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Maternal bariatric surgery affects cardiovascular risk profile of offsprings

Kids born to moms who have lost a substantial amount of weight after undergoing bariatric surgery have fewer cardiovascular risk factors than their siblings who were born before the weight loss surgery.

29 Oct 2012

Researchers identify genes linked to serous endometrial cancer

Researchers have identified several genes that are linked to one of the most lethal forms of uterine cancer, serous endometrial cancer.

29 Oct 2012

Idea of nuclear reprogramming holds promise for repairing damaged tissue

The idea of taking a mature cell and removing its identity (nuclear reprogramming) so that it can then become any kind of cell, holds great promise for repairing damaged tissue or replacing bone marrow after chemotherapy.

29 Oct 2012

Researchers use baker's yeast to identify new therapies for Lou Gehrig's disease

Amyotrophic lateral sclerosis, also called Lou Gehrig's disease, is a devastatingly cruel neurodegenerative disorder that robs sufferers of the ability to move, speak and, finally, breathe.

29 Oct 2012

Scientists identify mechanism via Top2b enzyme that drives doxorubicin-induced heart damage

Doxorubicin, a 50-year-old chemotherapy drug still in widespread use against a variety of cancers, has long been known to destroy heart tissue, as well as tumors, in some patients.

29 Oct 2012

Scientists hope to unravel mystery of how Borrelia burgdorferi causes Lyme disease

Investigators at The University of Texas Health Science Center at Houston (UTHealth) have accelerated the search for the bacterial genes that make the Lyme disease bacterium so invasive and persistent. The discovery could advance the diagnosis and treatment of this disease, which affects an estimated 30,000 Americans each year.

29 Oct 2012

Study identifies genetic variations as predictors of prostate cancer-related fatigue

Researchers at Moffitt Cancer Center and the University of South Florida have found that men with prostate cancer who receive androgen deprivation therapy may predictably suffer from fatigue if they have single nucleotide polymorphisms in three pro-inflammatory genes. The discovery highlights the importance of personalized medicine, in which therapies are tailored to a patient's genetic profile.

29 Oct 2012

Study describes how Dbr1 gene halts toxic buildup of TDP-43-a protein

Scientists at the Gladstone Institutes and the Stanford University School of Medicine have discovered how modifying a gene halts the toxic buildup of a protein found in nerve cells. These findings point to a potential new tactic for treating a variety of neurodegenerative conditions, including amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease)-a fatal disease for which there is no cure.

29 Oct 2012

Researchers identify genes that control regeneration of the intestine in planarian flatworms

Researchers report in the journal Developmental Cell that they have identified genes that control growth and regeneration of the intestine in the freshwater planarian Schmidtea mediterranea.

26 Oct 2012

New federal funding enables researchers to unravel how humans develop cancers

A Simon Fraser University scientist working at one of Canada's first epigenomics mapping centres says new federal funding will accelerate researchers' ability to unravel how we develop some of the most common life threatening cancers.

26 Oct 2012

Targeted deletion of major VEGF gene in mice induces vision loss

Millions of people with "wet" macular degeneration are prescribed a class of medication known as anti-VEGF drugs. But now scientists at The Scripps Research Institute (TSRI) have found that a drastic reduction of VEGF activity may do more harm than good.

26 Oct 2012

Zebrafish model can test unique individual genetic differences in humans

The zebrafish is a potential tool for testing one class of unique individual genetic differences found in humans, and may yield information helpful for the emerging field of personalized medicine, according to a team led by Penn State College of Medicine scientists. The differences, or mutations, in question create minor changes in amino acids -- the building blocks of DNA -- from person to person.

26 Oct 2012

NHCS researchers develop human heart cell model of ARVC

Researchers at the National Heart Centre Singapore (NHCS) have successfully created a human heart cell model of arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited heart muscle disorder which puts one at high risk of developing life-threatening arrhythmias and sudden cardiac death.

26 Oct 2012

Study defines complexity of underlying mutations responsible for pancreatic cancers

A large-scale study that defines the complexity of underlying mutations responsible for pancreatic cancers in more than 100 patients was published in Nature today.

26 Oct 2012

Artificial CSP proteins reduce S. pneumoniae competence y more than 90%

The bacterium Streptococcus pneumoniae - which can cause pneumonia, meningitis, bacteremia and sepsis - likes to share its antibiotic-defeating weaponry with its neighbors. Individual cells can pass resistance genes to one another through a process called horizontal gene transfer, or by "transformation," the uptake of DNA from the environment.

26 Oct 2012

HCFC1 protein may cause intellectual disability

Genetics researchers at the University of Adelaide have solved a 40-year mystery for a family beset by a rare intellectual disability - and they've discovered something new about the causes of intellectual disability in the process.

26 Oct 2012

Three new gene variants associated with BMI levels in adults

A large international study has identified three new gene variants associated with body mass index (BMI) levels in adults. The scientific consortium, numbering approximately 200 researchers, performed a meta-analysis of 46 studies, covering gene data from nearly 109,000 adults, spanning four ethnic groups.

26 Oct 2012

Aspirin therapy can extend life of colorectal cancer patients with PIK3CA mutation

Aspirin therapy can extend the life of colorectal cancer patients whose tumors carry a mutation in a key gene, but has no effect on patients who lack the mutation, Dana-Farber Cancer Institute scientists report in the Oct. 25 issue of the New England Journal of Medicine.

25 Oct 2012

Study confirms Elf5 protein as tumor suppressor of breast cancer

A protein that is necessary for lactation in mammals inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis, according to research conducted at the University at Buffalo and Princeton University and highlighted as the cover paper in November issue of Nature Cell Biology.

25 Oct 2012

Advaita receives $125,000 Michigan Emerging Technologies Fund award

Advaita Corporation, a startup company based on technology developed at Wayne State University by Sorin Draghici, Ph.D., professor of computer science in the College of Engineering, received the final installment of a $125,000 award from the Michigan Emerging Technologies Fund program.

25 Oct 2012

Genes News and Research

Maternal bariatric surgery affects cardiovascular risk profile of offsprings

Researchers identify genes linked to serous endometrial cancer

Idea of nuclear reprogramming holds promise for repairing damaged tissue

Researchers use baker's yeast to identify new therapies for Lou Gehrig's disease

Scientists identify mechanism via Top2b enzyme that drives doxorubicin-induced heart damage

Scientists hope to unravel mystery of how Borrelia burgdorferi causes Lyme disease

Study identifies genetic variations as predictors of prostate cancer-related fatigue

Study describes how Dbr1 gene halts toxic buildup of TDP-43-a protein

Researchers identify genes that control regeneration of the intestine in planarian flatworms

New federal funding enables researchers to unravel how humans develop cancers

Targeted deletion of major VEGF gene in mice induces vision loss

Zebrafish model can test unique individual genetic differences in humans

NHCS researchers develop human heart cell model of ARVC

Study defines complexity of underlying mutations responsible for pancreatic cancers

Artificial CSP proteins reduce S. pneumoniae competence y more than 90%

HCFC1 protein may cause intellectual disability

Three new gene variants associated with BMI levels in adults

Aspirin therapy can extend life of colorectal cancer patients with PIK3CA mutation

Study confirms Elf5 protein as tumor suppressor of breast cancer

Advaita receives $125,000 Michigan Emerging Technologies Fund award

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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