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New understanding of the critical molecular factors that permit viruses to jump from one species to another

Researchers studying strains of a lethal canine virus and a related human virus have determined why the canine virus was able to spread so quickly from cats to dogs, and then from sick dogs to healthy dogs.

19 Mar 2006

Oddly shaped DNA can cause DNA breaks in mammalian cells

When otherwise normal DNA adopts an unusual shape called Z-DNA, it can lead to the kind of genetic instability associated with cancers such as leukemia and lymphoma, according to a study by researchers at The University of Texas M. D. Anderson Cancer Center.

21 Feb 2006

Inactivating Rad9 protien could make cancer cells easier to kill with ionizing radiation

The researchers found that Rad9, previously considered a "watchman" that checks for DNA damage, is actually a "repairman" that fixes dangerous breaks in the DNA double helix. They found Rad9 is especially active in telomeres, the protective ends of chromosomes.

17 Feb 2006

Groundbreaking research into some of the most deadly antibiotic-resistant diseases

Pioneering research by a North East of England scientist could lead to a cure for some of the most deadly antibiotic-resistant diseases.

15 Dec 2005

Researchers learn to detect DNA mutations

A team of ASU researchers led by Nongjian Tao and Peiming Zhang has developed a new, breakthrough technique for the detection of DNA mutations.

13 Dec 2005

Search for genes responsible for anxiety disorders

Increasing the activity of two enzymes better known for their role in oxidative stress metabolism turns normally relaxed mice into "Nervous Nellies," according to research conducted at the Salk Institute for Biological Studies and reported in the early online edition of Nature.

30 Oct 2005

New insights into how genetic mutations arise

Researchers at Stanford University have created a larger-than-normal DNA molecule that is copied almost as efficiently as natural DNA.

27 Oct 2005

Bouncing helicases possibly play a preventative role in keeping the genome intact

Researchers studying how proteins called helicases travel along strands of DNA have found that when the proteins hit an obstacle they snap back to where they began, repeating the process over and over, possibly playing a preventative role in keeping the genome intact.

27 Oct 2005

DOS47 scientific paper published in the Journal of Experimental Therapeutics and Oncology

Helix BioPharma announced today the publication of a scientific paper in the Journal of Experimental Therapeutics and Oncology (volume 5, number 2, pp. 93-99), entitled "Urease-induced alkalinization of extracellular pH and its antitumour activity in human breast and lung cancers."

25 Oct 2005

Possible molecular origin of at least nine human diseases of nervous system degeneration

These neurodegenerative diseases, including Huntington's disease, share an abnormal deposit of proteins inside nerve cells. This deposition of protein results from a kind of genetic stutter within the cell's nucleus asking for multiple copies of the amino acid glutamine, a building block of protein structure.

26 Sep 2005

Helix receives approval to conduct a clinical trial of Topical Interferon Alpha-2b in Sweden

Helix BioPharma today announced that it has received approval from Sweden's drug regulatory authority, the Medical Products Agency (MPA), to conduct a Phase II clinical trial of Topical Interferon Alpha-2b in patients with ano-genital warts (condylomata acuminata), who are positive for infection with the human papilloma virus (HPV).

12 Sep 2005

Simple new way to modify collagen, paving the way for better infection-fighting bandages

Collagen often pops up in beauty products and supermodel lips. But by mating collagen with a molecular hitchhiker, materials scientists at Johns Hopkins hope to create some important medical advances.

30 Aug 2005

New tool to help unravel the function of an elusive DNA structure

A Rensselaer researcher has developed a new tool to help unravel the function of an elusive DNA structure. The findings, which were presented today at the 230th national meeting of the American Chemical Society (ACS) in Washington, D.C., could lead to a better understanding of diseases such as cancer and diabetes.

29 Aug 2005

New insight into how sunlight affects DNA

Chemists at Ohio State University have gained new insight into how sunlight affects DNA. And what they found overturns ideas about genetic mutation that originated decades ago.

24 Aug 2005

First proof of how the rare disorder Fanconi anemia causes chromosomal instability

The scientists found a gene mutation not previously known to be related to Fanconi anemia, and they say that BRIP1 is the first gene associated with the disease whose protein has a known function.

22 Aug 2005

Unique arrays of proteins tethered onto self-assembled DNA nanostructures

In the fifty-year history since the structure of DNA was first revealed, what was once a Nobel prize- winning research discovery has become an omnipresent cultural icon co-opted for promoting everything from fragrances to musical acts.

20 Jun 2005

Helix opens additional sites for its Topical Interferon Alpha-2b Phase II clinical study

Helix BioPharma announced today the opening of two additional German sites for the Phase II clinical trial of its Topical Interferon Alpha-2b product at the Charité Berlin, one of the largest university hospitals in Europe.

2 Jun 2005

Researchers unravel how nature releases the torque built up in DNA at the molecular level

A Dutch led international team of researchers has unravelled how nature releases the torque built up in DNA at the molecular level. The researchers from Delft University of Technology, the Ecole Normale Supérieure in Paris and the Sloan-Kettering Institute in New York published their findings in the 31 March 2005 issue of Nature. An artistic impression of the enzyme at work is featured on the cover of this issue.

4 May 2005

Researchers make new advances in determining the structure of all possible DNA sequences

Oregon State University researchers have made significant new advances in determining the structure of all possible DNA sequences – a discovery that in one sense takes up where Watson and Crick left off, after outlining in 1953 the double-helical structure of this biological blueprint for life.

3 May 2005

An exceptionally effective lead-detection protein

Scientists from the U.S. Department of Energy’s Brookhaven National Laboratory and the University of Chicago have discovered that a member of a well-known protein family is better at detecting lead than any other known substance.

5 Apr 2005