Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Study helps explain why viruses often spread through the brain in patchwork patterns

Viruses often spread through the brain in patchwork patterns, infecting some cells but missing others. New research at Washington University School of Medicine in St. Louis helps explain why. The scientists showed that natural immune defenses that resist viral infection are turned on in some brain cells but switched off in others.

8 Mar 2013

Salk epigenetic findings may aid in crop production and study of human diseases

Scientists at the Salk Institute for Biological Studies have identified patterns of epigenomic diversity that not only allow plants to adapt to various environments, but could also benefit crop production and the study of human diseases.

7 Mar 2013

Vitamin B12 and folate alleviate negative symptoms in patients with schizophrenia

Adding the dietary supplements folate and vitamin B12 to treatment with antipsychotic medication improved a core symptom component of schizophrenia in a study of more than 100 patients.

7 Mar 2013

Scientists report successful blocking of tumor development in genetic mouse model of human cancer

UT Southwestern Medical Center scientists report the first successful blocking of tumor development in a genetic mouse model of an incurable human cancer.

6 Mar 2013

European scientists find root cause of age-related dementia

A team of European scientists from the University Medical Center Hamburg-Eppendorf and the Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases at the University of Cologne in Germany has taken an important step closer to understanding the root cause of age-related dementia.

6 Mar 2013

Idera announces new data from IMO-3100 and IMO-8400 preclinical study on psoriasis

Idera Pharmaceuticals, Inc. today announced the presentation of new data showing that its selective Toll-like receptor antagonists, IMO-3100 and IMO-8400, normalized the gene expression of important cytokines in a preclinical study of skin inflammation that is commonly used as a model of psoriasis.

4 Mar 2013

UNC1215 chemical probe can help investigate L3MBTL3 methyl-lysine reader domain

In an article published as the cover story of the March 2013 issue of Nature Chemical Biology, Lindsey James, PhD, research assistant professor in the lab of Stephen Frye, Fred Eshelman Distinguished Professor in the UNC School of Pharmacy and member of the UNC Lineberger Comprehensive Cancer Center, announced the discovery of a chemical probe that can be used to investigate the L3MBTL3 methyl-lysine reader domain.

3 Mar 2013

Researchers identify mechanisms that connect variety of diseases linked with inflammation

A study led by researchers at Boston University School of Medicine (BUSM) has identified epigenetic mechanisms that connect a variety of diseases associated with inflammation.

3 Mar 2013

Researchers elucidate how Fgf8 is controlled by multiple regulatory elements in mammal embryos

During embryo development, genes are dynamically, and very precisely, switched on and off to confer different properties to different cells and build a well-proportioned and healthy animal. Fgf8 is one of the key genes in this process, controlling in particular the growth of the limbs and the formation of the different regions of the brain. Researchers at EMBL have elucidated how Fgf8 in mammal embryos is, itself, controlled by a series of multiple, interdependent regulatory elements.

1 Mar 2013

New way to identify heterogeneous brain cells by looking at epigenetic variation

Scientists from the Johns Hopkins University School of Medicine in Baltimore, MD have developed a new way to identify heterogeneous brain cells by looking at epigenetic variation (the heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence).

1 Mar 2013

UMDNJ biochemist to research into mechanisms that control gene expression in mitochondria

Dmitry Temiakov, PhD, a biochemist at the University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, has received a five-year, $1.5 million grant from the National Institutes of Health (NIH) to fund research into the molecular mechanisms that control gene expression in mitochondria, the organelles that are the "power plants" of cellular activity.

1 Mar 2013

Blocking aPKC activity can stop growth of transplanted skin tumors resistant to vismodegib

Hailed as a major step forward in the effort to develop targeted cancer therapies, a recently approved drug for the most common type of skin cancer has been a mixed blessing for patients. Although the initial response is usually dramatic, the tumors often recur as the cancer becomes resistant to treatment.

28 Feb 2013

Molecular effects of insufficient sleep uncovered

Results from a sleep laboratory study show striking changes in gene expression associated with sleep deprivation.

27 Feb 2013

HDAC-mediated mechanisms play critical role in regulating lung repair and regeneration

Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are on the rise, according to the American Lung Association and the National Institutes of Health.

26 Feb 2013

Study confirms presence of four molecular classes of head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) is the seventh most common form of cancer in the United States, but other than an association with the human papillomavirus, no validated molecular profile of the disease has been established.

25 Feb 2013

HIF-1α protein can work directly to stop new cells from forming

A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report. Their discovery has wide-ranging implications, they say, given the importance of this copying - known as DNA replication - and new cell growth to many of the body's functions and in such diseases as cancer.

23 Feb 2013

Study may help design better DAA drug cocktails to treat HCV

Hepatitis C virus (HCV) infection affects about 4 million in the United States and is the primary cause of liver cirrhosis and liver cancer. Current therapy against HCV is suboptimal. Daclatasvir, a direct acting antiviral (DAA) agent in development for the treatment of HCV, targets one of the HCV proteins (i.e., NS5A) and causes the fastest viral decline (within 12 hours of treatment) ever seen with anti-HCV drugs.

20 Feb 2013

Scientists explore development of unique dentition of 'toothed whales'

Whales are mammals, but they don't look like the mammals living around us, as they have a triangular fluke for tail, no hind legs and no body hair. And inside their mouths, their teeth are unfamiliar too - being much simpler and 'peg like'. A multidisciplinary team of researchers have now married together the fossil record and the embryonic development process to investigate how the whale got its teeth.

19 Feb 2013

Real-time PCR reproducibility improved by handheld electronic pipette

INTEGRA has reported how a leading US clinical diagnostic laboratory has, using a VIAFLO 96 handheld electronic pipette, significantly improved the reproducibility and productivity with which it carries out Real-time PCR assays.

From INTEGRA Biosciences 19 Feb 2013

Article details mechanism by which long non-coding RNA-activators promote gene expression

Long segments of RNA- encoded in our DNA but not translated into protein-are key to physically manipulating DNA in order to activate certain genes, say researchers at The Wistar Institute. These non-coding RNA-activators (ncRNA-a) have a crucial role in turning genes on and off during early embryonic development, researchers say, and have also been connected with diseases, including some cancers, in adults.

18 Feb 2013

Gene Expression News and Research

Further Reading

Study helps explain why viruses often spread through the brain in patchwork patterns

Salk epigenetic findings may aid in crop production and study of human diseases

Vitamin B12 and folate alleviate negative symptoms in patients with schizophrenia

Scientists report successful blocking of tumor development in genetic mouse model of human cancer

European scientists find root cause of age-related dementia

Idera announces new data from IMO-3100 and IMO-8400 preclinical study on psoriasis

UNC1215 chemical probe can help investigate L3MBTL3 methyl-lysine reader domain

Researchers identify mechanisms that connect variety of diseases linked with inflammation

Researchers elucidate how Fgf8 is controlled by multiple regulatory elements in mammal embryos

New way to identify heterogeneous brain cells by looking at epigenetic variation

UMDNJ biochemist to research into mechanisms that control gene expression in mitochondria

Blocking aPKC activity can stop growth of transplanted skin tumors resistant to vismodegib

Molecular effects of insufficient sleep uncovered

HDAC-mediated mechanisms play critical role in regulating lung repair and regeneration

Study confirms presence of four molecular classes of head and neck squamous cell carcinoma

HIF-1α protein can work directly to stop new cells from forming

Study may help design better DAA drug cocktails to treat HCV

Scientists explore development of unique dentition of 'toothed whales'

Real-time PCR reproducibility improved by handheld electronic pipette

Article details mechanism by which long non-coding RNA-activators promote gene expression

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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