Gadolinium News and Research

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Targeted nanoparticles map tumor blood supply in 3-D, assess therapy

One of the defining characteristics of solid tumors is the development of a network of new blood vessels to nourish the rapidly reproducing malignant cells. Now, using a nanoparticle targeted to those new blood vessels, a joint academic-industrial research team, led by investigators from the Siteman Center of Cancer Nanotechnology Excellence, has developed a way to construct a three-dimensional (3-D) map of tumor-induced angiogenesis and monitor the effects of drug therapies on those new blood vessels.

28 Sep 2008

Ultra-miniature bialy-shaped drug delivery particles

Ultra-miniature bialy-shaped particles - called nanobialys because they resemble tiny versions of the flat, onion-topped rolls popular in New York City - could soon be carrying medicinal compounds through patients' bloodstreams to tumors or atherosclerotic plaques.

29 Jul 2008

Holey nanoparticles create new tumor imaging and therapeutic agent

Using a polymer that has both water-soluble and water-insoluble regions, a team of investigators from the Siteman Center of Cancer Nanotechnology Excellence has created a nanoparticle shaped like a bialy, a close relative of the bagel. Combining this nanoparticle with manganese, a metal that boosts magnetic resonance imaging signals, and an antibody that targets blood vessels, the investigators then created a new type of imaging agent that also has the potential to deliver drugs to tumors.

9 Jul 2008

Researchers mimic bacteria to synthesize magnetic nanoparticles for drug targeting and delivery

When it comes to designing something, it's hard to find a better source of inspiration than Mother Nature.

15 Apr 2008

Watery pools in bone marrow key to psoriatic arthritic damage

Researchers have learned more about how a leading drug prevents certain types of arthritis from eating away at bone, according to a study published in the March edition of the Annals of the Rheumatic Diseases.

4 Mar 2008

CT scan can harm kidneys, but cheap drug can help

As more and more Americans undergo CT scans and other medical imaging scans involving intense X-rays, a new study suggests that many of them should take a pre-scan drug that could protect their kidneys from damage.

20 Feb 2008

Allergic-like reactions occur in premedicated patients

Allergic-like reactions can occur in patients (both children and adults) when given gadolinium containing contrast agents, even if they have been pre-medicated with corticosteroids and antihistamines, according to a recent study conducted by researchers at the University of Michigan Health Systems in Ann Arbor.

11 Feb 2008

Allergic reactions to gadolinium-containing contrast injections - study

Allergic-like reactions to gadolinium-containing contrast injections in adults and pediatric patients (those younger than 19 years of age) are rare, according to a recent study conducted by researchers at the University of Michigan Health Systems in Ann Arbor.

2 Jan 2008

Medical causes of iatrogenic renal disorders

Nephrologists and other health care providers need to be aware of certain medications and diagnostic test preparations that, in some patients, can cause damage to the kidneys, according to a special clinical update being presented at the American Society of Nephrology's 40th Annual Meeting and Scientific Exposition in San Francisco.

5 Nov 2007

Painful condition affecting kidney failure patients increases risk of death

A painful and debilitating condition that affects patients with kidney failure may be more common than previously believed and appears to be strongly associated with prior exposure to certain contrast agents used in imaging studies.

29 Sep 2007

Higher death rates in kidney patients with nephrogenic systemic fibrosis

Nephrogenic systemic fibrosis (NSF) is a newly identified debilitating and painful condition that affects patients with kidney failure and is characterized by a thickening and hardening of the skin.

29 Sep 2007

Possible cause of nephrogenic systemic fibrosis found

New findings from researchers at Wake Forest University Baptist Medical Center and colleagues suggest why some people with kidney failure can develop a rare tightening and swelling of the skin and other organs, including the lungs and heart.

25 Sep 2007

Real-time, direct MRI monitoring of vector distribution within the brain

A team of scientists, led by Dr. Krystof Bankiewicz, University of California-San Francisco, presented this significant advance, which allows, for the first time, to adjust parameters of vector infusion while delivering gene therapy, giving surgeon full control over gene transfer technology.

3 Jun 2007

MRI effective method for revealing anatomical details of soft tissues

Contrast agents can help to make these images even clearer and allow physiological processes to be followed in real time. Conventional gadolinium complexes currently used as MRI contrast agent cannot reveal anatomic structures.

1 Jun 2007

Pharmacyclics announces NDA for Xcytrin injection

Pharmacyclics, Inc. has announced that the U.S. Food and Drug Administration (FDA) has filed the company's New Drug Application (NDA) for Xcytrin (motexafin gadolinium) Injection.

24 Apr 2007

New, potentially more accurate method for diagnosing breast cancer

By combining two techniques, magnetic resonance imaging (MRI) and near-infrared optics, researchers at Dartmouth College and Dartmouth Medical School may have devised a new, potentially more accurate method for diagnosing breast cancer.

14 Apr 2007

dGEMRIC index as a predictor of cartilage mechanical stiffness

Can non-destructive MRI provide a measurement of cartilage function? The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) index is highly correlated to mechanical stiffness, and, although not as good as a direct mechanical measurement, the index can be used as a predictive measure of stiffness.

11 Apr 2007