Heart Defect News and Research

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NHLBI grant for identifying genetic and epigenetic causes of human congenital heart disease

Researchers at Children's Hospital Boston and Brigham and Women's Hospital have received funding from the National Heart, Lung, and Blood Institute (NHLBI) to support their search for undiscovered gene defects that cause congenital heart disease. The $4.19 million, 6-year grant is part of the Pediatric Cardiac Genomics Consortium (PCGC), which seeks to identify genetic and epigenetic causes of human congenital heart disease, and relate genetic variants present in the congenital heart disease patient population to clinical outcomes.

23 Dec 2009

Landmark study provides new insight into congenital heart defects

Researchers from the UC San Diego, School of Medicine and colleagues have identified a new gene, ETS-1, that is linked to human congenital heart defects. The landmark study, recently published online in the journal of Human Molecular Genetics, provides important insights into some of the most prevalent forms of congenital heart defects in humans, including ventricular septal defects and potentially hypoplastic left heart syndrome, a uniformly fatal heart abnormality.

18 Dec 2009

Embryonic signalling pathways suggest a new therapeutic approach to recover from heart attack

Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research, scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, are the first to prove that this signalling pathway targets heart muscle cells and thus reveal its crucial role in heart development and repair

10 Dec 2009

Medical negligence: $22.3M for loss of left leg

A Cook County jury late yesterday awarded the parents of a now ten-year-old boy with a $22.3 million verdict in a medical negligence case arising out of the care and treatment on May 29, 1999 at Advocate Christ Medical Center/Hope Children's Hospital, in the Chicago suburb of Oak Lawn, which resulted in the loss of the boy's left leg.

25 Nov 2009

New computational tool may aid surgeons plan for life-saving pediatric operation

A team of researchers at the University of California, San Diego and Stanford University has developed a way to simulate blood flow on the computer to optimize surgical designs. It is the basis of a new tool that may help surgeons plan for a life-saving operation called the "Fontan" surgery, which is performed on babies born with severe congenital heart defects.

24 Nov 2009

Human-derived UCB stem cell transplant has positive therapeutic effects on specific lung and heart disorders

Two separate studies published in the current issue of Cell Transplantation (18:8), - now freely available on-line at http://www.ingentaconnect.com/content/cog/ct - have shown that transplanted human-derived umbilical cord blood (UCB) stem cells transplanted in an animal model had positive therapeutic effects on specific lung and heart disorders the animal models.

24 Nov 2009

NHLBI-supported research shares new strategies on hypertension, heart defect and air pollution

New education strategies for better controlling hypertension and research suggesting a possible link between short-term and long-term exposure to air pollution and increased risk of constricted blood vessels are among the research highlights from studies supported by the National Heart, Lung, and Blood Institute (NHLBI) at the American Heart Association's 2009 Scientific Sessions in Orlando held Nov. 14-18.

20 Nov 2009

Sildenafil drug improves cardiac performance in young adults with congenital heart disease

Heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia.

19 Nov 2009

Developmental biologists to participate in $100 million federal 'Bench to Bassinet' network

Developmental biologists at the University of Pittsburgh have been chosen to participate in a $100 million federal "Bench to Bassinet" network that is dedicated to learning about the formation of the cardiovascular system and applying that knowledge to create new diagnostic and intervention strategies for congenital heart disease.

18 Nov 2009

Sildenafil improves heart function in youngsters with single ventricle congenital heart disease

Heart function significantly improved in children and young adults with single ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia.

18 Nov 2009

New shunt procedure may save infants with underdeveloped heart

Infants born with a severely underdeveloped heart are more likely to survive to their first birthday when treated with a new shunt procedure - yet it may not be the safest surgery long term, according to research presented at the American Heart Association's Scientific Sessions 2009.

16 Nov 2009

Just one test not enough to detect heart defects in young athletes

To best detect early signs of life-threatening heart defects in young athletes, screening programs should include both popular diagnostic tests, not just one of them, according to new research from heart experts at Johns Hopkins.

16 Nov 2009

Academic Health Center receives 128 grants totaling nearly $35 million in federal stimulus money

Academic Health Center scientists, physicians, and research centers have attracted 128 grants totaling nearly $35 million in federal stimulus money (as of Nov. 10) since the American Recovery and Reinvestment Act was approved in February 2009. This will result in a total economic impact of more than $105 million; according to the National Institutes of Health, $1 of research funding multiplies to more than $2 of goods and services in the economy.

11 Nov 2009

AET completes real-time remote diagnosis of a newborn baby's heart murmur

Telemedicine solution provider AET (American Educational Telecommunications; www.aetmedical.com) completed a first of its kind, real-time remote diagnosis of a newborn baby's heart murmur between Faith Regional Health Services and Children's Hospital & Medical Center in Norfolk and Omaha, NE, respectively.

3 Nov 2009

National Heart, Lung and Blood Institutes funds multi-year project

Scientists at the Gladstone Institute of Cardiovascular Disease (GICD) will receive $10 million over the next 6 years to find the genetic causes of congenital heart disease.

28 Oct 2009

Transcatheter valve may eliminate repeat surgeries in children with heart defects; multicenter study shows good outcomes

Children born with certain heart defects have impaired blood flow from the right ventricle to the pulmonary artery leading to the lungs, requiring implanted devices (known as right-ventricular outflow tract conduits) to maintain the flow. However, these conduits fail over time, and children typically face multiple open-heart operations during their lives to reopen the passage.

27 Oct 2009

MUSC launches Social Media Newsroom for real-time information on medical news and research

As the editorial landscape continues to evolve with the emergence of social media, many people struggle to find trusted resources that offer accurate, real time information related to healthcare news and research.

21 Oct 2009

OptumHealth’s conference to focus on advancements in fetal diagnosis and treatment

OptumHealth Inc. has teamed with The Children’s Hospital of Philadelphia (CHOP) to present a two-day educational conference focused on clinical advancements in fetal diagnosis and treatment, neonatal care and pediatric care. The gathering runs through today, and is part of OptumHealth’s Network Spotlight Conferences program.

12 Oct 2009

CryoValve SG aortic human heart valve receives Humanitarian Use Device designation

CryoLife, Inc., an implantable biological medical device and cardiovascular tissue processing company, today announced that it has received a Humanitarian Use Device (HUD) designation from the Food and Drug Administration (FDA) for its CryoValve® SG aortic human heart valve.

6 Oct 2009

Latest optical and laser technology in medicine displayed at FiO meeting

From scopes that help premature babies breathe to techniques for imaging live neurons and beating hearts as they develop, the latest optical and laser technology being deployed in medicine and the biosciences will be on display at the Optical Society's (OSA) Annual Meeting, Frontiers in Optics (FiO), which takes place Oct. 11-15 at the Fairmont San Jose Hotel and the Sainte Claire Hotel in San Jose, Calif.

1 Oct 2009