Genes News and Research

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Discovery of cells responsible for bladder cancer spread

Johns Hopkins scientists have tracked down a powerful set of cells in bladder tumors that seem to be primarily responsible for the cancer's growth and spread using a technique that takes advantage of similarities between tumor and organ growth. The findings, reported in the July Stem Cells, could help scientists develop new ways of finding and attacking similar cells in other types of cancer.

6 Aug 2009

Distinctive gene expression in brains of relapsing heroin-addicted rats

A group of genes whose expression is significantly altered following exposure to drug paraphernalia after an enforced 'cold-turkey' period have been identified. Researchers writing in the open access journal BMC Neuroscience studied gene expression in the brains of heroin-addicted rats, identifying those genes that may be involved in precipitating a relapse.

6 Aug 2009

Discovery of 'tell-tale' viral signature in blood that identifies underlying viral infection

Scientists have identified a genomic "signature" in circulating blood that reveals exposure to common upper respiratory viruses, like the cold or flu, even before symptoms appear.

6 Aug 2009

Colon cancer may yield to cellular sugar starvation

Scientists at the Johns Hopkins Kimmel Cancer Center have discovered how two cancer-promoting genes enhance a tumor's capacity to grow and survive under conditions where normal cells die.

6 Aug 2009

Alnylam and Tekmira to collaborate on RNAi therapeutics

Alnylam Pharmaceuticals, Inc. and Tekmira Pharmaceuticals Corporation announced today that they will jointly participate in a new research collaboration focused on the discovery of novel cationic lipids and lipid nanoparticles for the systemic delivery of RNAi therapeutics.

6 Aug 2009

Unstable proteins can cause premature ageing

The normal ageing process has long been linked to problems with cell respiration, the process through which the cells extract energy from nutrients.

6 Aug 2009

Scientists isolate protein that affects both the expression of genes and the transport of proteins

Scientists at UC Santa Barbara have isolated a unique protein that appears to have a dual function and could lead to a "boon in medicine." The findings are published in the August issue of the Journal of Cell Biology.

6 Aug 2009

Sensitizing tumor response to cancer treatment

Two forms of skin and brain cancer respond very poorly to chemotherapy and radiation: melanoma and glioblastoma multiforme brain cancer.

5 Aug 2009

Discovery of new gene mutations linked to leukemia

Decoding the complete DNA of cancer patients is giving scientists at Washington University School of Medicine in St. Louis a clearer picture of the complexity of the disease and allowing them to see intriguing and unexpected genetic relationships among patients.

5 Aug 2009

Innovative diabetes drug discovery partnership

The Juvenile Diabetes Research Foundation said today that it has entered into a novel collaborative research agreement with the Genomics Institute of the Novartis Research Foundation (GNF) to create a diabetes drug discovery and development platform.

5 Aug 2009

Epigenetic alterations may serve as markers for chronic leukemia

A new study shows that certain genes are turned off early, before clinical signs of the disease appear, in the development of chronic leukemia.

5 Aug 2009

Iowa funds swine vaccine research

A grant from a state economic development fund will help Iowa State University researchers develop and evaluate a vaccine designed to protect swine from novel H1N1 and other strains of influenza.

5 Aug 2009

New understanding on Gleevec's limitations

University of Michigan researchers have developed an animal model that provides strong evidence why imatinib, marketed as Gleevec, helps patients with chronic myeloid leukemia survive longer, but does not keep the disease from returning if treatment ends.

4 Aug 2009

Silenced genes provide warning sign of blood cancer

In many types of cancer, parts of the genetic material of tumor cells are switched off by chemical labels called methyl groups. This kind of methyl labeling ranges among the epigenetic changes that do not change the sequence of DNA building blocks. Such labels are found particularly often in genes which act as important inhibitors of pathogenic cell growth.

4 Aug 2009

Discovery of novel tumor suppressor

4 Aug 2009

Stem cell technology innovation could reduce the number of animal experiments

Researchers from the University of Bath are embarking on a project to use stem cell technology that could reduce the number of animal experiments used to study conditions such as motor neurone disease.

4 Aug 2009

Genetic link to ovarian cancer found

Scientists have located a region of DNA which - when altered - can increase the risk of ovarian cancer according to research published in Nature Genetics today.

3 Aug 2009

Discovery of mechanism that protects somatic cells against the behaviour of germ cells

An IRB Barcelona research team discovers the mechanism that favors the correct separation of germ cells -- future ovules and sperm -- from the rest of the cells during embryonic development

3 Aug 2009

Discovery of unique 'DNA signature' in human sperm - unlocks egg's fertility

Drs David Miller and David Iles from the University of Leeds, in collaboration with Dr Martin Brinkworth at the University of Bradford, have found that sperm writes a DNA signature that can only be recognised by an egg from the same species. This enables fertilisation and may even explain how a species develops its own unique genetic identity.

3 Aug 2009

Discovery of novel tumor suppressor

La Jolla Institute for Allergy & Immunology researchers studying an enzyme believed to play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma and leukemia. Myeloproliferative diseases are a group of disorders characterized by an overproduction of blood cells by the bone marrow and include chronic myeloid leukemia. Lymphoma and leukemia are cancers of the blood.

3 Aug 2009