Gastroenterology News and Research

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Gastroenterology is the branch of medicine where the digestive system and its disorders are studied.

Sucampo presents phase 3 trial results of lubiprostone in non-cancer pain patients with OBD at DDW 2010

Sucampo Pharmaceuticals, Inc. today announced the presentation of results from a phase 3 clinical trial investigating the use of lubiprostone in non-cancer pain patients with Opioid-induced Bowel Dysfunction (OBD). These results were the subject of an oral presentation at the Digestive Disease Week (DDW) 2010 conference in New Orleans, Louisiana, on May 5, 2010.

11 May 2010

Ferring to acquire global rights to Xanodyne Pharmaceutical's LYSTEDA

Ferring Pharmaceuticals today announced an agreement that will expand its Women's Health product portfolio with the acquisition of the global rights to Xanodyne Pharmaceutical's LYSTEDA™ (tranexamic acid), a first-in-class, non-hormonal therapy indicated specifically for treatment of women with cyclic heavy menstrual bleeding (HMB).

10 May 2010

Forest, Nycomed to present data from six roflumilast posters at ATS International Conference

Forest Laboratories, Inc. and Nycomed today announced that they will present data from six roflumilast posters during the American Thoracic Society (ATS) International Conference being held in New Orleans, LA, May 14 through May 19, 2010. Roflumilast is an investigational anti-inflammatory, oral medication for the treatment of Chronic Obstructive Pulmonary Disease (COPD) associated with chronic bronchitis in patients at risk of exacerbations.

10 May 2010

CE 3D US creates spatial view for hemodynamic and morphologic evaluation of focal liver tumors

Recently, contrast-enhanced (CE) ultrasound (US) appeared as an important modality to show the vascularity in the areas of interest, and has been used widely in clinical diagnosis of liver lesions. Three dimensional ultrasonography (3D US) allows three orthogonal planes to spatially demonstrate the features of subjects, which has been frequently used in fetal US.

10 May 2010

Double-balloon endoscopy reveals intestinal lipomas within jejunal duplication cysts

Lipoma of the small intestine is a benign tumor of mesenchymal origin which is mostly found by chance during gastrointestinal investigation. Invaginations account for 2/3 of small bowel occlusion caused by up to 80% of tumors and the lipoma is the most frequent benign tumor that causes invagination in its submucous polypoid and it is in more or less scissile form.

10 May 2010

H. pylori eradication therapy treatment for localized H. pylori-negative gastric MALT lymphoma

Eradication of Helicobacter pylori is a well-accepted initial therapy in cases of localized (stage ⅠE) low-grade gastric mucosa-associated lymphoid tissue lymphoma associated with H. pylori infection. However, there are no treatment guidelines for the management of H. pylori-negative low-grade gastric MALT lymphoma.

7 May 2010

Report: 34 C>G of PPAR-γ gene might be a potential therapeutic target for colon cancer

Colorectal cancer is one of the major causes of cancer death in the developed countries. Accumulated evidences indicate that lipid metabolism, especially the one in the arachidonic acid -pathway, appears to play a critical role in the development of CRC.

7 May 2010

Researchers investigate aberrant expression of nuclear matrix proteins in gastric cancer cells

Gastric cancer is the most common malignant gastrointestinal cancer and accounts for 25% of cancer deaths. Nuclear matrix, a filamentous protein framework for eukaryotic cellular chromatin, closely relates to DNA duplication and transcription. Research on nuclear matrix proteins will provide insight into how tumors developed.

7 May 2010

Warner Chilcott reports 209.5% increase in first-quarter 2010 revenues

Warner Chilcott plc today announced its results for the quarter ended March 31, 2010. Revenue in the quarter was $761.3 million, an increase of $515.3 million, or 209.5%, over the prior year quarter.

7 May 2010

Minimally invasive scopes to detect cancer

Just as cameras and televisions have been reinvented in the last decade with improved optics, sharpness and brightness, so have the tiny imaging scopes that physicians use to peer into the body's nooks and crannies -- its organs and digestive system.

7 May 2010

Hepcidin is found in various biological fluids, says new research

Recent studies have highlighted the importance of hepcidin in iron metabolism, particularly anaemia of chronic disease and iron overload. There have also been reports of its expression in various proinflammatory disorders and various organs, linking it to innate immunity and iron metabolism.

7 May 2010

Sun Pharmaceutical subsidiary granted USFDA approval for generic Namenda tablets

Sun Pharmaceutical Industries Ltd. announced that USFDA has granted its subsidiary an approval for its Abbreviated New Drug Application (ANDA) to market a generic version of Forest Laboratories, Inc.'s Namenda 5 mg and 10 mg tablets.

7 May 2010

Colonoscopy preparation drugs administered same day as procedure equally effective: Researchers

Researchers at Thomas Jefferson University have found that colonoscopy preparation drugs administered the same day as the procedure are equally effective to those given the night before and the morning of the procedure, but result in less complaints of side effects such as abdominal pain, sleep loss and workday interference.

6 May 2010

Endo Pharmaceuticals signs agreement to acquire HealthTronics

Continuing to diversify, move into new growth areas beyond pharmaceuticals, and strengthen its commitment to improved patient outcomes in urology, Endo Pharmaceuticals today announced that it has signed an agreement to acquire HealthTronics, Inc., a leading U.S. provider of urological products and services.

6 May 2010

Pay-for-performance may create unintended financial incentives for doctors to discriminate against obese patients

Pay-for-performance reimbursement models may create unintended financial incentives for doctors to discriminate against obese patients, measuring a patient's waist circumference may be more effective in predicting surgical outcomes than the more traditional body mass index measure, and childhood obesity doubles the risk of developing colon cancer, according to data being presented at Digestive Disease Week- 2010.

5 May 2010

Colorectal pre-cancer can be detected through stool DNA testing: Mayo Clinic study

Research teams led by Mayo Clinic have demonstrated for the first time that two types of colorectal pre-cancers can be detected through noninvasive stool DNA testing. The two studies being presented demonstrate that stool DNA testing may be useful for detection of premalignant dysplasia in patients with inflammatory bowel disease and of an important type of colorectal pre-cancer called serrated polyps.

5 May 2010

New pathology test may help doctors distinguish between two overlapping esophageal disorders: Study

A pathology test may help doctors distinguish between two separate but overlapping esophageal disorders that require different courses of treatment, according to a study by researchers at the University of North Carolina at Chapel Hill.

5 May 2010

Targeted antibiotics provide safe, long-lasting improvement for IBS patients, says study

A targeted antibiotic provides effective and long-lasting relief of Irritable Bowel Syndrome symptoms, according to the results of two multisite Phase III clinical trials designed by Cedars-Sinai researchers. Rifaximin is the first drug treatment for IBS that relieves symptoms while it's being administered and continues to benefit patients after they stop taking the drug.

5 May 2010

Data shows rates of colorectal cancer screening vary by race, ethnicity and method

Rates of colorectal cancer screening vary by race and ethnicity as well as method, according to data being presented at Digestive Disease Week- 2010. Scientists examine data on minority and older populations as well as utilization rates of virtual and optical colonoscopies to better understand adherence to recommended screening guidelines.

5 May 2010

ChemoCentryx reports positive data with Traficet-EN in Crohn's disease trial

ChemoCentryx, Inc., today announced that it reported positive data with Traficet-EN™ (CCX282-B) in the Maintenance period of PROTECT-1 (Prospective Randomized Oral Therapy Evaluation in Crohn's disease Trial-1). Traficet-EN maintained a clinical remission rate (Crohn's Disease Activity Index (CDAI) less than 150) of approximately 50% in Crohn's patients over the course of 36 weeks, whereas in the placebo group remission decreased progressively from 50% to 31%.

5 May 2010

Gastroenterology News and Research

Further Reading

Sucampo presents phase 3 trial results of lubiprostone in non-cancer pain patients with OBD at DDW 2010

Ferring to acquire global rights to Xanodyne Pharmaceutical's LYSTEDA

Forest, Nycomed to present data from six roflumilast posters at ATS International Conference

CE 3D US creates spatial view for hemodynamic and morphologic evaluation of focal liver tumors

Double-balloon endoscopy reveals intestinal lipomas within jejunal duplication cysts

H. pylori eradication therapy treatment for localized H. pylori-negative gastric MALT lymphoma

Report: 34 C>G of PPAR-γ gene might be a potential therapeutic target for colon cancer

Researchers investigate aberrant expression of nuclear matrix proteins in gastric cancer cells

Warner Chilcott reports 209.5% increase in first-quarter 2010 revenues

Minimally invasive scopes to detect cancer

Hepcidin is found in various biological fluids, says new research

Sun Pharmaceutical subsidiary granted USFDA approval for generic Namenda tablets

Colonoscopy preparation drugs administered same day as procedure equally effective: Researchers

Endo Pharmaceuticals signs agreement to acquire HealthTronics

Pay-for-performance may create unintended financial incentives for doctors to discriminate against obese patients

Colorectal pre-cancer can be detected through stool DNA testing: Mayo Clinic study

New pathology test may help doctors distinguish between two overlapping esophageal disorders: Study

Targeted antibiotics provide safe, long-lasting improvement for IBS patients, says study

Data shows rates of colorectal cancer screening vary by race, ethnicity and method

ChemoCentryx reports positive data with Traficet-EN in Crohn's disease trial

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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