Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Allegro Diagnostics announces results from BronchoGen genomic test trial on lung cancer

Allegro Diagnostics today announced that results from its AEGIS (Airway Epithelium Gene Expression In the Diagnosis of Lung Cancer) clinical trials, to determine the accuracy of the BronchoGen genomic test, have been accepted for an oral presentation during the late-breaking abstract session at CHEST 2012 on Tuesday, October 23, 2012 at 4:30 p.m. The abstract will also be published in a supplement of the October 2012 issue of CHEST.

28 Aug 2012

CardioDx completes two-tranche equity financing

CardioDx, Inc., a pioneer in the field of cardiovascular genomic diagnostics, today announced the completion of a $58 million two-tranche equity financing.

27 Aug 2012

Parental methylated histones not transferred to daughter DNA

It's widely accepted that molecular mechanisms mediating epigenetics include DNA methylation and histone modifications, but a team from Thomas Jefferson University has evidence to the contrary regarding the role of histone modifications.

24 Aug 2012

Certain human diseases may have evolutionary epigenetic origins

Ninety-six percent of a chimpanzee's genome is the same as a human's. It's the other 4 percent, and the vast differences, that pique the interest of Georgia Tech's Soojin Yi. For instance, why do humans have a high risk of cancer, even though chimps rarely develop the disease? In research published in September's American Journal of Human Genetics, Yi looked at brain samples of each species. She found that differences in certain DNA modifications, called methylation, may contribute to phenotypic changes.

24 Aug 2012

Changes in DNA methylation might be linked to evolution of humans' vulnerability to diseases

Chimpanzees rarely get cancer, or a variety of other diseases that commonly arise in humans, but their genomic DNA sequence is nearly identical to ours. So, what's their secret? Researchers reporting in the September issue of the American Journal of Human Genetics, a Cell Press journal, have found that differences in certain DNA modifications, called methylation, might play a role.

24 Aug 2012

Influenza virus can change microRNA expression to control immune responses in human lung cells

When you are hit with the flu, you know it immediately -- fever, chills, sore throat, aching muscles, fatigue. This is your body mounting an immune response to the invading virus. But less is known about what is happening on the molecular level.

24 Aug 2012

New UCLA study pinpoints unique human patterns of gene activity in the brain

Human and chimp brains look anatomically similar because both evolved from the same ancestor millions of years ago. But where does the chimp brain end and the human brain begin? A new UCLA study pinpoints uniquely human patterns of gene activity in the brain that could shed light on how we evolved differently than our closest relative.

23 Aug 2012

Researchers report how Alzheimer's protein deposits disrupt signalling between nerve cells

How abnormal protein deposits in the brains of Alzheimer's patients disrupt the signalling between nerve cells has now been reported by researchers in Bochum and Munich, led by Dr. Thorsten M-ller from the Medizinisches Proteom-Center of the Ruhr-Universit-t, in the journal Molecular and Cellular Proteomics. They varied the amount of APP protein and related proteins associated with Alzheimer's disease in cell cultures, and then analysed how this manipulation affected other proteins in the cell.

22 Aug 2012

Mof protein plays a key role in epigenetics of stem cells

How do stem cells preserve their ability to become any type of cell in the body? And how do they "decide" to give up that magical state and start specializing? If researchers could answer these questions, our ability to harness stem cells to treat disease could explode. Now, a University of Michigan Medical School team has published a key discovery that could help that goal become reality.

22 Aug 2012

Investigators discover biological explanation for why low levels of oxygen advance SMA symptoms

Investigators at Nationwide Children's Hospital may have discovered a biological explanation for why low levels of oxygen advance spinal muscular atrophy (SMA) symptoms and why breathing treatments help SMA patients live longer. The findings appear in Human Molecular Genetics.

22 Aug 2012

New silicon chips help identify patients with lupus

Researchers at the Stanford University School of Medicine and Intel Corp. have collaborated to synthesize and study a grid-like array of short pieces of a disease-associated protein on silicon chips normally used in computer microprocessors.

21 Aug 2012

Study utilizes integrative approach to probe biology of bipolar disorder

The more that we understand the brain, the more complex it becomes. The same can be said about the genetics and neurobiology of psychiatric disorders. For "Mendelian" disorders, like Huntington disease, mutation of a single gene predictably produces a single clinical disorder, following relatively simple genetic principals. Compared to Mendelian disorders, understanding bipolar disorder has been extremely challenging. Its biology is not well understood and its genetics are complex.

21 Aug 2012

Agilent awarded patent for comparative genomic hybridization methods

Agilent Technologies Inc. today announced that it was awarded a significant patent for comparative genomic hybridization methods. CGH methods help researchers study genetics and cancer in both basic and clinical research.

20 Aug 2012

Computer simulations shed light on dynamic structure of major target for anti-cancer drugs

Using advanced computer simulations, University of Utah College of Pharmacy researchers have produced moving images of a protein complex that is an important target for anti-cancer drugs.

18 Aug 2012

Researchers identify molecular and protein signatures that predict HCV virus-induced liver injury

Researchers have discovered molecular and protein signatures that predict rapid onset of liver damage in hepatitis C patients following a liver transplant. The markers appeared soon after transplant and well before clinical evidence of liver damage.

17 Aug 2012

Radiosensitivity molecular signature can lead to better radiation therapy decisions for breast cancer

Researchers at Moffitt Cancer Center, working with colleagues in Sweden, the Netherlands and Puerto Rico, have validated a radiosensitivity molecular signature that can lead to better radiation therapy decisions for treating patients with breast cancer.

16 Aug 2012

Researchers discover why people with sickle cell disease get milder cases of malaria

Researchers at Duke University Medical Center may finally have discovered why people with sickle cell disease get milder cases of malaria than individuals who have normal red blood cells.

16 Aug 2012

Rice University researcher to see how delays in gene transcription affect cellular processes

A Rice University researcher and his colleagues have received a National Institutes of Health grant to see how delays in gene transcription - life's most basic messaging system - affect cellular processes.

16 Aug 2012

Mindfulness meditation prevents feelings of loneliness

Many elderly people spend their last years alone. Spouses pass and children scatter. But being lonely is much more than a silent house and a lack of companionship. Over time, loneliness not only takes a toll on the psyche but can have a serious physical impact as well.

15 Aug 2012

Two papers may help identify gene variants that contribute to OCD or Tourette syndrome

Two papers that will appear in the journal Molecular Psychiatry, both receiving advance online release, may help identify gene variants that contribute to the risks of developing obsessive-compulsive disorder (OCD) or Tourette syndrome (TS). Both multi-institutional studies were led by Massachusetts General Hospital (MGH) investigators, and both are the first genome-wide association studies (GWAS) in the largest groups of individuals affected by the conditions.

15 Aug 2012

Gene Expression News and Research

Further Reading

Allegro Diagnostics announces results from BronchoGen genomic test trial on lung cancer

CardioDx completes two-tranche equity financing

Parental methylated histones not transferred to daughter DNA

Certain human diseases may have evolutionary epigenetic origins

Changes in DNA methylation might be linked to evolution of humans' vulnerability to diseases

Influenza virus can change microRNA expression to control immune responses in human lung cells

New UCLA study pinpoints unique human patterns of gene activity in the brain

Researchers report how Alzheimer's protein deposits disrupt signalling between nerve cells

Mof protein plays a key role in epigenetics of stem cells

Investigators discover biological explanation for why low levels of oxygen advance SMA symptoms

New silicon chips help identify patients with lupus

Study utilizes integrative approach to probe biology of bipolar disorder

Agilent awarded patent for comparative genomic hybridization methods

Computer simulations shed light on dynamic structure of major target for anti-cancer drugs

Researchers identify molecular and protein signatures that predict HCV virus-induced liver injury

Radiosensitivity molecular signature can lead to better radiation therapy decisions for breast cancer

Researchers discover why people with sickle cell disease get milder cases of malaria

Rice University researcher to see how delays in gene transcription affect cellular processes

Mindfulness meditation prevents feelings of loneliness

Two papers may help identify gene variants that contribute to OCD or Tourette syndrome

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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