Genetic Analysis Techniques News and Research

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Microchip-based device determines the genetic signature of lung tumors

Massachusetts General Hospital (MGH) investigators have shown that an MGH-developed, microchip-based device that detects and analyzes tumor cells in the bloodstream can be used to determine the genetic signature of lung tumors, allowing identification of those appropriate for targeted treatment and monitoring genetic changes that occur during therapy. A pilot study of the device called the CTC-chip will appear in the July 24 New England Journal of Medicine and is receiving early online release.

3 Jul 2008

Genetic variation linked to earlier onset of Alzheimer's symptoms

Investigators at Washington University School of Medicine in St. Louis have identified a genetic variation associated with an earlier age of onset in Alzheimer's disease.

9 Jun 2008

New pathogen from pigs' stomach ulcers

Scientists have isolated a new bacterium in pigs' stomachs thanks to a pioneering technique, offering hope of new treatments to people who suffer with stomach ulcers, according to research published in the June issue of the International Journal of Systematic and Evolutionary Microbiology.

8 Jun 2008

A new search for causes of autism

Dr. Eric Fombonne, from the Research Institute of the MUHC at the Montreal Children's Hospital, is involved in a multi-site consortium to gather DNA samples from 2,000 autism patients and their families over the next three years.

7 May 2008

Whole-organ genomic survey depicts journey from normal to malignant cell

Whole-organ maps that superimpose genetic information over the terrain of cancerous bladders chart the molecular journey from normal cell to invasive cancer, an international research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports online at the journal Laboratory Investigation.

5 May 2008

Rare mutations in salt handling genes protect against hypertension

Howard Hughes Medical Institute (HHMI) researchers have found that rare mutations in three genes contribute to blood pressure variation in the general population.

7 Apr 2008

Study examines association between type of genetic characteristics and cancer

Persons with a certain type of homozygosity (having two identical copies of the same gene, one inherited from each parent), may have a greater predisposition to cancer, according to a study in the March 26 issue of JAMA.

26 Mar 2008

New genetic clue to Parkinson's disease

Researchers at Rhode Island Hospital and The Warren Alpert Medical School of Brown University have discovered a gene that could hold the key to developing new treatments for Parkinson's disease – a progressive and often debilitating movement disorder that affects as many as one million Americans.

24 Mar 2008

Toxic organophosphates appear to contribute to motor neuron disease

Motor neuron disease is a rare, devastating illness in which nerve cells that carry brain signals to muscles gradually deteriorate.

24 Mar 2008

Parasitic worm Schistosoma mekongi more widespread than previously thought

A new genetic analysis, published March 19th in the open-access journal PLoS Neglected Tropical Diseases, suggests that the parasitic worm Schistosoma mekongi is more widespread than previously thought.

20 Mar 2008

Disruption of the Contactin 4 gene on chromosome 3 may be linked to autism spectrum disorder

Eli Hatchwell, M.D., Ph.D., Associate Professor of Pathology at Stony Brook University Medical Center, and colleagues have found that a disruption of the Contactin 4 gene on chromosome 3 may be linked to autism spectrum disorder (ASD).

20 Mar 2008

Scientists unlock secrets of E coli contamination

Using new genetic techniques, scientists are unlocking the secrets of how E coli bacteria contaminate food and make people sick.

11 Mar 2008

New gene discovered that determines hair texture and density in humans

A Columbia University Medical Center research team has discovered a new gene involved in determining hair texture in humans.

26 Feb 2008

Gene chip technology used to distinguish ventilator-associated pneumonia from underlying critical illness

Critically ill patients who need a ventilator to breathe face a high risk of pneumonia.

14 Feb 2008

Genetic difference predicts antidepressant response

Researchers have identified subtle genetic variations that predict the efficacy of two widely used antidepressant drugs.

24 Jan 2008

Genome scan shows Polynesians and Micronesians have almost no genetic relation to Melanesians

The origins and current genetic relationships of Pacific Islanders have generated interest and controversy for many decades.

21 Jan 2008

Columbus brought syphilis to Europe

Did Columbus and his men introduce the syphilis pathogen into Renaissance Europe after contracting it during their voyage to the New World?

15 Jan 2008

Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity

Schizophrenia is a developmental disorder with a large genetic component contributing to increased risk.

9 Jan 2008

Gene variation increases risk of liver tumor in patients with cirrhosis

A particular gene variation appears to significantly increase the risk that individuals with cirrhosis of the liver will go on to develop hepatocellular carcinoma (HCC), a liver tumor that is the third leading cause of cancer death.

2 Jan 2008

Most carriers of Fanconi anemia genes are not at a higher risk of cancer

For almost 50 years, Fanconi anemia has been associated with leukemia. Not just among those who have the genetic disorder but among their family members, whose genes, they were told, made them highly susceptible to a variety of malignancies.

13 Dec 2007