Ghrelin News and Research

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Ghrelin is a hormone produced mainly by P/D1 cells lining the fundus of the human stomach and epsilon cells of the pancreas that stimulates appetite. Ghrelin levels increase before meals and decrease after meals. It is considered the counterpart of the hormone leptin, produced by adipose tissue, which induces satiation when present at higher levels. Ghrelin is also produced in the hypothalamic arcuate nucleus where it stimulates the secretion of growth hormone from the anterior pituitary gland.

Experts to review latest research on bariatric surgery at International summit

On March 28, leading experts across multiple disciplines will convene at the 2nd World Congress on Interventional Therapies for Type 2 Diabetes to review the latest research on bariatric surgery as a treatment option.

17 Mar 2011

Norgine, Tranzyme commence dosing in ulimorelin Phase 3 study for restoring GI function after surgery

Tranzyme Pharma and Norgine B.V., have initiated dosing of ulimorelin in the first of two, Phase 3 pivotal studies - ULISES. Ulimorelin is Tranzyme's intravenous promotility agent in development for the management of postoperative ileus in hospital and acute care settings.

23 Feb 2011

Lack of sleep increases stroke & heart disease risk: Study

New research shows that lack of sleep apparently can increase the risk for stroke and heart attack. British researchers for this study, analyzed data collected from more than 470,000 people in eight countries, including the United States. The study was published Feb. 8 in the European Heart Journal.

13 Feb 2011

Appetite hormones influence 'yo-yo' effect of slimming diets

If you want to lose the kilos you've put on over Christmas, you may be interested in knowing that the hormones related to appetite play an important role in your likelihood of regaining weight after dieting. A new study confirms that people with the highest levels of leptin and lowest levels of ghrelin are more likely to put the centimetres they lost back on again.

13 Jan 2011

Aeterna Zentaris reaches agreement with FDA for Solorel SPA as a diagnostic test in AGHD

Aeterna Zentaris Inc. today announced that it has reached agreement with the Food and Drug Administration (FDA) on a Special Protocol Assessment (SPA) for Solorel® (AEZS-130, macimorelin) which will enable the Company to complete the ongoing registration study required to gain approval as a diagnostic test for Adult Growth Hormone Deficiency (AGHD).

20 Dec 2010

Accelerator announces Series A Preferred Stock financing of Acylin

Accelerator Corporation, a privately held, venture capital backed biotechnology investment and development company, announced today the Series A Preferred Stock financing of Acylin Therapeutics, Inc. This is the eleventh company backed by Accelerator and its first investment in intellectual property developed by either Johns Hopkins University School of Medicine or The Wistar Institute, the co-owners of the underlying technology.

1 Dec 2010

Food, drugs of abuse engage same brain systems, show studies

New animal research helps explain why some eat without hunger or to excess. The studies explore the biological effects of poor eating habits, showing that high-fat diets cause lasting brain changes that may impair healthy eating. Additional studies show that food and drugs of abuse engage many of the same brain systems. The findings were presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news on brain science and health.

16 Nov 2010

Study: Gastric function and autonomic nervous system are impaired in obese individuals

Research on obesity examining the role of hormones and the autonomic functions of the digestive system was presented at the 75th Annual Scientific Meeting of the American CoIlege of Gastroenterology.

19 Oct 2010

Obese have impaired autonomic function which may lead to overeating

Research on obesity examining the role of hormones and the autonomic functions of the digestive system was presented at the 75th Annual Scientific Meeting of the American CoIlege of Gastroenterology.

18 Oct 2010

Preliminary Phase 2 data of TZP-102 for diabetic gastroparesis to be presented at ACG annual meeting

Tranzyme Pharma announced today that John Wo, MD, Professor of Medicine and Director, Clinical Research, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville, Louisville, KY, will present preliminary TZP-102 Phase 2 data at this year's ACG annual meeting. The event is being held at the Henry B. Gonzalez Convention Center in San Antonio TX, October 15-20, 2010. Professor Wo is scheduled to speak on Wednesday, October 20th at 8:50am in Ballroom C1.

18 Oct 2010

Aeterna Zentaris' AEZS-130 demonstrates potential as oral diagnostic test for AGHD

Aeterna Zentaris Inc., today announced that an interim review of a Phase 3 trial of AEZS-130 (macimorelin, SolorelTM), demonstrates the compound may provide a simple, well-tolerated and safe oral diagnostic test for Adult Growth Hormone Deficiency (AGHD). The data was presented earlier today by Beverly M.K. Biller, M.D. of the Harvard Medical School/Massachusetts General Hospital in Boston, at the 5th International Congress of the Growth Hormone Research Society (GRS) and the Insulin-like Growth Factors (IGF) Society in New York City.

6 Oct 2010

Weight loss success linked to amount of sleep: Study

A new study released Tuesday in the Annals of Internal Medicine suggests that sleeping may help one to lose fat. The study compared two groups of people who were trying to lose weight. One group was assigned to sleep 5.5 hours each night for two weeks, while the other was able to sleep 8.5 hours. The scientists found that the sleep deprived people had higher levels of ghrelin. It may be this hormone that drives appetite that leads to excess eating, believe researchers.

6 Oct 2010

Inadequate sleep reduces benefits of dieting

Cutting back on sleep reduces the benefits of dieting, according to a study published October 5, 2010, in the Annals of Internal Medicine.

5 Oct 2010

NIH announces T-R01 project award to examine human microbiome

The National Institutes of Health (NIH) announced today that Martin J. Blaser, MD, the Frederick H. King Professor of Internal Medicine at NYU Langone Medical Center has been awarded one of only twenty NIH Director's Transformative Research Projects (T-R01) award for research entitled "Disappearing Gastrointestinal Microbiota in Epidemic Obesity.

4 Oct 2010

Scientists discover simple molecular test to block GOAT enzyme

Scientists at The Scripps Research Institute have designed a new molecular test that will allow researchers to look for potential drugs targeting a human metabolic enzyme believed to stimulate the appetite and play a role in diabetes.

17 Sep 2010

Study results may point way to effective weight loss maintenance

Many people have experienced the frustration that comes with regaining weight that was lost from dieting. According to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM), the levels of appetite hormones in the body prior to dieting may serve as a predictor of weight regain after dieting.

9 Sep 2010

Lack of sleep likely to develop diabetes, heart disease: Research

People who sleep less than six hours a night may be three times more likely to develop a condition which leads to diabetes and heart disease, according to researchers at the University of Warwick.

8 Sep 2010

Short sleep duration associated with elevated risk of diabetes, heart disease and stroke

People who sleep less than six hours a night may be three times more likely to develop a condition which leads to diabetes and heart disease, according to researchers at the University of Warwick.

7 Sep 2010

Achievement of sufficient night sleep needed in obesity prevention and weight-management programs

A study in the Sept. 1 issue of the journal Sleep shows that teens who slept less than eight hours per weeknight ate higher proportions of fatty foods and snacks than adolescents who slept eight hours or more. The results suggest that short sleep duration may increase obesity risk by causing small changes in eating patterns that cumulatively alter energy balance, especially in girls.

2 Sep 2010

Ipsen 2010 first half revenue increases to €31.7 million

The Board of Directors of Ipsen, chaired by Jean-Luc Bélingard, met on August 30, 2010 to review the Group's results for the first half 2010, published today

31 Aug 2010