Genes News and Research

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Researchers identify novel signaling pathway responsible for neuroprotective activity of parkin

Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich identify a novel signal transduction pathway, which activates the parkin gene and prevents stress-induced neuronal cell death.

2 Mar 2013

Kallikrein gene variants modulate OSCC development

Polymorphisms in the kallikrein7 and kallikrein10 genes are associated with the development and progression of oral squamous cell carcinoma, a study in Taiwanese men indicates.

1 Mar 2013

RNA interference identifies function of genes linked with cardiovascular disease

Studies screening the genome of hundreds of thousands of individuals (known as Genome-wide association studies or GWAS) have linked more than 100 regions in the genome to the risk of developing cardiovascular disease.

1 Mar 2013

Researchers elucidate how Fgf8 is controlled by multiple regulatory elements in mammal embryos

During embryo development, genes are dynamically, and very precisely, switched on and off to confer different properties to different cells and build a well-proportioned and healthy animal. Fgf8 is one of the key genes in this process, controlling in particular the growth of the limbs and the formation of the different regions of the brain. Researchers at EMBL have elucidated how Fgf8 in mammal embryos is, itself, controlled by a series of multiple, interdependent regulatory elements.

1 Mar 2013

Not all acne bacteria trigger pimples: Study

The bacteria that cause acne live on everyone's skin, yet one in five people is lucky enough to develop only an occasional pimple over a lifetime.

1 Mar 2013

UPV/EHU team uses lipid nanoparticles to develop new formulations for drug delivery

At the Faculty of Pharmacy of the Basque Public University (UPV/EHU) the Pharmacokinetics, Nanotechnology and Gene Therapy research team is using nanotechnology to develop new formulations that can be applied to drugs and gene therapy.

1 Mar 2013

Blocking aPKC activity can stop growth of transplanted skin tumors resistant to vismodegib

Hailed as a major step forward in the effort to develop targeted cancer therapies, a recently approved drug for the most common type of skin cancer has been a mixed blessing for patients. Although the initial response is usually dramatic, the tumors often recur as the cancer becomes resistant to treatment.

28 Feb 2013

Autism, ADHD, bipolar disorder, major depressive disorder and schizophrenia share common genetic risk factors

For the first time, scientists have discovered that five major psychiatric disorders—autism, attention deficit-hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder and schizophrenia—share several common genetic risk factors.

28 Feb 2013

Two antagonistic proteins help keep leukemia at bay

Two proteins that scientists once thought carried out the same functions are actually antagonists of each other, and keeping them in balance is key to preventing diseases such as cancer, according to new findings published in the February 25 issue of Developmental Cell by scientists at Fox Chase Cancer Center.

27 Feb 2013

Molecular effects of insufficient sleep uncovered

Results from a sleep laboratory study show striking changes in gene expression associated with sleep deprivation.

27 Feb 2013

Calcium channel risk allele linked to executive function in bipolar disorder

Researchers have found an allele in a voltage-gated calcium gene that is associated with an increased risk for poor executive function in patients with bipolar disorder.

27 Feb 2013

Surgical site infections appear to have significant genetic connections

An estimated 300,000 U.S. patients get surgical site infections every year, and while the causes are varied, a new University of Utah study suggests that some who get an infection can blame it partly on their genes.

27 Feb 2013

Finding solutions to global health problems might mean creating more risk

"Scientists are aware that their interventions in the natural world will have unintended effects, and in order to behave ethically, these potential risks must be considered," Maggie Koerth-Baker, science editor at BoingBoing.net, writes in a New York Times opinion piece, adding, "Even something as innocuous as a mosquito net may carry a considerable downside."

26 Feb 2013

Researchers improve NanoVelcro device to better grab cancer cells as blood passes by them

Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients' tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis.

26 Feb 2013

Insight into cellular operations that give extraordinary staying power to S. mansoni

From the point of view of its ultimate (human) host, the parasitic flatworm Schistosoma mansoni has a gruesome way of life. It hatches in feces-tainted water, grows into a larva in the body of a snail and then burrows through human skin to take up residence in the veins. Once there, it grows into an adult, mates and, if it's female, starts laying eggs. It can remain in the body for decades.

26 Feb 2013

LabCorp introduces GeneSeq: Carido for familial cardiac disease

Laboratory Corporation of America Holdings today announced it has launched its clinical next generation sequencing assay, GeneSeq: Cardio for genetic causes of familial cardiac disease.

26 Feb 2013

Genetic testing strategy for familial high cholesterol questioned

Current testing strategies for the families of patients with familial hypercholesterolemia may not be an efficient use of health resources, suggest study results published in The Lancet.

25 Feb 2013

Researchers map complex interactions of proteins that control inflammation

Inflammatory response plays a major role in both health protection and disease generation. While the symptoms of disease-related inflammatory response have been know, scientists have not understood the mechanisms that underlie it.

25 Feb 2013

Study shows how pseudogenes can regulate activity of PTEN cancer-related gene

Small stretches of DNA in the human genome are known as "pseudogenes" because, while their sequences are nearly identical to those of various genes, they have long been thought to be non-coding "junk" DNA.

25 Feb 2013

Researchers identify new pseudogene that regulates tumour-suppressing PTEN

Researchers at Karolinska Institutet in Sweden have identified a new so-called pseudogene that regulates the tumour-suppressing PTEN gene. They hope that this pseudogene will be able to control PTEN to reverse the tumour process, make the cancer tumour more sensitive to chemotherapy and to prevent the development of resistance.

25 Feb 2013

Genes News and Research

Researchers identify novel signaling pathway responsible for neuroprotective activity of parkin

Kallikrein gene variants modulate OSCC development

RNA interference identifies function of genes linked with cardiovascular disease

Researchers elucidate how Fgf8 is controlled by multiple regulatory elements in mammal embryos

Not all acne bacteria trigger pimples: Study

UPV/EHU team uses lipid nanoparticles to develop new formulations for drug delivery

Blocking aPKC activity can stop growth of transplanted skin tumors resistant to vismodegib

Autism, ADHD, bipolar disorder, major depressive disorder and schizophrenia share common genetic risk factors

Two antagonistic proteins help keep leukemia at bay

Molecular effects of insufficient sleep uncovered

Calcium channel risk allele linked to executive function in bipolar disorder

Surgical site infections appear to have significant genetic connections

Finding solutions to global health problems might mean creating more risk

Researchers improve NanoVelcro device to better grab cancer cells as blood passes by them

Insight into cellular operations that give extraordinary staying power to S. mansoni

LabCorp introduces GeneSeq: Carido for familial cardiac disease

Genetic testing strategy for familial high cholesterol questioned

Researchers map complex interactions of proteins that control inflammation

Study shows how pseudogenes can regulate activity of PTEN cancer-related gene

Researchers identify new pseudogene that regulates tumour-suppressing PTEN

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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