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PAC1R mutation in children with autism may be linked to severity of social problems

A mutation of the gene PAC1R may be linked to the severity of social deficits experienced by kids with autism spectrum disorder, finds a study from a multi-institutional research team led by Children's faculty.

8 Jan 2019

Single tau molecule holds clues to help diagnose neurodegeneration in its earliest stages

Scientists who recently identified the molecular start of Alzheimer's disease have used that finding to determine that it should be possible to forecast which type of dementia will develop over time - a form of personalized medicine for neurodegenerative diseases.

11 Dec 2018

Discovery would help specify role of genetics in the development of neuropsychiatric disorders

Neurobiologists from I.M. Sechenov First Moscow State Medical University confirmed that stress in early age affects the mice with activated and deactivated CDH13 gene in different ways.

27 Nov 2018

2PG Company receives grant to develop sensitive, low-cost molecular diagnostic tests for tuberculosis

Two Pore Guys, Inc. today announced that the company has received a $2.8 million grant from the Bill & Melinda Gates Foundation to develop sensitive, low-cost molecular diagnostic tests for tuberculosis using its solid-state nanopore technology.

19 Nov 2018

Common bacteria that cause foodborne diseases found to be resistant to antibiotics

Brazil's Ministry of Health received reports of 11,524 outbreaks of foodborne diseases between 2000 and 2015, with 219,909 individuals falling sick and 167 dying from the diseases in question.

9 Nov 2018

Vertex gets European CHMP positive opinion for KALYDECO to treat patients with cystic fibrosis

Vertex Pharmaceuticals (Europe) Limited today announces that the European Medicines Agency's Committee for Medicinal Products for Human Use adopted a positive opinion for KALYDECO (ivacaftor) to include the treatment of people with cystic fibrosis (CF) aged 12 to <24 months who have at least one of the following nine mutations in their cystic fibrosis transmembrane conductance regulator gene: G551D, G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549N or S549R.

22 Oct 2018

Co-Diagnostics awarded patent related to its CoPrimer platform technology

Co-Diagnostics, Inc., a molecular diagnostics company with a unique, proprietary platform for the development of molecular diagnostic tests, announced today that it has been awarded a patent from the United States Patent and Trademark Office related to the Company's CoPrimer™ platform technology.

10 Oct 2018

New AUC published for lumbar puncture and spinal fluid analysis in Alzheimer's diagnosis

In preparation for more tools that detect and measure the biology associated with Alzheimer's and other dementias earlier and with more accuracy, an Alzheimer's Association-led Workgroup has published appropriate use criteria for lumbar puncture (spinal tap) and spinal fluid analysis in the diagnosis of Alzheimer's disease.

10 Oct 2018

New DNA test can predict adult heart attack risk much earlier in life

People at high risk of a heart attack in adulthood could be spotted much earlier in life with a one-off DNA test, according to new research part-funded by the British Heart Foundation and published today in the Journal of the American College of Cardiology.

9 Oct 2018

BHCGC consortium to play key role in NIH's large-scale effort to advance precision medicine

The Baylor College of Medicine Human Genome Sequencing Center today announced participation in the National Institutes of Health All of Us Research Program, a large-scale effort to advance precision medicine.

27 Sep 2018

NIH-funded genome centers to speed up breakthroughs in precision medicine

The All of Us Research Program awarded funds totaling $28.6 million to establish three genome centers around the country. These centers will begin to generate genomic data from biosamples contributed by the program's participants.

26 Sep 2018

Cytox, AIBL announce expanded agreement to assess genetic risk for Alzheimer’s

Cytox, a precision medicine company which today is commercializing polygenic risk scoring approaches for assessing genetic risk for developing Alzheimer's disease and other neurological diseases, has announced it has expanded its research collaboration with the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing to test new algorithms for identifying the pre-symptomatic and mild cognitively impaired people most at risk to progress to AD.

24 Sep 2018

LineaRx signs agreement with Takis/Evvivax to develop linear-DNA based anti-cancer vaccines

Applied DNA Sciences Inc. announced today that LineaRx, Inc., its wholly-owned subsidiary focused on next-generation biotherapeutics, has signed a Joint Development Agreement with Takis S.R.L. and Evvivax S.R.L., biotechnology companies focused on the discovery and development of DNA based anti-cancer vaccines for the human and animal markets, respectively.

20 Sep 2018

Researchers develop novel way for dating 'hibernating' HIV strains

Researchers at the BC Centre for Excellence in HIV/AIDS and Simon Fraser University, in partnership with University of British Columbia and Western University, have developed a novel way for dating "hibernating" HIV strains, in an advancement for HIV cure research in the province.

6 Sep 2018

New model could predict personalized waiting time for progression in colorectal cancer

An evolutionary model utilizing serial blood samples from patients with advanced colorectal cancer treated with anti-EGFR therapies in a phase II trial could predict personalized waiting time for progression.

30 Aug 2018

Stress gene increases vulnerability to developing chronic pain, study reveals

A study of more than 1,000 motor vehicle accident survivors published in JNeurosci reveals a common variant in a gene involved in the stress response that increases vulnerability to developing chronic pain. Addressing the interaction between this genetic variant and post-traumatic stress may represent a supplemental or alternative to treatment with addictive opioids.

28 Aug 2018

NRGene constructs comprehensive soy genome diversity-haplotype database

NRGene, the leading genomic big data company, has constructed a comprehensive soy genome diversity-haplotype database based on results from GenoMAGIC™, allowing commercial and academic researchers never-before-available insights into the genomic diversity within the soybean crop.

28 Aug 2018

FDA expands approval of Vertex' cystic fibrosis medicine to treat children aged 12 to <24 months

Vertex Pharmaceuticals Incorporated today announced the U.S. Food and Drug Administration approved KALYDECO® (ivacaftor) to include use in children with cystic fibrosis ages 12 to <24 months who have at least one mutation in their cystic fibrosis transmembrane conductance regulator gene that is responsive to KALYDECO based on clinical and/or in vitro assay data.

16 Aug 2018

CRISPR/Cas9 gene editing can cause greater genetic damage than previously thought

Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create safety implications for gene therapies using CRISPR/Cas9 in the future as the unexpected damage could lead to dangerous changes in some cells.

16 Jul 2018

New findings refine link between clonal hematopoiesis and blood cancer risk

It's a common occurrence in elderly people: Blood cells carrying mutated DNA explosively increase in number, resulting in genetic "mosaicism": the presence of a population of cells that carries an altered genome.

12 Jul 2018