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Research sheds light on molecular movements of neural transporters

A team of scientists from Columbia University College of Physicians and Surgeons and Weill Cornell Medical College has shed light on the molecular workings of transporter proteins, molecular machines embedded in the cell membranes of neurons that modulate the transfer of signals between cells and recycle neurotransmitters.

25 Apr 2011

Contrast agent for tumor diagnostics

X-rays are not the only way: visible and especially infrared light can also be used to image human tissue. The effectiveness of optical imaging processes can be significantly improved with suitable dyes used as contrast agents. In the journal Angewandte Chemie, a team led by Wenbin Lin at the University of North Carolina (Chapel Hill, USA) has now introduced a novel contrast agent that marks tumor cells in vitro. The dye is a phosphorescent ruthenium complex incorporated into nanoparticles of a metal–organic coordination polymer, which allows an extraordinarily high level of dye loading.

23 Mar 2011

Laser light can kill cancer cells by pumping drugs into them

Shining a laser light on cells and then clicking off the light makes the cells "breathe in" surrounding water, providing a potentially powerful delivery system for chemotherapy drugs, as well as a non-invasive way to target anti-Alzheimer's medicines to the brain. That's the conclusion of a report in ACS's The Journal of Physical Chemistry Letters.

17 Mar 2011

BD announces addition of new flow cytometry system for rapid microbial enumeration, detection

Industrial microbiologists now have a new tool that was designed specifically to help quality control laboratories rapidly screen raw materials, as well as in-process and finished goods, for the presence of microorganisms that can threaten product quality.

17 Feb 2011

Study unveils surprising mechanism that controls brain formation

A study from The Scripps Research Institute has unveiled a surprising mechanism that controls brain formation. The findings have implications for understanding a host of diseases, including some forms of mental retardation, epilepsy, schizophrenia, and autism.

10 Feb 2011

Single molecule FRET techniques combined with wavelet transforms give new view of AMPA receptor

A digital signal processing technique long used by statisticians to analyze data is helping Houston scientists understand the roots of memory and learning, Alzheimer's and Parkinson's diseases and stroke.

8 Feb 2011

TREK1 activity offers a key target for fluoxetine and other antidepressant drugs

Using a unique and relatively simple cell-based fluorescent assay they developed, scientists with the U.S. Department of Energy's Lawrence Berkeley National Laboratory and the University of California, Berkeley have identified a means by which fluoxetine, the active ingredient in Prozac, suppresses the activity of the TREK1 potassium channel.

8 Feb 2011

UCLA imaging system could help reveal 'miscommunications' in autism, schizophrenia

Some disorders of the brain are obvious - the massive death of brain cells after a stroke, the explosion in the growth of cells that marks a tumor. Other disorders, such as autism, schizophrenia and mental retardation show no physical signs of damage and are believed to be caused by problems in how brain cells communicate with one another.

13 Jan 2011

All fat cells not the same

All fat cells are not the same - a fact that has implications in the understanding and treatment of type 2 diabetes and obesity, said researchers from Baylor College of Medicine (www.bcm.edu) in a report that appears in the current issue of the Journal of Cell Biology (http://www.jcb.rupress.org/).

10 Jan 2011

Virus fighting just got a new boost

In a ground breaking study in the UK researchers have identified a previously unknown mechanism that allows the immune system to fight viruses even after they have infected cells. Until now it was believed that antibodies can act only before the virus enters the cells. The team now has found that antibodies that attached themselves to a virus were able to follow it into cells and help to destroy the virus before it started to reproduce. This could open up new avenues of therapy.

2 Nov 2010

NIH awards $1.2 million EUREKA grant to study protein misfolding

Three University of Massachusetts Amherst scientists have received a four-year, $1.2 million EUREKA grant from the U.S. National Institutes of Health (NIH) to study folding and misfolding of secretory proteins in the cell's protein factory, the endoplasmic reticulum, where misfolding can lead to diseases such as cystic fibrosis and liver cirrhosis.

3 Sep 2010

Researchers develop high-resolution technology to visualize individual virus particles

In the war against infectious disease, identifying the culprit is half the battle. Now, research professor Shaopeng Wang and his colleagues from the Biodesign Institute at Arizona State University, describe a new method for visualizing individual virus particles. Their research opens the door to a more detailed understanding of these minute pathogens, and may further the study of a broad range of micro- and nanoscale phenomena.

25 Aug 2010

Replacing hydrogen with deuterium increases stability, shelf life of fluorescent probes: Research

By swapping out one specific hydrogen atom for an isotope twice as heavy, researchers have increased the shelf life and detection ability of fluorescent probes that are essential to studying a variety of inflammatory diseases, including cancer and atherosclerosis. The probes detect and measure reactive oxygen species, which play an important role in disease processes.

21 Jul 2010

Innovative imaging system uses night vision technology to tackle common side effect of cancer treatment

The University of Texas Health Science Center at Houston (UTHealth) has reached an agreement with other institutions that will allow it to take the next step in commercially developing an innovative medical imaging system that uses night vision technology to tackle a common side effect of cancer treatment.

16 Jul 2010

Novel imaging agents and techniques can revolutionize medical imaging science: JNM

A study published in the July issue of The Journal of Nuclear Medicine (JNM) reports on investigative research of a novel optical imaging technique called "Cerenkov luminescence imaging (CLI)." According to the authors, the technique could lead to the faster and more cost-effective development of radiopharmaceuticals for the diagnosis and treatment of cancer and other conditions.

2 Jul 2010

Consumer-grade camera detects cancer cells in real time

Using an off-the-shelf digital camera, Rice University biomedical engineers and researchers from the University of Texas M.D. Anderson Cancer Center have created an inexpensive device that is powerful enough to let doctors easily distinguish cancerous cells from healthy cells simply by viewing the LCD monitor on the back of the camera.

From Evident Corporation - Life Sciences 25 Jun 2010

New medical imaging technique using pulsed laser and nanocages

New research findings suggest that an experimental ultrasensitive medical imaging technique that uses a pulsed laser and tiny metallic "nanocages" might enable both the early detection and treatment of disease.

13 Apr 2010

Glycolytic oscillations during ischemia can increase heart damage

Researchers in Germany show that a classical biological oscillator, the glycolytic oscillator, may increase damage to the heart during acute loss of oxygen (anoxia), and as may occur during ischemia.

16 Mar 2010

VisEn Medical introduces VivoTag 680 XL fluorescent dye for labeling biomolecules

VisEn Medical Inc., a leader in fluorescence in vivo imaging from research through medicine, announced today the commercial launch of its new VivoTag® 680 XL fluorescent dye for labeling biomolecules in a broad range of in vitro and in vivo imaging applications.

12 Mar 2010

Life Technologies to acquire AcroMetrix

Life Technologies Corporation, a provider of innovative life science solutions, today announced that it has signed a definitive agreement to acquire AcroMetrix, for an undisclosed amount.

12 Jan 2010