegetables could be used to improve the effects of an established cancer drug

The drug, mitomycin C (MMC), is a well-known anticancer treatment used mainly against solid tumours in the bladder and lower bowel. It is activated by enzymes naturally found in the human body, but its use is limited by severe side effects at higher doses.

5 Oct 2004

Scientists have shown that the textbook explanation of how enzymes work is wrong

Their discovery may explain why attempts to make artificial enzymes have often been disappointing. Industry must now re-think the rationale for the design of biological catalysts and its approaches to drug design.

5 Oct 2004

Novel compound that resembles vitamin E halves the size of tumors and the ability of cancer to spread

By studying cancer in mice, researchers at The University of Texas at Austin have gained preliminary evidence that a novel compound that resembles vitamin E halves the size of tumors and the ability of cancer to spread to other body sites.

30 Sep 2004

Berkeley searches for AIDS cure in a Samoan indigenous tree

The University of California, Berkeley, has signed an agreement with the Samoan government to isolate from an indigenous tree the gene for a promising anti-AIDS drug and to share any royalties from sale of a gene-derived drug with the people of Samoa.

30 Sep 2004

Research confirms benefits of commonly used traditional remedies for a range of illnesses

Research presented to the British Pharmaceutical Conference today, confirms the benefits of commonly used traditional remedies for a range of illnesses, including cancer, offering a scientific justification for their use.

29 Sep 2004

Trial shows which brain cancer patients benefit from temozolomide

An international team of scientists and cancer specialists has identified which patients with the deadly form of brain tumours called glioblastomas are likely to live longer if they are treated with temozolomide, and which patients are likely to get only marginal, if any, benefit.

28 Sep 2004

New hope for patients suffering hormone therapy resitant prostate cancer

New hope was offered today to men with advanced prostate cancer that no longer responds to hormone therapy – a persistent problem in prostate cancer treatment.

27 Sep 2004

Active ingredients of soya may help beat breast cancer

Researchers are investigating whether it is possible to turn the active ingredients of soya into a useful medicine that may help to beat breast cancer, the British Pharmaceutical Conference heard today.

27 Sep 2004

Research shows specific damage to nervous system in veterans with Gulf War syndrome

UT Southwestern researchers report that damage to the parasympathetic nervous system may account for nearly half of the typical symptoms - including gallbladder disease, unrefreshing sleep, depression, joint pain, chronic diarrhea and sexual dysfunction - that afflict those with Gulf War syndrome. Their findings will be published in the October issue of the American Journal of Medicine and are currently available online.

27 Sep 2004

Discovery of key molecular step which allows cancer cells to move to different parts of the body

Researchers at The University of Texas M. D. Anderson Cancer Center have figured out a key molecular step by which a cancer cell can unhook itself from the mesh weave of other cancer cells in a tumor, and move away to a different part of the body - the process, known as metastasis, that makes cancer so dangerous.

27 Sep 2004

Study is the first to show that lowering the levels of lipid in nerve terminals affects the efficiency of neurotransmission

Yale researchers demonstrate the crucial role of a membrane lipid called phosphatidylinositol-4,5-bisphosphate (PtdIns (4,5)P2) in the communication of information between synapses in the brain, according to a study published this week in Nature.

26 Sep 2004

Discovery of how protein in teeth controls bone-like crystals to form steely enamel

Bone and enamel start with the same calcium-phosphate crystal building material but end up quite different in structure and physical properties.

26 Sep 2004

Low-dose infusion of ketamine completely relieves pain of complex regional pain syndrome

Limited, low-dose infusions of a widely used anesthetic drug may relieve the often intolerable and debilitating pain of Complex Regional Pain Syndrome (CRPS), a Penn State Milton S. Hershey Medical Center researcher found.

23 Sep 2004

New combination of drugs results in fewer incidences of rejection in liver transplant patients

“The big advantage [of this combination of drugs] is that the incidence of rejection is significantly decreased,” he says. “These results could change the standard of care for liver transplant recipients.”

23 Sep 2004

Four or more glasses of red wine per week may reduce risk of prostate cancer by 50 percent

Drinking a glass of red wine a day may cut a man's risk of prostate cancer in half, and the protective effect appears to be strongest against the most aggressive forms of the disease

23 Sep 2004

Fish oils appear to reduce breast cancer risk

Researchers who found that fish oils appear to reduce breast cancer risk have now discovered that the oils may especially benefit women with particular genetic makeups.

21 Sep 2004

New gene therapy technique may help treat Alzheimer's disease

Investigators at Rush University Medical Center have successfully initiated a new technique that uses gene therapy to deliver nerve growth factor into regions of the brain where neurons are degenerating, in order to prevent cell death and reverse cell atrophy, two hallmarks of Alzheimer's disease.

21 Sep 2004

New anti-inflammatory strategy for cancer therapy

A new strategy for cancer therapy, which converts the tumor-promoting effect of the immune system’s inflammatory response into a cancer-killing outcome, is suggested in research findings by investigators at the University of California, San Diego (UCSD) School of Medicine.

20 Sep 2004

New Australian biotech speeds up healing for burns and wounds

A Queensland PhD student’s discovery speeds up tissue growth and repair and sparks off a new listed biotech company.

20 Sep 2004

Resveratrol in red wine, is thought to contribute to improved cardiovascular effects associated with moderate consumption of red wine

Researchers funded by the National Science Foundation (NSF) and affiliated with the Salk Institute in San Diego, Calif., have succeeded in converting chalcone synthase, a biosynthetic protein enzyme found in all higher plants, into an efficient resveratrol synthase.

20 Sep 2004

Enzyme News and Research

Compound derived from fruit and vegetables could be used to improve the effects of an established cancer drug

Scientists have shown that the textbook explanation of how enzymes work is wrong

Novel compound that resembles vitamin E halves the size of tumors and the ability of cancer to spread

Berkeley searches for AIDS cure in a Samoan indigenous tree

Research confirms benefits of commonly used traditional remedies for a range of illnesses

Trial shows which brain cancer patients benefit from temozolomide

New hope for patients suffering hormone therapy resitant prostate cancer

Active ingredients of soya may help beat breast cancer

Research shows specific damage to nervous system in veterans with Gulf War syndrome

Discovery of key molecular step which allows cancer cells to move to different parts of the body

Study is the first to show that lowering the levels of lipid in nerve terminals affects the efficiency of neurotransmission

Discovery of how protein in teeth controls bone-like crystals to form steely enamel

Low-dose infusion of ketamine completely relieves pain of complex regional pain syndrome

New combination of drugs results in fewer incidences of rejection in liver transplant patients

Four or more glasses of red wine per week may reduce risk of prostate cancer by 50 percent

Fish oils appear to reduce breast cancer risk

New gene therapy technique may help treat Alzheimer's disease

New anti-inflammatory strategy for cancer therapy

New Australian biotech speeds up healing for burns and wounds

Resveratrol in red wine, is thought to contribute to improved cardiovascular effects associated with moderate consumption of red wine

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