Gerontology News and Research

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Gerontology is the study of the social, psychological and biological aspects of aging.

MR study finds no causal link between age at menarche or age at menopause and Alzheimer's risk

Aging-US published "The role of age at menarche and age at menopause in Alzheimer's disease: evidence from a bidirectional mendelian randomization study" which reported that the association between endogenous estrogen exposure and Alzheimer's disease remains inconclusive in previous observational studies, and few Mendelian randomization studies have focused on their causality thus far.

5 Oct 2021

Immigration adds 1.4 to 1.5 years to U.S. life expectancy, study says

If immigrants to the United States formed their own country, their pre-COVID-19 life expectancies would exceed or match those of the world's leaders in longevity -; Swiss men and Japanese women.

30 Sep 2021

Females more likely to report depressive symptoms than males in late life

Depression affects up to one in four people but is often associated with young adults in the public consciousness.

28 Sep 2021

MIND diet may benefit older adults, research shows

Aging takes a toll on the body and on the mind. For example, the tissue of aging human brains sometimes develops abnormal clumps of proteins that are the hallmark of Alzheimer's disease.

22 Sep 2021

New tools for improving the quality of aged care in Australia

Respect, support and opportunities for feedback are vital to ensure Australians experience quality aged care, say Flinders University experts.

15 Sep 2021

Green tea extract and cocoa-supplemented diets improve survival rate of aging mice

Aging-US published "Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system" which reported that green tea extract (GTE) and cocoa-supplemented diets significantly improved the survival rate of mice.

1 Sep 2021

Abdominal fat and weak muscles associated with loss of gait speed in older people

Weak muscles and abdominal fat are a dangerous combination for older people who have difficulty walking.

31 Aug 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Study highlights the robustness of miRNA modulation during aging process

Aging-US published "miRNAs generated from Meg3-Mirg locus are downregulated during aging" which reported that Aging determines a multilevel functional decline and increases the risk for cardiovascular pathologies.

28 Aug 2021

Cognitive function of older adults could be improved through multidomain lifestyle interventions

Aging-US published "Facility-based and home-based multidomain interventions including cognitive training, exercise, diet, vascular risk management, and motivation for older adults: a randomized controlled feasibility trial" which reported that in an outcome assessor-blinded, randomized controlled trial, participants without dementia and with one or more modifiable dementia risk factors, aged 60-79 years, were randomly assigned to the facility-based MI, the home-based MI, or the control group receiving general health advice.

28 Aug 2021

Fine particle pollution doubles the risk of Alzheimer's disease in Black women

Fine particle pollution may be one reason why Black women have double the risk of developing Alzheimer's than white women, suggests new research from the Keck School of Medicine of USC.

27 Aug 2021

Motor control in older adults may be exacerbated by age-related executive functioning decline

Aging-US published "Cognition and action: a latent variable approach to study contributions of executive functions to motor control in older adults" which reported that Aging is associated with profound alterations in motor control that may be exacerbated by age-related executive functioning decline.

26 Aug 2021

Wake Forest and AFAR receive up to $5 million NIA renewal award to continue management of RCCN

Wake Forest School of Medicine and the American Federation for Aging Research have received a renewal award for up to $5 million over five years from the National Institute on Aging, National Institutes of Health, to continue their management of the Research Centers Collaborative Network.

25 Aug 2021

Study shows higher risk of sarcopenia among older adults who are underweight and lack exercise

Analysis of medical data from around 1800 65-year-old residents of Kobe, a large Japanese city, has shown that at least 3% have possible sarcopenia (*1), revealing that the risks are higher in those who are underweight and don't exercise enough.

24 Aug 2021

Study identifies a novel potential biomarker for hepatocellular carcinoma

Aging-US published "Comprehensive analysis of the competing endogenous circRNA-lncRNA-miRNA-mRNA network and identification of a novel potential biomarker for hepatocellular carcinoma" which reported that there is still a lack of comprehensive analysis of the circular RNA -long non-coding RNA -miRNA-mRNA ceRNA network in hepatocellular carcinoma.

23 Aug 2021

Study investigates the effects of calycosin on breast cancer cell progression

Aging-US published "Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-β1" which reported that in this study, the authors investigated the effects of calycosin on breast cancer cell progression and their underlying mechanisms. Calycosin dose- and time-dependently inhibited proliferation, migration, and invasion by T47D and MCF-7 breast cancer cells by downregulating basic leucine zipper ATF-like transcription factor expression.

23 Aug 2021

Researchers identify genes associated with biochemical recurrence in prostate adenocarcinoma

Aging-US published "Identification of microenvironment related potential biomarkers of biochemical recurrence at 3 years after prostatectomy in prostate adenocarcinoma" which reported that the authors aimed to identify the potential prognostic genes in the prostate adenocarcinoma microenvironment and to estimate the causal effects simultaneously.

20 Aug 2021

Study: PirB inhibits the self-renewal and differentiation capacities of neural stem cells

Aging-US published "PirB functions as an intrinsic suppressor in hippocampal neural stem cells" which reported that neural stem cells play pivotal roles during prenatal development and throughout life.

20 Aug 2021

HMGA1 plays role in gastric cancer cell proliferation and metastasis

Aging-US published "HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression" which reported that HMGA1 is overexpressed in GC cells and the high expression of HMGA1 was correlated with worse survival in GC patients using a bioinformatics assay.

19 Aug 2021

More than 1 in 10 older adults in New York state at risk of elder abuse

More than 1 in 10 older adults in New York state may become victims of elder mistreatment over the next decade, according to a new study from Cornell University and the University of Toronto.

17 Aug 2021