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Biomimetic amplification of nanoparticle homing to tumors

A collaborative, multidisciplinary team of researchers has created nanoparticles that act much like a developing clot to target tumors.

16 Jan 2007

Test to detect drug-resistant HIV strains could help provide earlier treatment

A test to detect drug-resistant HIV strains in people with low levels of drug-resistant viral loads could help physicians provide more effective treatment earlier to HIV-positive people, according to a study published on Sunday in the online edition of the journal Nature Methods, BBC News reports.

9 Jan 2007

Dark state and DNA

Chemists at Ohio State University have probed an unusual high-energy state produced in single nucleotides - the building blocks of DNA and RNA - when they absorb ultraviolet (UV) light.

9 Jan 2007

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

By combining a quantum dot with a novel carrier of the magnetic resonance imaging (MRI) agent gadolinium, a team of investigators at the University of Maastricht, in The Netherlands, has developed a nanoparticle that can spot apoptosis, or programmed cell death, using both MRI and fluorescence imaging.

8 Jan 2007

In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles

In an attempt to determine what factors make one nanoparticle better than another at targeting tumors, a team of investigators in Korea have conducted a systematic tumor-targeting study of a variety of self-assembling nanoparticles.

18 Dec 2006

Aptamer-capped nanocrystal quantum dots

Quantum dots, used increasingly as bright fluorescent markers in basic research and diagnostic assays, must be coated, or capped, with one of a wide variety of organic molecules in order to stabilize these nanocrystals and prevent them from aggregating when added to water.

18 Dec 2006

Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence

In the first experiments of their kind, researchers have determined that carbon nanotubes injected directly into the bloodstream of research lab animals cause no immediate adverse health effects and circulate for more than one hour before they are removed by the liver.

18 Dec 2006

Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma

Nanoscale, inorganic fluorescent imaging agents such as quantum dots have become an important tool for researchers studying key biomolecules involved in cancer.

18 Dec 2006

Biofunctional organic nanocrystals for quantitative detection of pathogen deoxyribonucleic acid

Waiting a day or more to get lab results back from the doctor's office soon could become a thing of a past.

4 Dec 2006

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

In attempt to identify biological markers, or biomarkers, that can signal the presence of cancer and help oncologists determine the best course of therapy when cancer is present, teams of investigators are scouring stored tissue samples obtained from thousands of cancer patients.

4 Dec 2006

Nanotechnology continues to advance anticancer gene therapy

Given that cancer is a disease in which genetic errors play a major role, it should come as no surprise that many experts envision a time when gene therapy will play an equally important role in the treatment of cancer.

20 Nov 2006

Low-field magnetic separation of monodisperse Fe3O4 nanocrystals

Whether the goal is to separate different types of cells or molecules, methods that rely on the age-old principle of magnetism are a staple among researchers.

20 Nov 2006

Templated self-assembly of quantum dots from aqueous solution using protein scaffolds

Quantum dots are rapidly becoming biomedical researchers' tool of choice for adding a fluorescent label to a wide variety of biomolecules.

20 Nov 2006

MChip to detect H5N1

Scientists from the University of Colorado at Boulder and the Centers for Disease Control and Prevention (CDC) have developed an inexpensive "gene chip" test based on a single influenza virus gene that could allow scientists to quickly identify flu viruses, including avian influenza H5N1.

14 Nov 2006

Modified silicon-based surfaces provide good home to proteins

Silicon, whether in its elemental form as silicon wafers or in its oxidized form, known as silicon dioxide or silica, is proving to be a valuable material for biomedical nanotechnology, in large part because of the biocompatibility and chemical inertness of these substances.

13 Nov 2006

Multifunctional composite nanoparticles: magnetic, luminescent, and mesoporous

Silica, the mineral of which sand is made, is generally inert in the body and can be modified easily using a variety of well-established chemical reactions.

30 Oct 2006

Self-assembling nanoparticle releases drug into cell cytoplasm

A growing body of research leaves no doubt that nanoparticles can transport drugs into cancer cells, but what is less clear is that the drug payload can exit the tiny endosomes that pull nanoparticles into cells.

30 Oct 2006

Researchers identify peptide that spurs cargo transport in nerve cells

For the first time, researchers have identified a peptide that can spur cargo transport in nerve cells, a discovery that could help scientists better understand nerve cell function and test possible therapies for neurodegenerative diseases.

24 Oct 2006

Scientists explain how transport proteins can move in cells without bumping into or sticking to anything

Scientists from the Max Planck Institute for Molecular Cell Biology and Genetics (MPI-CBG) in Dresden, along with a colleague from the University of Florida in the United States, have been carrying out research into how transport proteins can move in cells without bumping into or sticking to anything.

24 Oct 2006

Quantum dots help cancer imaging studies

One of the more difficult diagnostic tasks an oncologist faces is determining if cancer has spread to the lymphatic system, particularly when it is necessary to assess lymphatic drainage from two separate drainage basins.

23 Oct 2006

Fluorescence News and Research

Biomimetic amplification of nanoparticle homing to tumors

Test to detect drug-resistant HIV strains could help provide earlier treatment

Dark state and DNA

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles

Aptamer-capped nanocrystal quantum dots

Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence

Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma

Biofunctional organic nanocrystals for quantitative detection of pathogen deoxyribonucleic acid

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

Nanotechnology continues to advance anticancer gene therapy

Low-field magnetic separation of monodisperse Fe3O4 nanocrystals

Templated self-assembly of quantum dots from aqueous solution using protein scaffolds

MChip to detect H5N1

Modified silicon-based surfaces provide good home to proteins

Multifunctional composite nanoparticles: magnetic, luminescent, and mesoporous

Self-assembling nanoparticle releases drug into cell cytoplasm

Researchers identify peptide that spurs cargo transport in nerve cells

Scientists explain how transport proteins can move in cells without bumping into or sticking to anything

Quantum dots help cancer imaging studies

Fluorescence eBook

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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