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Scientists uncover SREBP-2 role in autophagy and cholesterol generation

Not all cholesterol is bad. Every cell requires it for growth - they either have to get cholesterol somewhere or they die. In a new study published April 6 in the journal Cell Metabolism, researchers from Sanford-Burnham Medical Research Institute and their collaborators found that a protein sensor known to balance cholesterol sources can also access a previously underappreciated cellular fat storage depot.

6 Apr 2011

Zebrafish research suggests new drug targets and markers to help treat melanoma

Thanks to the zebrafish, there is new hope for people with melanoma, an aggressive skin cancer that is responsible for approximately 8,700 deaths each year in the United States.

5 Apr 2011

Ubiquitine D gene may be linked to celiac disease

Celiac disease (CD) involves intolerance to gluten and, consequently, suffering chronic illness in the small intestine. It is a genetic disorder, the immunological indications of which can be traced in the human body prior to the everyday activities of future sufferers being affected. For example, persons with genetic antecedents for CD develop antibodies against the gene tTG (the enzyme known as tissue transglutaminase), even before the illness becomes active, due to a cell reaction against gluten.

5 Apr 2011

Preliminary discovery may help individualize prostate cancer screening in the future

Prostate cancer is the second leading cause of cancer-related death among American men. Yet population-wide screening programs have not reduced the number of deaths from the disease. By focusing screening programs on the men who are at greatest risk for aggressive disease or diagnosis at a young age, researchers think they could improve mortality rates and personalize the screening approach.

5 Apr 2011

Scientists identify gene influencing levels of alcohol consumption

Scientists have identified a gene that appears to play a role in regulating how much alcohol people drink, in a study of over 47,000 people published today in Proceedings of the National Academy of Sciences.

5 Apr 2011

Scientists suggest genetic differences in breast tissue across ethnicities

Scientists from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are working on a series of genetic analyses that suggest the underlying differences among racial groups are present not just in tumors, but in normal tissue as well. Lisa Baumbach, Ph.D., associate research professor, and colleagues will present the full study results at the AACR 102nd Annual Meeting 2011, held here April 2-6.

5 Apr 2011

Synta presents ganetespib and elesclomol study data in cancer at AACR meeting

Synta Pharmaceuticals Corp. today presented five posters at the American Association for Cancer Research 102nd Annual Meeting. Three posters reported results from studies of ganetespib, and two posters reported results from studies of elesclomol, a small-molecule mitochondria metabolism inhibitor.

5 Apr 2011

American Cancer Society awards 85 institutions with $49,213,000 for new research, training

The American Cancer Society, the largest non-government, not-for-profit funding source of cancer research in the United States, has awarded 132 national research and training grants totaling $49,213,000 to 85 institutions nationwide in the second of two grants cycles for 2011.

5 Apr 2011

Children with DCD tend to feel more emotionally isolated, less coherent and less optimistic

Attention Deficit Hyperactivity Disorder, or ADHD, is widely recognized by the medical community, and there are a number of therapies in place. But as many as six percent of all children suffer from the less familiar Developmental Coordination Disorder (DCD). Demonstrating a lack of refined motor skills, children with DCD tend to have a more difficult time playing sports and staying organized at school. They appear to be uncoordinated - and many parents think they'll grow out of it. But research shows that may not be true.

5 Apr 2011

Neuropeptide ghrelin impacts alcoholism, binge-eating and sugar consumption

The substance ghrelin plays an important role in various addictions, such as alcoholism and binge-eating. It also impacts on sugar consumption, which is due, in part, to genetic factors, reveals new research from the University of Gothenburg, Sweden.

5 Apr 2011

Alcohol binge-drinking in teen years could affect decision-making and related behaviors as adults

Adolescents represent the majority of people who binge drink. This may come as a surprise to some, but recent surveys indicate that episodes of heavy alcohol drinking within the previous two weeks are reported by 12 percent of 8th graders, 22 percent of 10th graders, 28 percent of 12th grade seniors and 44 percent of college students.

5 Apr 2011

Women with ovarian cancer having BRCA2 gene mutations are more likely to survive

Women with ovarian cancer who have the BRCA2 gene mutation are more likely to survive the malignancy than women with the BRCA1 mutation, or women without either mutation.

5 Apr 2011

Heavy beer drinkers with specific genetic variant at increased risk of non-cardia gastric cancer

Heavy beer drinkers who have a specific genetic variant in the cluster of three genes that metabolize alcohol are at significantly higher risk of developing non-cardia gastric cancer, according to research presented at the AACR 102nd Annual Meeting 2011, held here April 2-6.

5 Apr 2011

Lilly presents results of JAK2, Hedgehog inhibitor preclinical cancer studies at 102nd AACR

Eli Lilly and Company announced results today from two preclinical studies of molecules that target genetic mutations and disable specific signaling pathways that can lead to cancer. The studies evaluated two unique molecules – a JAK2 inhibitor and a Hedgehog inhibitor – with results presented during the American Association for Cancer Research (AACR) 102nd Annual Meeting in Orlando, Fla.

5 Apr 2011

Vitamin D can reduce estrogen receptor-positive breast cancer

In mice models of breast cancer, researchers at the Georgetown Lombardi Comprehensive Cancer Center, a part of Georgetown University Medical Center, found that vitamin D significantly reduced development of estrogen receptor-positive breast cancer both in lean and obese mice, but had no beneficial effect in estrogen receptor-negative cancer.

5 Apr 2011

Genetic factors can explain people's susceptibility to urinary incontinence

Much of the risk of developing incontinence before middle age is determined by our genes. Genetic factors can explain half of people's susceptibility to urinary incontinence, a study of twins at the University of Gothenburg and Karolinska Institutet reveals.

5 Apr 2011

Breast cancer updates

According to the latest research human breast milk holds the potential to assess a woman’s risk of developing breast cancer.

5 Apr 2011

Stand Up to Cancer awards UNC Lineberger scientist with 13 Innovative Research Grants

Angelique Whitehurst, PhD, assistant professor of pharmacology and a member of UNC Lineberger Comprehensive Cancer Center, has been awarded one of 13 Innovative Research Grants from Stand Up to Cancer, the scientific partner of the American Association of Cancer Research.

5 Apr 2011

Researchers identify new gene that can influence person's risk of developing epilepsy

Vanderbilt University researchers have identified a new gene that can influence a person's risk for developing epilepsy. The findings, reported in the March 29 Proceedings of the National Academy of Sciences, could improve molecular diagnostic tools and point to novel therapeutic targets for epilepsy.

5 Apr 2011

Epithelial cells in breast milk can help assess breast cancer risk

Breast cancer risk can be assessed by examining the epithelial cells found in breast milk, according to preliminary study results presented at the AACR 102nd Annual Meeting 2011, held April 2-6.

4 Apr 2011

Genes News and Research

Scientists uncover SREBP-2 role in autophagy and cholesterol generation

Zebrafish research suggests new drug targets and markers to help treat melanoma

Ubiquitine D gene may be linked to celiac disease

Preliminary discovery may help individualize prostate cancer screening in the future

Scientists identify gene influencing levels of alcohol consumption

Scientists suggest genetic differences in breast tissue across ethnicities

Synta presents ganetespib and elesclomol study data in cancer at AACR meeting

American Cancer Society awards 85 institutions with $49,213,000 for new research, training

Children with DCD tend to feel more emotionally isolated, less coherent and less optimistic

Neuropeptide ghrelin impacts alcoholism, binge-eating and sugar consumption

Alcohol binge-drinking in teen years could affect decision-making and related behaviors as adults

Women with ovarian cancer having BRCA2 gene mutations are more likely to survive

Heavy beer drinkers with specific genetic variant at increased risk of non-cardia gastric cancer

Lilly presents results of JAK2, Hedgehog inhibitor preclinical cancer studies at 102nd AACR

Vitamin D can reduce estrogen receptor-positive breast cancer

Genetic factors can explain people's susceptibility to urinary incontinence

Breast cancer updates

Stand Up to Cancer awards UNC Lineberger scientist with 13 Innovative Research Grants

Researchers identify new gene that can influence person's risk of developing epilepsy

Epithelial cells in breast milk can help assess breast cancer risk

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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