Ferroptosis News and Research

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Ferroptosis regulation of GLS2 as a potential therapeutic strategy against liver diseases

A new editorial paper was published in Oncotarget's Volume 14 on October 19, 2023, entitled, "GLS2 shapes ferroptosis in hepatocellular carcinoma."

19 Oct 2023

Evidence reveals ferroptosis's critical role in male reproductive health

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2 Oct 2023

Researchers identify key mechanisms to address future treatments for hereditary blindness

There are still many enigmas about the mechanism of action of the CERKL gene, which causes retinitis pigmentosa and other hereditary vision diseases.

18 Sep 2023

OHSU scientists discover new avenue of cell death in Alzheimer's disease and vascular dementia

Researchers have discovered a new avenue of cell death in Alzheimer's disease and vascular dementia.

5 Sep 2023

The potential of targeting mitochondria-associated programmed cell death for age-related disease treatment

The review summarized the involvement of mitochondria in age-related disease progression and highlighted its potential as a therapeutic target of these diseases.

28 Aug 2023

Researchers uncover the role of glutaminase 2 in glucose homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

5 Jul 2023

Novel anti-cancer drug found to sensitize tumor cells to ferroptosis

A team of researchers led by Dr. Marcus Conrad from Helmholtz Munich discovered a novel anti-cancer drug, called icFSP1, which sensitizes cancer cells to ferroptosis.

28 Jun 2023

Pyroptosis: A potential therapeutic target for lung cancer

Lung cancer, one of the most aggressive forms of cancer, continues to be a leading cause of death worldwide. Although several new therapies have been developed for this disease, it has a poor prognosis in its advanced stages.

28 Jun 2023

Analyzing the role of ACSL4 in quadruple negative breast cancer

A new review paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "ACSL4: biomarker, mediator and target in quadruple negative breast cancer."

15 Jun 2023

Novel imaging method shows link between iron redox and Alzheimer’s disease

There is a growing body of evidence that iron in the brain may play a role in Alzheimer's disease. Lending weight to that idea, a new imaging probe has for the first time shown that in the same regions of the brain where the amyloid beta plaques associated with Alzheimer's occur, there is also an increase in iron redox, meaning the iron in these regions is more reactive in the presence of oxygen.

19 Apr 2023

Early-life gut microbial dysbiosis exacerbates colitis

A recent Research journal study investigated the role of microbiota linked to the anaerobic plasmalogen biosynthetic pathway in establishing intestinal homeostasis. The study hypothesized that the presence of pls [PlsA/R]-positive bacterial species and plasmalogen bestow valuable intestine homeostasis in early life.

13 Apr 2023

Unexpected discovery could inspire new strategies for preventing liver disease and cancer

Liver cancer is the third leading cause of cancer death and the sixth most common cancer type worldwide.

12 Apr 2023

Leveraging cell self-destruction to treat glioblastoma tumors

Glioblastoma is the most common type of brain tumor in adults. The disease is 100% fatal and there are no cures, making it the most aggressive type of cancer. Such a poor prognosis has motivated researchers and neurosurgeons to understand the biology of tumors with the goal of creating better therapies.

7 Apr 2023

Scientists unearth some of the biological mechanisms behind ferroptosis

A team of researchers at Tohoku University has unearthed some of the biological mechanisms of ferroptosis, a recently discovered type of regulated cell death that is triggered by iron and the accumulation of lipid peroxidation - lipids that have undergone oxidative degeneration.

5 Apr 2023

Cuproptosis-associated ferroptosis genes linked with immune infiltration in atherosclerosis

Announcing a new article publication for Cardiovascular Innovations and Applications journal. In this study, the authors identify cuproptosis-associated ferroptosis genes in the atherosclerosis microarray of the Gene Expression Omnibus (GEO) database and explored hub gene-mediated immune infiltration in atherosclerosis.

15 Mar 2023

Ferroptosis could be the key to making effective immunotherapies against liver cancer

Iron-dependent cell death (ferroptosis) is a type of programmed cell death by means of which the body kills off diseased, defective or superfluous cells.

17 Feb 2023

Canagliflozin ameliorates heart function in HFpEF rats partly by regulating ferroptosis

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been found to ameliorate major adverse cardiovascular events in patients with heart failure with preserved ejection fraction (HFpEF), but the exact mechanism is unknown.

17 Feb 2023

Study reveals mechanism of a previously unexplained type of cell death

A study from researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Cell Biology, details a previously unexplained type of cell death called disulfidptosis that could open the door for novel cancer therapeutic strategies.

6 Feb 2023

Female resilience to cell death could be therapeutically harnessed to improve kidney repair

In the battle of the sexes, women beat men in their ability to recover from kidney injury, but the reasons are not well understood.

8 Nov 2022

Selectively targeting iGPX4 may be a promising therapeutic strategy for metabolic-associated fatty liver disease

This new article publication from Acta Pharmaceutica Sinica B, discusses targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease.

26 Sep 2022